Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis von Works, Melissa G, Yin, Fangfang, Yin, Catherine C, Yiu, Ying, Shew, Kenneth, Tran, Thanh-Thuy, Dunlap, Nahoko, Lam, Jennifer, Mitchell, Tim, Reader, John, Stein, Paul L, D'Andrea, Annalisa

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Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment von Steggerda, Susanne M, Bennett, Mark K, Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie R, Li, Weiqun, MacKinnon, Andrew L, Makkouk, Amani, Marguier, Gisele, Murray, Peter J, Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna L M, Van de Velde, Lee-Ann, Wang, Tracy, Works, Melissa, Zhang, Jing, Zhang, Winter, Gross, Matthew I

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New candidate biomarkers in the female genital tract to evaluate microbicide toxicity von Fields, Scott, Song, Benben, Rasoul, Bareza, Fong, Julie, Works, Melissa G, Shew, Kenneth, Yiu, Ying, Mirsalis, Jon, D'Andrea, Annalisa

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Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer von Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

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Soluble TNF Receptor 1-Secreting ex Vivo-Derived Dendritic Cells Reduce Injury After Stroke von Works, Melissa G, Koenig, Jenny B, Sapolsky, Robert M

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Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice von Rutten, Kris, Misner, Dinah L., Works, Melissa, Blokland, Arjan, Novak, Thomas J., Santarelli, Luca, Wallace, Tanya L.

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Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat von Manley, Nathan C, Caso, Javier R, Works, Melissa G, Cutler, Andrew B, Zemlyak, Ilona, Sun, Guohua, Munhoz, Carolina D, Chang, Sydney, Sorrells, Shawn F, Ermini, Florian V, Decker, Johannes H, Bertrand, Anthony A, Dinkel, Klaus M, Steinberg, Gary K, Sapolsky, Robert M

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Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways von Lee, I-Ping, Evans, Andrew K, Yang, Cissy, Works, Melissa G, Kumar, Vineet, De Miguel, Zurine, Manley, Nathan C, Sapolsky, Robert M

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Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T cell Function against Multiple Myeloma Is Enhanced in the Presence of Lenalidomide von Works, Melissa, Soni, Neha, Hauskins, Collin, Sierra, Catherine, Baturevych, Alex, Jones, Jon C, Curtis, Wendy, Carlson, Patrick, Johnstone, Timothy G, Kugler, David, Hause, Ronald J, Jiang, Yue, Wimberly, Lindsey, Clouser, Christopher R, Jessup, Heidi K, Sather, Blythe, Salmon, Ruth A, Ports, Michael O

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Orvacabtagene Autoleucel (orva-cel; JCARH125): A Fully Human BCMA-Targeted Second-Generation CAR T Cell Product Characterized By a Predominant Central Memory Phenotype with High in... von Colonna, Lucrezia, Navarro, Garnet, Devries, Todd, Beckett, Valeria, Amsberry, Anthony, Radhakrishnan, Aditya, Piasecki, Julia, Heipel, Mark, Li, Yan, Kavita, Uma, Works, Melissa G, Mujacic, Mirna

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Abstract 2320: Avadomide (CC-122) increases effector function and reverses exhaustion in chronically stimulated lisocabtagene maraleucel anti-CD19 CAR T drug product von Jessup, Heidi K., Thomas, Evan P., Qin, Jim S., Jiang, Yue, Baturevych, Oleksandr, Soni, Neha, Chen, Aye T., Salmon, Ruth A., Works, Melissa G., Ports, Michael O.

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Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum von Li, Jie, Duarte, Terence, Kocabas, Arif, Works, Melissa, McConnell, Susan K., Hynes, Mary A.

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Response to Bcma CAR-T Cells Correlates with Pretreatment Target Antigen Density and Is Improved By Small Molecule Inhibition of Gamma Secretase von Green, Damian J., Pont, Margot, Cowan, Andrew J., Cole, Gabriel O, Sather, Blythe Duke, Nagengast, Anne M, Song, Xaoling, Thomas, Sushma, Wood, Brent L, Blake, Michelle L, Works, Melissa G, Gooley, Ted A, Maloney, David G., Riddell, Stanley R.

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Efficacy and Safety of Fully Human Bcma CAR T Cells in Combination with a Gamma Secretase Inhibitor to Increase Bcma Surface Expression in Patients with Relapsed or Refractory Mult... von Cowan, Andrew J., Pont, Margot, Sather, Blythe Duke, Turtle, Cameron J., Till, Brian G., Nagengast, Anne M, Libby, Edward N., Becker, Pamela S., Coffey, David G., Tuazon, Sherilyn A., Wood, Brent L, Blake, Michelle L, Works, Melissa G, Gooley, Ted A, Wu, Qian Vicky, Maloney, David G., Riddell, Stanley R., Green, Damian J.

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Lenalidomide Enhances Anti-BCMA Chimeric Antigen Receptor T Cell Function Against Multiple Myeloma von Works, Melissa, Soni, Neha, Hauskins, Collin, Sierra, Catherine, Baturevych, Alex, Jones, Jon, Curtis, Wendy, Johnstone, Timothy, Kugler, David, Jiang, Yue, Hause, Ron, Sather, Blythe Duke, Salmon, Ruth, Ports, Michael

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Fully Human Bcma Targeted Chimeric Antigen Receptor T Cells Administered in a Defined Composition Demonstrate Potency at Low Doses in Advanced Stage High Risk Multiple Myeloma von Green, Damian J., Pont, Margot, Sather, Blythe Duke, Cowan, Andrew J., Turtle, Cameron J., Till, Brian G., Nagengast, Anne M, Libby, Edward N., Becker, Pamela S., Coffey, David G., Tuazon, Sherilyn A., Wood, Brent, Blake, Michelle, Works, Melissa, Thompson, Bruce S, Gooley, Ted, Appelbaum, Frederick R., Maloney, David G., Riddell, Stanley R.

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Abstract 1830: Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer von Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Braas, Daniel, Graeber, Thomas G., Works, Melissa, Parlati, Francesco, Demo, Susan, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather, Shackelford, David B.

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Abstract 4711: CB-839, a selective glutaminase inhibitor, synergizes with signal transduction pathway inhibitors to enhance anti-tumor activity von Rodriguez, Mirna, Zhang, Winter, Bennett, Mark, Emberley, Ethan, Gross, Mathew, Janes, Julie, MacKinnon, Andrew, Pan, Alison, Steggerda, Susanne, Works, Melissa, Parlati, Francesco

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Abstract 552: Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response von Works, Melissa, Bennett, Mark, Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie, Li, Weiqun, Mackinnon, Andy, Marguier, Gisele, Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna, Steggerda, Susanne, Wang, Tracy, Zhang, Jing, Zhang, Winter, Gross, Matthew

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Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout ( PDE4B −/−) mice von Rutten, Kris, Wallace, Tanya L., Works, Melissa, Prickaerts, Jos, Blokland, Arjan, Novak, Thomas J., Santarelli, Luca, Misner, Dinah L.

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