Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents von Warshakoon, Namal C., Sheville, Justin, Bhatt, Ritu Tiku, Ji, Wei, Mendez-Andino, Jose L., Meyers, Kenneth M., Kim, Nick, Wos, John A., Mitchell, Chrissy, Paris, Jennifer L., Pinney, Beth B., Reizes, Ofer, Hu, X. Eric

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MCH-R1 antagonists: what is keeping most research programs away from the clinic? von Méndez-Andino, José L., Wos, John A.

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Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists von Tian, Xinrong, Mishra, Rajesh K., Switzer, Adrian G., Hu, X. Eric, Kim, Nick, Mazur, Adam W., Ebetino, Frank H., Wos, John A., Crossdoersen, Doreen, Pinney, Beth B., Farmer, Julie A., Sheldon, Russell J.

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Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach von Tian, Xinrong, Field, Timothy B, Switzer, Adrian G, Mazur, Adam W, Ebetino, Frank H, Wos, John A, Berberich, Steve M, Jayasinghe, Lalith R, Obringer, Cindy M, Dowty, Martin E, Pinney, Beth B, Farmer, Julie A, Crossdoersen, Doreen, Sheldon, Russell J

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Design, synthesis, and evaluation of proline based melanocortin receptor ligands von Tian, Xinrong, Field, Timothy, Mazur, Adam W., Ebetino, Frank H., Wos, John A., Crossdoersen, Doreen, Pinney, Beth B., Sheldon, Russell J.

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Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents von Tian, Xinrong, Switzer, Adrian G, Derose, Steve A, Mishra, Rajesh K, Solinsky, Mark G, Mumin, Rashid N, Ebetino, Frank H, Jayasinghe, Lalith R, Webster, Mark E, Colson, Anny-Odile, Crossdoersen, Doreen, Pinney, Beth B, Farmer, Julie A, Dowty, Martin E, Obringer, Cindy M, Cruze, Charles A, Burklow, Melissa L, Suchanek, Paula M, Dong, Lily, Dirr, Mary Kay, Sheldon, Russell J, Wos, John A

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Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG von Meyers, Kenneth M., Kim, Nicholas, Méndez-Andino, José L., Hu, X. Eric, Mumin, Rashid N., Klopfenstein, Sean R., Wos, John A., Mitchell, Maria C., Paris, Jennifer L., Ackley, David C., Holbert, Jerry K., Mittelstadt, Scott W., Reizes, Ofer

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Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors von Wang, Yili, O’Neil, Steven V., Wos, John A., Oppong, Kofi A., Laufersweiler, Michael C., Soper, David L., Ellis, Christopher D., Baize, Mark W., Fancher, Amy N., Lu, Wei, Suchanek, Maureen K., Wang, Richard L., Schwecke, William P., Cruze, Charles A., Buchalova, Maria, Belkin, Marina, De, Biswanath, Demuth, Thomas P.

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Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists von Meyers, Kenneth M., Méndez-Andino, José, Colson, Anny-Odile, Hu, X. Eric, Wos, John A., Mitchell, Maria C., Hodge, Karen, Howard, Jeremy, Paris, Jennifer L., Dowty, Martin E., Obringer, Cindy M., Reizes, Ofer

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Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis von Oppong, Kofi A., Ellis, Christopher D., Laufersweiler, Michael C., O’Neil, Steven V., Wang, Yili, Soper, David L., Baize, Mark W., Wos, John A., De, Biswanath, Bosch, Gregory K., Fancher, Amy N., Lu, Wei, Suchanek, Maureen K., Wang, Richard L., Demuth, Thomas P.

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Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors von O’Neil, Steven V., Wang, Yili, Laufersweiler, Michael C., Oppong, Kofi A., Soper, David L., Wos, John A., Ellis, Christopher D., Baize, Mark W., Bosch, Gregory K., Fancher, Amy N., Lu, Wei, Suchanek, Maureen K., Wang, Richard L., De, Biswanath, Demuth, Thomas P.

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Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors von Ellis, Christopher D., Oppong, Kofi A., Laufersweiler, Michael C., O’Neil, Steven V., Soper, David L., Wang, Yili, Wos, John A., Fancher, Amy N., Lu, Wei, Suchanek, Maureen K., Wang, Richard L., De, Biswanath, Demuth, Thomas P.

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Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists von Tian, Xinrong, Chen, Xuemei, Gan, Lixian, Hayes, Jeffery C., Switzer, Adrian G., Solinsky, Mark G., Ebetino, Frank H., Wos, John A., Pinney, Beth B., Farmer, Julie A., Crossdoersen, Doreen, Sheldon, Russell J.

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Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity von Kim, Nick, Meyers, Kenneth M., Mendez-Andino, Jose L., Warshakoon, Namal C., Ji, Wei, Wos, John A., Colson, Annyodile, Mitchell, M. Chrissy, Davis, Jan R., Pinney, Beth B., Reizes, Ofer, Hu, X. Eric

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The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: A novel class of potent MCH-R1 antagonists von Méndez-Andino, José L., Colson, Anny-Odile, Meyers, Kenneth M., Mitchell, Maria C., Hodge, Karen, Howard, Jeremy M., Kim, Nicholas, Ackley, David C., Holbert, Jerry K., Mittelstadt, Scott W., Dowty, Martin E., Obringer, Cindy M., Suchanek, Paula, Reizes, Ofer, Eric Hu, X., Wos, John A.

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Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists—Increasing selectivity over hERG von Meyers, Kenneth M., Méndez-Andino, José L., Colson, Anny-Odile, Warshakoon, Namal C., Wos, John A., Mitchell, Maria C., Hodge, Karen M., Howard, Jeremy M., Ackley, David C., Holbert, Jerry K., Mittelstadt, Scott W., Dowty, Martin E., Obringer, Cindy M., Reizes, Ofer, Hu, X. Eric

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The Synthesis and Human FP Receptor Binding Affinity of 13, 14-Dihydro Prostaglandin F1α Sulfonamides : Potential Treatments for Osteoporosis von WANG, Yili, SOPER, David L., DIRR, Michelle J., DELONG, Mitchell A., DE, Biswanath, WOS, John A.

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Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors von Soper, David L., Sheville, Justin, O’Neil, Steven V., Wang, Yili, Laufersweiler, Michael C., Oppong, Kofi A., Wos, John A., Ellis, Christopher D., Fancher, Amy N., Lu, Wei, Suchanek, Maureen K., Wang, Richard L., De, Biswanath, Demuth, Thomas P.

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Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme von Laufersweiler, Michael C., Wang, Yili, Soper, David L., Suchanek, Maureen K., Fancher, Amy N., Lu, Wei, Wang, Richard L., Oppong, Kofi A., Ellis, Christopher D., Baize, Mark W., O’Neil, Steven V., Wos, John A., Demuth, Thomas P.

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Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis von Soper, David L, Milbank, Jared B. J, Mieling, Glen E, Dirr, Michelle J, Kende, Andrew S, Cooper, Robin, Jee, Webster S. S, Yao, Wei, Chen, Jian Liang, Bodman, Mark, Lundy, Mark W, De, Biswanath, Stella, Mark E, Ebetino, Frank H, Wang, Yili, deLong, Mitchell A, Wos, John A

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