Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor von Parry, David, Guzi, Timothy, Shanahan, Frances, Davis, Nicole, Prabhavalkar, Deepa, Wiswell, Derek, Seghezzi, Wolfgang, Paruch, Kamil, Dwyer, Michael P, Doll, Ronald, Nomeir, Amin, Windsor, William, Fischmann, Thierry, Wang, Yaolin, Oft, Martin, Chen, Taiying, Kirschmeier, Paul, Lees, Emma M

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Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters von Nguyen, Theresa V, Ukairo, Okechukwu, Khetani, Salman R, McVay, Michael, Kanchagar, Chitra, Seghezzi, Wolfgang, Ayanoglu, Gulesi, Irrechukwu, Onyi, Evers, Raymond

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Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening von Guzi, Timothy J, Paruch, Kamil, Dwyer, Michael P, Labroli, Marc, Shanahan, Frances, Davis, Nicole, Taricani, Lorena, Wiswell, Derek, Seghezzi, Wolfgang, Penaflor, Ervin, Bhagwat, Bhagyashree, Wang, Wei, Gu, Danling, Hsieh, Yunsheng, Lee, Suining, Liu, Ming, Parry, David

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Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation von Han, Jin-Hwan, Cai, Mingmei, Grein, Jeffery, Perera, Samanthi, Wang, Hongmei, Bigler, Mike, Ueda, Roenna, Rosahl, Thomas W, Pinheiro, Elaine, LaFace, Drake, Seghezzi, Wolfgang, Williams, Sybil M Genther

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Generic Automated Method for Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies von Zhang, Qian, Spellman, Daniel S., Song, Yaoli, Choi, Bernard, Hatcher, Nathan G., Tomazela, Daniela, Beaumont, Maribel, Tabrizifard, Mohammad, Prabhavalkar, Deepa, Seghezzi, Wolfgang, Harrelson, Jane, Bateman, Kevin P.

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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation von WALTER, Annette O, SEGHEZZI, Wolfgang, KORVER, Wouter, SHEUNG, Julie, LEES, Emma

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Corrigendum: Effective Anti-tumor Response by TIGIT Blockade Associated With Fc γ R Engagement and Myeloid Cell Activation von Han, Jin-Hwan, Cai, Mingmei, Grein, Jeffery, Perera, Samanthi, Wang, Hongmei, Bigler, Mike, Ueda, Roenna, Rosahl, Thomas W, Pinheiro, Elaine, LaFace, Drake, Seghezzi, Wolfgang, Williams, Sybil M Genther

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PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys von Li, Wenping, Wang, Yuchuan, Rubins, Daniel, Bennacef, Idriss, Holahan, Marie, Haley, Hyking, Purcell, Mona, Gantert, Liza, Hseih, SuChun, Judo, Michael, Seghezzi, Wolfgang, Zhang, Shuli, van der Veen, Elly L., Lub-de Hooge, Marjolijn N., de Vries, Elisabeth G.E., Evelhoch, Jeffrey L., Klimas, Michael, Hostetler, Eric D.

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1 von Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2 von Labroli, Marc, Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Keertikar, Kartik, Poker, Cory, Rossman, Randall, Duca, Jose S., Fischmann, Thierry O., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors von Zhao, Lianyun, Zhang, Yingxin, Dai, Chaoyang, Guzi, Timothy, Wiswell, Derek, Seghezzi, Wolfgang, Parry, David, Fischmann, Thierry, Siddiqui, M. Arshad

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AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer von Jiang, Ying, Zhang, Yongke, Lees, Emma, Seghezzi, Wolfgang

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain von Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V

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Structure-guided discovery of cyclin-dependent kinase inhibitors von Fischmann, Thierry O., Hruza, Alan, Duca, José S., Ramanathan, Lata, Mayhood, Todd, Windsor, William T., Le, Hung V., Guzi, Timothy J., Dwyer, Michael P., Paruch, Kamil, Doll, Ronald J., Lees, Emma, Parry, David, Seghezzi, Wolfgang, Madison, Vincent

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Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest von Shanahan, Frances, Seghezzi, Wolfgang, Parry, David, Mahony, Daniel, Lees, Emma

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A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells von Kumagai, Hiroyuki, Sato, Noriko, Yamada, Masayuki, Mahony, Daniel, Seghezzi, Wolfgang, Lees, Emma, Arai, Ken-Ichi, Masai, Hisao

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IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance von Mumm, John B., Emmerich, Jan, Zhang, Xueqing, Chan, Ivan, Wu, Lingling, Mauze, Smita, Blaisdell, Steven, Basham, Beth, Dai, Jie, Grein, Jeff, Sheppard, Catherine, Hong, Kyu, Cutler, Collette, Turner, Scott, LaFace, Drake, Kleinschek, Melanie, Judo, Michael, Ayanoglu, Gulesi, Langowski, John, Gu, Danling, Paporello, Brittany, Murphy, Erin, Sriram, Venkataraman, Naravula, Saraswathi, Desai, Bela, Medicherla, Satya, Seghezzi, Wolfgang, McClanahan, Terrill, Cannon-Carlson, Susan, Beebe, Amy M., Oft, Martin

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Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction von Bhagwat, Bhagyashree, Cherwinski, Holly, Sathe, Manjiri, Seghezzi, Wolfgang, McClanahan, Terrill K., de Waal Malefyt, Rene, Willingham, Aarron

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Development of a novel capillary electrophoresis-based approach for detection of anti-drug antibody responses von Zhang, Shuli, Chen, Minchao, Zhou, Siqun, Raoufi, Fahimeh, Wiswell, Derek, Hsieh, SuChun, Seghezzi, Wolfgang

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Cyclin E Associates with Components of the Pre-mRNA Splicing Machinery in Mammalian Cells von Seghezzi, Wolfgang, Chua, Katrin, Shanahan, Frances, Gozani, Or, Reed, Robin, Lees, Emma

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