ATF3, a Hub of the Cellular Adaptive-Response Network, in the Pathogenesis of Diseases: Is Modulation of Inflammation a Unifying Component? von HAI, TSONWIN, WOLFORD, CHRISTOPHER C., CHANG, YI-SEOK

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs von Sun, Hao, Piotrowski, David W, Orr, Suvi T M, Warmus, Joseph S, Wolford, Angela C, Coffey, Steven B, Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D N

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Effects of whole-brain radiation therapy on the blood-brain barrier in immunocompetent and immunocompromised mouse models von Blethen, K E, Sprowls, S A, Arsiwala, T A, Wolford, C P, Panchal, D M, Fladeland, R A, Glass, M J, Dykstra, L P, Kielkowski, B N, Blackburn, J R, Andrick, C J, Lockman, P R

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Coordination of anti-CTLA-4 with whole-brain radiation therapy decreases tumor burden during treatment in a novel syngeneic model of lung cancer brain metastasis von Blethen, K. E., Wolford, C. P., Pecar, G. L., Arsiwala, T. A., Adjeroh, E., Dykstra, L. P., Kielkowski, B. N., Lockman, P. R.

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Transcription factor ATF3 links host adaptive response to breast cancer metastasis von Wolford, Chris C, McConoughey, Stephen J, Jalgaonkar, Swati P, Leon, Marino, Merchant, Anand S, Dominick, Johnna L, Yin, Xin, Chang, Yiseok, Zmuda, Erik J, O'Toole, Sandra A, Millar, Ewan K A, Roller, Stephanie L, Shapiro, Charles L, Ostrowski, Michael C, Sutherland, Robert L, Hai, Tsonwin

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A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling von Li, Rui, Barton, Hugh A., Yates, Phillip D., Ghosh, Avijit, Wolford, Angela C., Riccardi, Keith A., Maurer, Tristan S.

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Possibilities at the Polar beamline with APS-U von Strempfer, J, Kearney, S, Khan, A, Capatina, D, Reininger, R, Shu, D, Wolford, C, Golebiowski, M, Rebuffi, L, Shi, X, Kołodziej, T, Huang, X, Shvyd’ko, Y, Choi, Y, Fabbris, G, Kesgin, I, Ivanyushenkov, Y, Gluskin, E, Haskel, D

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Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process von BARBERA-GUILLEM, Emilio, NYHUS, Julie K, WOLFORD, Chris C, FRIECE, Chad R, SAMPSEL, James W

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The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis von DAN LI, XIN YIN, ZMUDA, Erik J, WOLFORD, Christopher C, XIAOCHENG DONG, WHITE, Morris F, HAI, Tsonwin

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Immunohistochemical Detection of Activating Transcription Factor 3, a Hub of the Cellular Adaptive–Response Network von Hai, Tsonwin, Jalgaonkar, Swati, Wolford, Christopher C., Yin, Xin

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ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells von Yin, Xin, Wolford, Christopher C, Chang, Yi-Seok, McConoughey, Stephen J, Ramsey, Stephen A, Aderem, Alan, Hai, Tsonwin

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Discovery and Preclinical Characterization of 6‑Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]‑1H‑indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-ac... von Cameron, Kimberly O, Kung, Daniel W, Kalgutkar, Amit S, Kurumbail, Ravi G, Miller, Russell, Salatto, Christopher T, Ward, Jessica, Withka, Jane M, Bhattacharya, Samit K, Boehm, Markus, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew, Caspers, Nicole L, Cokorinos, Emily, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Eng, Heather, Fernando, Dilinie P, Frisbie, Richard, Hepworth, David, Landro, James, Mao, Yuxia, Rajamohan, Francis, Reyes, Allan R, Rose, Colin R, Ryder, Tim, Shavnya, Andre, Smith, Aaron C, Tu, Meihua, Wolford, Angela C, Xiao, Jun

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A novel relay method for determining low-clearance values von Di, Li, Trapa, Patrick, Obach, R Scott, Atkinson, Karen, Bi, Yi-An, Wolford, Angela C, Tan, Beijing, McDonald, Thomas S, Lai, Yurong, Tremaine, Larry M

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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Ac... von Ryder, Tim F, Calabrese, Matthew F, Walker, Gregory S, Cameron, Kimberly O, Reyes, Allan R, Borzilleri, Kris A, Delmore, Jake, Miller, Russell, Kurumbail, Ravi G, Ward, Jessica, Kung, Daniel W, Brown, Janice A, Edmonds, David J, Eng, Heather, Wolford, Angela C, Kalgutkar, Amit S

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P.116 Evaluating 2-3 year responses to disease modifying treatment in adults with spinal muscular atrophy von Duong, T., Tang, W., Young, S. Dunaway, Parker, D., Wolford, C., Sampson, J., Day, J.

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Optimization of triazole-based TGR5 agonists towards orally available agents von Futatsugi, Kentaro, Bahnck, Kevin B., Brenner, Martin B., Buxton, Joanne, Chin, Janice E., Coffey, Steven B., Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R., Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M., Jennings, Sandra M., Jiao, Wenhua, Lavergne, Sophie Y., Li, Bryan, Li, Mei, Munchhof, Michael J., Orr, Suvi T. M., Piotrowski, David W., Roush, Nicole S., Sammons, Matthew, Stevens, Benjamin D., Storer, Gregory, Wang, Jian, Warmus, Joseph S., Wei, Liuqing, Wolford, Angela C.

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists von Piotrowski, David W, Futatsugi, Kentaro, Warmus, Joseph S, Orr, Suvi T. M, Freeman-Cook, Kevin D, Londregan, Allyn T, Wei, Liuqing, Jennings, Sandra M, Herr, Michael, Coffey, Steven B, Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y, Chin, Janice E, Hadcock, John R, Brenner, Martin B, Wolford, Angela C, Janssen, Ann M, Roush, Nicole S, Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S, Sharma, Raman, Flynn, Declan A

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IgG-recognizing shed tumor-associated antigens can promote tumor invasion and metastasis von NYHUS, Julie K, WOLFORD, Chris C, FRIECE, Chad R, NELSON, M. Bud, SAMPSEL, James W, BARBERA-GUILLEM, Emilio

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SMA THERAPIES I: P.176Experience using Spinraza to treat adults with spinal muscular atrophy von Day, J., Wolford, C., Macpherson, C., Hagerman, K., Paulose, S., Zeineh, M., Martens, W., McDermott, M., Darras, B., De Vivo, D., Zolkipli Cunningham, Z., Finkel, R., Sampson, J., Duong, T.

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SMA THERAPIES I von Day, J., Wolford, C., Macpherson, C., Hagerman, K., Paulose, S., Zeineh, M., Martens, W., McDermott, M., Darras, B., De Vivo, D., Zolkipli Cunningham, Z., Finkel, R., Sampson, J., Duong, T.

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