Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies von Vergne, Fabrice, Bernardelli, Patrick, Lorthiois, Edwige, Pham, Nga, Proust, Emmanuelle, Oliveira, Chrystelle, Mafroud, Abdel-Kader, Royer, Frederique, Wrigglesworth, Roger, Schellhaas, Jennifer, Barvian, Mark, Moreau, François, Idrissi, Moulay, Tertre, Anita, Bertin, Bernadette, Coupe, Magali, Berna, Patrick, Soulard, Patricia

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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivati... von Vergne, Fabrice, Bernardelli, Patrick, Lorthiois, Edwige, Pham, Nga, Proust, Emmanuelle, Oliveira, Chrystelle, Mafroud, Abdel-Kader, Ducrot, Pierre, Wrigglesworth, Roger, Berlioz-Seux, Françoise, Coleon, Francis, Chevalier, Eric, Moreau, François, Idrissi, Moulay, Tertre, Anita, Descours, Arnaud, Berna, Patrick, Li, Mei

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The Discovery of Capsazepine, the First Competitive Antagonist of the Sensory Neuron Excitants Capsaicin and Resiniferatoxin von Walpole, Christopher S. J, Bevan, Stuart, Bovermann, Guenter, Boelsterli, Johann J, Breckenridge, Robin, Davies, John W, Hughes, Glyn A, James, Iain, Oberer, Lukas

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Bradyzide, a potent non‐peptide B 2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia von Burgess, Gillian M, Perkins, Martin N, Rang, Humphrey P, Campbell, Elizabeth A, Brown, Michael C, McIntyre, Peter, Urban, Laszlo, Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Wrigglesworth, Roger, Lee, Wai, Davis, Clare, Phagoo, Steve B, Davis, Andrew J, Phillips, Elsa, Drake, Gillian S, Hughes, Glyn A, Dunstan, Andrew, Bloomfield, Graham C

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Novel series of 8H-quinazolino[4,3-b]quinazolin-8-ones via two Niementowski condensations von Alexandre, François-René, Berecibar, Amaya, Wrigglesworth, Roger, Besson, Thierry

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Thiophene and bioisostere derivatives as new MMP12 inhibitors von Badland, Matthew, Compère, Delphine, Courté, Karine, Dublanchet, Anne-Claude, Blais, Stéphane, Manage, Ajith, Peron, Guillaume, Wrigglesworth, Roger

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Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors von Badland, Matthew, Devillers, Ingrid, Durand, Corinne, Fasquelle, Véronique, Gaudillière, Bernard, Jacobelli, Henry, Manage, Ajith C., Pevet, Isabelle, Puaud, Jocelyne, Shorter, Anthony J., Wrigglesworth, Roger

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Efficient synthesis of thiazoloquinazolinone derivatives von Alexandre, François-René, Berecibar, Amaya, Wrigglesworth, Roger, Besson, Thierry

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Nonpeptide Bradykinin B2 Receptor Antagonists:  Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B2 Receptor Antagonists von Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Davies, John W, Wrigglesworth, Roger, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, McIntyre, Peter, Brown, Michael C, Burgess, Gillian M, Lee, Wai, Davis, Clare, Yaqoob, Mohammed, Phagoo, Steve B, Phillips, Elsa, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J, Rang, Humphrey P

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1-(2-Nitrophenyl)thiosemicarbazides:  A Novel Class of Potent, Orally Active Non-Peptide Antagonist for the Bradykinin B2 Receptor von Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Ko, Soo Y, Wrigglesworth, Roger, Hughes, Glyn A, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, Brown, Michael C, Lee, Wai, Burgess, Gillian M, Davis, Clare, Yaqoob, Mohammed, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J, Rang, Humphrey P

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Novel series of 8 H-quinazolino[4,3- b]quinazolin-8-ones via two Niementowski condensations von Alexandre, François-René, Berecibar, Amaya, Wrigglesworth, Roger, Besson, Thierry

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Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1 von Lorthiois, Edwige, Bernardelli, Patrick, Vergne, Fabrice, Oliveira, Chrystelle, Mafroud, Abdel-Kader, Proust, Emmanuelle, Heuze, Lamia, Moreau, François, Idrissi, Moulay, Tertre, Anita, Bertin, Bernadette, Coupe, Magali, Wrigglesworth, Roger, Descours, Arnaud, Soulard, Patricia, Berna, Patrick

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Synthesis of novel 1,3,4-benzotriazepine derivatives from 4-oxo-3,1-benzoxazine and 3,1-benzothiazine-2-carbonitriles von Alexandre, François-René, Berecibar, Amaya, Wrigglesworth, Roger, Perreux, Laurence, Guillon, Jean, Léger, Jean-Michel, Thiéry, Valérie, Besson, Thierry

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Efficient routes to cyclic 2,3-epoxyalcohols from cycloalkenyl ketones, via cycloalkenyl alcohols von Marson, Charles M., Walker, Andrew J., Pickering, Jane, Harper, Steven, Wrigglesworth, Roger, Edge, Simon J.

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Bradyzide, a potent non‐peptide B2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia von Burgess, Gillian M, Perkins, Martin N, Rang, Humphrey P, Campbell, Elizabeth A, Brown, Michael C, McIntyre, Peter, Urban, Laszlo, Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Wrigglesworth, Roger, Lee, Wai, Davis, Clare, Phagoo, Steve B, Davis, Andrew J, Phillips, Elsa, Drake, Gillian S, Hughes, Glyn A, Dunstan, Andrew, Bloomfield, Graham C

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Synthesis of 2-amino-4h-3,1-benzoxazines from diphenyl cyanocarbonimidate. facile replacement of the n-cyanoimine function by nitrogen nucleophiles von Garratt, Peter J., Hobbs, Christopher J., Wrigglesworth, Roger

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Stereoselective construction of quaternary centers at ambient temperature by the highly stereocontrolled migration of groups containing sp-, sp2-, and sp3-hybridized carbon atoms von Marson, Charles M, Walker, Andrew J, Pickering, Jane, Hobson, Adrian D, Wrigglesworth, Roger, Edge, Simon J

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Synthesis, Structure−Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-h i]indoles:  Discovery of Potent, Selecti... von Burnouf, Catherine, Auclair, Eric, Avenel, Nadine, Bertin, Bernadette, Bigot, Christèle, Calvet, Alain, Chan, Kam, Durand, Corinne, Fasquelle, Veronique, Féru, Frédéric, Gilbertsen, Richard, Jacobelli, Henry, Kebsi, Adel, Lallier, Emmanuelle, Maignel, Jacquie, Martin, Brigitte, Milano, Stéphane, Ouagued, Malika, Pascal, Yves, Pruniaux, Marie-Pierre, Puaud, Jocelyne, Rocher, Marie-Noëlle, Terrasse, Christophe, Wrigglesworth, Roger, Doherty, Annette M

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Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region" von Walpole, Christopher S. J, Wrigglesworth, Roger, Bevan, Stuart, Campbell, Elizabeth A, Dray, Andy, James, Iain F, Perkins, Martin N, Reid, Derek J, Winter, Janet

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Similarities and Differences in the Structure−Activity Relationships of Capsaicin and Resiniferatoxin Analogues von Walpole, Christopher S. J, Bevan, Stuart, Bloomfield, Graham, Breckenridge, Robin, James, Iain F, Ritchie, Timothy, Szallasi, Arpad, Winter, Janet, Wrigglesworth, Roger

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