Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies von Moilanen, Anu-Maarit, Riikonen, Reetta, Oksala, Riikka, Ravanti, Laura, Aho, Eija, Wohlfahrt, Gerd, Nykänen, Pirjo S., Törmäkangas, Olli P., Palvimo, Jorma J., Kallio, Pekka J.

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Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5 von Kinnunen, Sini, Välimäki, Mika, Tölli, Marja, Wohlfahrt, Gerd, Darwich, Rami, Komati, Hiba, Nemer, Mona, Ruskoaho, Heikki

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Sterol binding by OSBP-related protein 1L regulates late endosome motility and function von Vihervaara, Terhi, Uronen, Riikka-Liisa, Wohlfahrt, Gerd, Björkhem, Ingemar, Ikonen, Elina, Olkkonen, Vesa M

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The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket von Suchanek, Monika, Hynynen, Riikka, Wohlfahrt, Gerd, Lehto, Markku, Johansson, Marie, Saarinen, Hannu, Radzikowska, Anna, Thiele, Christoph, Olkkonen, Vesa M

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A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human von Zhou, You, Wohlfahrt, Gerd, Paavola, Jere, Olkkonen, Vesa M.

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Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors von Goswami, Rajeev, Mukherjee, Subhendu, Wohlfahrt, Gerd, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Chandra, Beeram Ravi, Sistla, Ramesh K, Satyam, Leena K, Samiulla, Dodheri S, Moilanen, Anu, Subramanya, Hosahalli S, Ramachandra, Murali

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Novel small molecule inhibitors for prostate-specific antigen von Koistinen, Hannu, Wohlfahrt, Gerd, Mattsson, Johanna M., Wu, Ping, Lahdenperä, Juhani, Stenman, Ulf-Håkan

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Faulty Epithelial Polarity Genes and Cancer von Tervonen, Topi A., Partanen, Johanna I., Saarikoski, Sirkku T., Myllynen, Mikko, Marques, Elsa, Paasonen, Katriina, Moilanen, Anu, Wohlfahrt, Gerd, Kovanen, Panu E., Klefstrom, Juha

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First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis von Karimaa, Mari, Riikonen, Reetta, Kettunen, Henna, Taavitsainen, Päivi, Ramela, Meri, Chrusciel, Marcin, Karlsson, Stefan, Rummakko, Petteri, Simola, Outi, Wohlfahrt, Gerd, Hakulinen, Pasi, Vuorela, Annamari, Joensuu, Heikki, Utriainen, Tapio, Fizazi, Karim, Oksala, Riikka

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Abstract 1250: ODM-208, a novel, small-molecule CYP11A1 inhibitor, demonstrates strong inhibition of steroid biosynthesis and antitumor activity in castration-resistant prostate ca... von Karimaa, Mari, Kettunen, Henna, Ramela, Meri, Mansikka-Savolainen, Suvi, Chrusciel, Marcin, Simola, Outi, Taavitsainen, Päivi, Wohlfahrt, Gerd, Rummakko, Petteri, Vuorela, Annamari, Fizazi, Karim, Oksala, Riikka

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Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21 von Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin

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Predictive proteochemometric models for kinases derived from 3D protein field-based descriptors von Subramanian, Vigneshwari, Prusis, Peteris, Xhaard, Henri, Wohlfahrt, Gerd

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ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity von Holmström, Tim H, Moilanen, Anu-Maarit, Ikonen, Tarja, Björkman, Mari L, Linnanen, Tero, Wohlfahrt, Gerd, Karlsson, Stefan, Oksala, Riikka, Korjamo, Timo, Samajdar, Susanta, Rajagopalan, Srinivasan, Chelur, Shekar, Narayanan, Kishore, Ramachandra, Raghuveer K, Mani, Jiju, Nair, Rashmi, Gowda, Nagaraj, Anthony, Thomas, Dhodheri, Samiulla, Mukherjee, Subhendu, Ujjinamatada, Ravi K, Srinivas, Nanduri, Ramachandra, Murali, Kallio, Pekka J

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Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects von Cortés-Ciriano, Isidro, Ain, Qurrat Ul, Subramanian, Vigneshwari, Lenselink, Eelke B, Méndez-Lucio, Oscar, IJzerman, Adriaan P, Wohlfahrt, Gerd, Prusis, Peteris, Malliavin, Thérèse E, van Westen, Gerard J. P, Bender, Andreas

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Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers von Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, Senaiar, Ramesh S, Mukherjee, Subhendu, Jaleel, Mahaboobi, Marappan, Sivapriya, N R, Raghavendra, Renukappa, Girish Aggunda, B, Aravind A, R, Naveen Kumar, Reddy, Venkata Siva, Babu, Asha, Srinivas, Akhila, Yadlapalli, Prasad, Gore, Suraj T, Hemasankar, Pathange, Dey, Mamon, S, Samiulla D, Naik, Chandranath D, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Myllymäki, Mikko, Wohlfahrt, Gerd, Ramachandra, Murali, Samajdar, Susanta

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Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity von Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy

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Structure and phospholipid transfer activity of human PLTP: analysis by molecular modeling and site-directed mutagenesis von Huuskonen, J, Wohlfahrt, G, Jauhiainen, M, Ehnholm, C, Teleman, O, Olkkonen, V M

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Discovery and development of ODM-204: A Novel nonsteroidal compound for the treatment of castration-resistant prostate cancer by blocking the androgen receptor and inhibiting CYP17... von Oksala, Riikka, Moilanen, Anu, Riikonen, Reetta, Rummakko, Petteri, Karjalainen, Arja, Passiniemi, Mikko, Wohlfahrt, Gerd, Taavitsainen, Päivi, Malmström, Chira, Ramela, Meri, Metsänkylä, Hanna-Maija, Huhtaniemi, Riikka, Kallio, Pekka J., Mustonen, Mika VJ

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CYP11A1 inhibition as a therapeutic approach for the treatment of castration resistant prostate cancer von Oksala, Riikka, Karimaa, Mari, Simola, Outi, Ramela, Meri, Riikonen, Reetta, Vehmaan-Kreula, Pirjo, Rummakko, Petteri, Wohlfahrt, Gerd, Kallio, Pekka, Mustonen, Mika VJ

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Analysis of pH-dependent elements in proteins: Geometry and properties of pairs of hydrogen-bonded carboxylic acid side-chains von Wohlfahrt, Gerd

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