Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling von Bayle, Elliott D, Svensson, Fredrik, Atkinson, Benjamin N, Steadman, David, Willis, Nicky J, Woodward, Hannah L, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers von Anderhub, Simon J, Mak, Grace Wing-Yan, Gurden, Mark D, Faisal, Amir, Drosopoulos, Konstantinos, Walsh, Katie, Woodward, Hannah L, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Theofani, Efthymia, Filosto, Simone, Saville, Harry, Burke, Rosemary, van Montfort, Rob L M, Raynaud, Florence I, Blagg, Julian, Hoelder, Swen, Eccles, Suzanne A, Linardopoulos, Spiros

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Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening von Vidler, Lewis R, Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Martin, Sarah, Tomsett, Michael, Woodward, Hannah, Brown, Nathan, Knapp, Stefan, Hoelder, Swen

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Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders von Bellenie, Benjamin R, Cheung, Kwai-Ming J, Varela, Ana, Pierrat, Olivier A, Collie, Gavin W, Box, Gary M, Bright, Michael D, Gowan, Sharon, Hayes, Angela, Rodrigues, Matthew J, Shetty, Kartika N, Carter, Michael, Davis, Owen A, Henley, Alan T, Innocenti, Paolo, Johnson, Louise D, Liu, Manjuan, de Klerk, Selby, Le Bihan, Yann-Vaï, Lloyd, Matthew G, McAndrew, P. Craig, Shehu, Erald, Talbot, Rachel, Woodward, Hannah L, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M, Raynaud, Florence I, Rossanese, Olivia W, Hoelder, Swen

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5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit von Mahy, William, Willis, Nicky J, Zhao, Yuguang, Woodward, Hannah L, Svensson, Fredrik, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Hillier, James, Kjær, Svend, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Jones, E. Yvonne, Fish, Paul V

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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit von Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.

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Screening of a Custom-Designed Acid Fragment Library Identifies 1‑Phenylpyrroles and 1‑Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity von Mahy, William, Patel, Mikesh, Steadman, David, Woodward, Hannah L, Atkinson, Benjamin N, Svensson, Fredrik, Willis, Nicky J, Flint, Alister, Papatheodorou, Dimitra, Zhao, Yuguang, Vecchia, Luca, Ruza, Reinis R, Hillier, James, Frew, Sarah, Monaghan, Amy, Costa, Artur, Bictash, Magda, Walter, Magnus W, Jones, E. Yvonne, Fish, Paul V

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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4‑d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N 2‑(2-... von Woodward, Hannah L, Innocenti, Paolo, Cheung, Kwai-Ming J, Hayes, Angela, Roberts, Jennie, Henley, Alan T, Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M, Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M, Raynaud, Florence I, Eccles, Suzanne A, Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

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Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives von Atkinson, Benjamin N, Woodward, Hannah L, Sipthorp, James, Fish, Paul V

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Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays von Pierrat, Olivier A., Liu, Manjuan, Collie, Gavin W., Shetty, Kartika, Rodrigues, Matthew J., Le Bihan, Yann-Vaï, Gunnell, Emma A., McAndrew, P. Craig, Stubbs, Mark, Rowlands, Martin G., Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R., Cheung, Kwai-Ming J., Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A., Lloyd, Matthew G., Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I., Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W., Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L. M.

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Molecular Distribution, 13C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids von Aponte, Jose C., Woodward, Hannah K., Abreu, Neyda M., Elsila, Jamie E., Dworkin, Jason P.

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Rapid Discovery of Pyrido[3,4‑d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach von Innocenti, Paolo, Woodward, Hannah L, Solanki, Savade, Naud, Sébastien, Westwood, Isaac M, Cronin, Nora, Hayes, Angela, Roberts, Jennie, Henley, Alan T, Baker, Ross, Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Matijssen, Berry, Burke, Rosemary, van Montfort, Rob L. M, Raynaud, Florence I, Eccles, Suzanne A, Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

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Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy von Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros

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Structural Analysis and Development of Notum Fragment Screening Hits von Zhao, Yuguang, Mahy, William, Willis, Nicky J, Woodward, Hannah L, Steadman, David, Bayle, Elliott D, Atkinson, Benjamin N, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V, Jones, E Yvonne

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Molecular Distribution, 13 C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids von Aponte, José C, Woodward, Hannah K, Abreu, Neyda M, Elsila, Jamie E, Dworkin, Jason P

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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-E... von Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen

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The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April - June 2021 von Major-Smith, Daniel, Matthews, Sarah, Breeze, Thomas, Crawford, Michael, Woodward, Hannah, Wells, Nicholas, Mitchell, Ruth, Molloy, Lynn, Northstone, Kate, Timpson, Nicholas John

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The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 von Major-Smith, Daniel, Matthews, Sarah, Breeze, Thomas, Crawford, Michael, Woodward, Hannah, Wells, Nicholas, Mitchell, Ruth, Molloy, Lynn, Northstone, Kate, Timpson, Nicholas John

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The future of cattle veterinary practice: insights from a qualitative study von Woodward, Hannah, Cobb, Kate, Remnant, John

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Synthesis of mucin-type O-glycan probes as aminopropyl glycosides von Benito-Alifonso, David, Jones, Rachel A, Tran, Anh-Tuan, Woodward, Hannah, Smith, Nichola, Galan, M Carmen

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