First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation von Romee, Rizwan, Cooley, Sarah, Berrien-Elliott, Melissa M., Westervelt, Peter, Verneris, Michael R., Wagner, John E., Weisdorf, Daniel J., Blazar, Bruce R., Ustun, Celalettin, DeFor, Todd E., Vivek, Sithara, Peck, Lindsey, DiPersio, John F., Cashen, Amanda F., Kyllo, Rachel, Musiek, Amy, Schaffer, András, Anadkat, Milan J., Rosman, Ilana, Miller, Daniel, Egan, Jack O., Jeng, Emily K., Rock, Amy, Wong, Hing C., Fehniger, Todd A., Miller, Jeffrey S.

Volltext

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells von Burrack, Kristina S., Huggins, Matthew A., Taras, Emily, Dougherty, Philip, Henzler, Christine M., Yang, Rendong, Alter, Sarah, Jeng, Emily K., Wong, Hing C., Felices, Martin, Cichocki, Frank, Miller, Jeffrey S., Hart, Geoffrey T., Johnson, Aaron J., Jameson, Stephen C., Hamilton, Sara E.

Volltext

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models von Rhode, Peter R, Egan, Jack O, Xu, Wenxin, Hong, Hao, Webb, Gabriela M, Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C, Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B, Jeng, Emily K, Cai, Weibo, Wong, Hing C

Volltext

Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion von Gomes-Giacoia, Evan, Miyake, Makito, Goodison, Steve, Sriharan, Aravindhan, Zhang, Ge, You, Lijing, Egan, Jack O, Rhode, Peter R, Parker, Alexander S, Chai, Karl X, Wong, Hing C, Rosser, Charles J

Volltext

Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation von Seibenhener, M. Lamar, Babu, Jeganathan Ramesh, Geetha, Thangiah, Wong, Hing C., Krishna, N. Rama, Wooten, Marie W.

Volltext

Novel Human Interleukin-15 Agonists von Zhu, Xiaoyun, Marcus, Warren D, Xu, Wenxin, Lee, Hyung-il, Han, Kaiping, Egan, Jack O, Yovandich, Jason L, Rhode, Peter R, Wong, Hing C

Volltext

Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled von Wong, Hing-C., Bourdelas, Audrey, Krauss, Anke, Lee, Ho-Jin, Shao, Youming, Wu, Dianqing, Mlodzik, Marek, Shi, De-Li, Zheng, Jie

Volltext

A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice von Zhu, Xiaoyun, Li, Qiongzhen, George, Varghese, Spanoudis, Catherine, Gilkes, Crystal, Shrestha, Niraj, Liu, Bai, Kong, Lin, You, Lijing, Echeverri, Christian, Li, Liying, Wang, Zheng, Chaturvedi, Pallavi, Muniz, Gabriela J, Egan, Jack O, Rhode, Peter R, Wong, Hing C

Volltext

Immuno-PET of tissue factor in pancreatic cancer von Hong, Hao, Zhang, Yin, Nayak, Tapas R, Engle, Jonathan W, Wong, Hing C, Liu, Bai, Barnhart, Todd E, Cai, Weibo

Volltext

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex von Jochems, Caroline, Tritsch, Sarah R., Knudson, Karin M., Gameiro, Sofia R., Rumfield, Claire Smalley, Pellom, Samuel T., Morillon, Y. Maurice, Newman, Robby, Marcus, Warren, Szeto, Christopher, Rabizadeh, Shahrooz, Wong, Hing C., Soon-Shiong, Patrick, Schlom, Jeffrey

Volltext

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery von Tang, Li, Zheng, Yiran, Melo, Mariane Bandeira, Mabardi, Llian, Castaño, Ana P, Xie, Yu-Qing, Li, Na, Kudchodkar, Sagar B, Wong, Hing C, Jeng, Emily K, Maus, Marcela V, Irvine, Darrell J

Volltext

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles von Webb, Gabriela M., Li, Shengbin, Mwakalundwa, Gwantwa, Folkvord, Joy M., Greene, Justin M., Reed, Jason S., Stanton, Jeffery J., Legasse, Alfred W., Hobbs, Theodore, Martin, Lauren D., Park, Byung S., Whitney, James B., Jeng, Emily K., Wong, Hing C., Nixon, Douglas F., Jones, R. Brad, Connick, Elizabeth, Skinner, Pamela J., Sacha, Jonah B.

Volltext

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial von Wrangle, John M, Velcheti, Vamsidhar, Patel, Manish R, Garrett-Mayer, Elizabeth, Hill, Elizabeth G, Ravenel, James G, Miller, Jeffrey S, Farhad, Mohammad, Anderton, Kate, Lindsey, Kathryn, Taffaro-Neskey, Michele, Sherman, Carol, Suriano, Samantha, Swiderska-Syn, Marzena, Sion, Amy, Harris, Joni, Edwards, Andie R, Rytlewski, Julie A, Sanders, Catherine M, Yusko, Erik C, Robinson, Mark D, Krieg, Carsten, Redmond, William L, Egan, Jack O, Rhode, Peter R, Jeng, Emily K, Rock, Amy D, Wong, Hing C, Rubinstein, Mark P

Volltext

Solution Structure of a Double Mutant of the Carboxy-Terminal Dimerization Domain of the HIV-1 Capsid Protein von Wong, Hing C, Shin, Ronald, Krishna, N. Rama

Volltext

Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors von Margolin, Kim, Morishima, Chihiro, Velcheti, Vamsidhar, Miller, Jeffrey S, Lee, Sylvia M, Silk, Ann W, Holtan, Shernan G, Lacroix, Andreanne M, Fling, Steven P, Kaiser, Judith C, Egan, Jack O, Jones, Monica, Rhode, Peter R, Rock, Amy D, Cheever, Martin A, Wong, Hing C, Ernstoff, Marc S

Volltext

An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression von Fujii, Rika, Jochems, Caroline, Tritsch, Sarah R., Wong, Hing C., Schlom, Jeffrey, Hodge, James W.

Volltext

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming von Wagner, Julia A, Rosario, Maximillian, Romee, Rizwan, Berrien-Elliott, Melissa M, Schneider, Stephanie E, Leong, Jeffrey W, Sullivan, Ryan P, Jewell, Brea A, Becker-Hapak, Michelle, Schappe, Timothy, Abdel-Latif, Sara, Ireland, Aaron R, Jaishankar, Devika, King, Justin A, Vij, Ravi, Clement, Dennis, Goodridge, Jodie, Malmberg, Karl-Johan, Wong, Hing C, Fehniger, Todd A

Volltext

Intravesical ALT-803 for BCG-unresponsive Bladder Cancer – A Case Report von Huang, Jeffrey, Schisler, John, Wong, Hing C., Rosser, Charles J., Sterbis, Joseph

Volltext

IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-... von Kim, Peter S, Kwilas, Anna R, Xu, Wenxin, Alter, Sarah, Jeng, Emily K, Wong, Hing C, Schlom, Jeffrey, Hodge, James W

Volltext

Metal toxicity and opportunistic binding of Pb(2+) in proteins von Kirberger, Michael, Wong, Hing C, Jiang, Jie, Yang, Jenny J

Volltext