Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides von Mudd, Gemma E., Stanway, Steven J., Witty, David R., Thomas, Alex, Baldo, Silvia, Bond, Andrew D., Beswick, Paul, Highton, Adrian

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Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia von Witty, David R, Alvaro, Giuseppe, Derjean, Dominique, Giblin, Gerard M. P, Gunn, Kevin, Large, Charles, Macpherson, David T, Morisset, Valerie, Owen, Davina, Palmer, Joanne, Rugiero, Francois, Tate, Simon, Hinckley, Christopher A, Naik, Himanshu

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BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism von Hurov, Kristen, Lahdenranta, Johanna, Upadhyaya, Punit, Haines, Eric, Cohen, Heather, Repash, Elizabeth, Kanakia, Drasti, Ma, Jun, Kristensson, Julia, You, Fanglei, Campbell, Carly, Witty, David, Kelly, Mike, Blakemore, Stephen, Jeffrey, Phil, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas

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Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design von Singh, Onkar, Shillings, Anthony, Craggs, Peter, Wall, Ian, Rowland, Paul, Skarzynski, Tadeusz, Hobbs, Clare I., Hardwick, Phil, Tanner, Rob, Blunt, Michelle, Witty, David R., Smith, Kathrine J.

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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase von Brown, Murray J., Carter, Paul S., Fenwick, Ashley E., Fosberry, Andrew P., Hamprecht, Dieter W., Hibbs, Martin J., Jarvest, Richard L., Mensah, Lucy, Milner, Peter H., O'Hanlon, Peter J., Pope, Andrew J., Richardson, Christine M., West, Andrew, Witty, David R.

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Unified Route to the Palmarumycin and Preussomerin Natural Products. Enantioselective Synthesis of (−)-Preussomerin G von Barrett, Anthony G. M, Blaney, Frank, Campbell, Andrew D, Hamprecht, Dieter, Meyer, Thorsten, White, Andrew J. P, Witty, David, Williams, David J

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists von AHMED, Mahmood, BRIGGS, Michael A, JOHNSON, Christopher N, MEDHURST, Andrew D, MITCHELL, Darren J, MOSS, Stephen F, POWLES, Jenifer, SEAL, Jon T, STEAN, Tania O, STEMP, Geoffrey, THOMPSON, Mervyn, TRAIL, Brenda, BROMIDGE, Steven M, UPTON, Neil, WINBORN, Kim, WITTY, David R, BUCK, Tania, CAMPBELL, Lorraine, DEEKS, Nigel J, GARNER, Ashley, GORDON, Laurie, HAMPRECHT, Dieter W, HOLLAND, Vicky

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Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept von Giblin, Gerard, Heseltine, Adrian, Kiesman, William, MacPherson, David, Ramsden, James, Vadali, Ravi, Williams, Michael, Witty, David

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SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849 von Witty, David R., Bateson, John H., Hervieu, Guillaume J., Jeffrey, Phillip, Johnson, Christopher N., Muir, Alison I., O’Hanlon, Peter J., Stemp, Geoffrey, Stevens, Alex J., Thewlis, Kevin M., Wilson, Shelagh, Winborn, Kim Y.

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Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists von TRANI, Giancarlo, BADDELEY, Stuart M, QUINN, Leann P, RAY, Alison M, RIVERS, Dean A, STEAN, Tania O, STEMP, Geoffrey, TRAIL, Brenda K, WITTY, David R, BRIGGS, Michael A, CHUANG, Tsu T, DEEKS, Nigel J, JOHNSON, Christopher N, KHAZRAGI, Abir A, MEAD, Tania L, MEDHURST, Andrew D, MILNER, Peter H

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Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849 von Witty, David R., Bateson, John, Hervieu, Guillaume J., Al-Barazanji, Kamal, Jeffrey, Phillip, Hamprecht, Dieter, Haynes, Andrea, Johnson, Christopher N., Muir, Alison I., O’Hanlon, Peter J., Stemp, Geoffrey, Stevens, Alex J., Thewlis, Kevin, Winborn, Kim Y.

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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues von Jarvest, Richard L, Armstrong, Sula A, Berge, John M, Brown, Pamela, Elder, John S, Brown, Murray J, Copley, Royston C.B, Forrest, Andrew K, Hamprecht, Dieter W, O'Hanlon, Peter J, Mitchell, Darren J, Rittenhouse, Stephen, Witty, David R

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P4-327: Effects of the novel 5-HT6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition von Ray, Alison M, Hirst, Warren D, Ahmed, Mahmood, Johnson, Christopher N, Witty, David R, Sunter, David, Quinn, Leann P, Stean, Tania O, Trail, Brenda K, Foley, Andrew, Upton, Neil, Medhurst, Andrew D, Chuang, Tsu T

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Inhibition of HIV replication by amino-sugar derivatives von Fleet, George W.J., Karpas, Abraham, Dwek, Raymond A., Fellows, Linda E., Tyms, A.S., Petursson, Sigthor, Namgoong, Sung K., Ramsden, Nigel G., Smith, Paul W., Son, Jong Chan, Wilson, Francis, Witty, David R., Jacob, Gary S., Rademacher, Thomas W.

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A practical synthesis of deoxymannojirimycin and of (2s,3R,4R,5R)-3,4,5-trihydroxypipecolic acid from D-glucose von Fleet, George W.J., Ramsden, Nigel G., Witty, David R

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PROCESS FOR THE PREPARATION OF AN N-ACYLETHANOLAMIDE DERIVATIVE von LATHBURY, David, WITTY, David

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One-Pot Synthesis of N,N’-Bisacylimidazolidines; Potential New Acyl Anion Equivalents von Coldham, Iain, Houdayer, Philippe M. A., Judkins, Robert A., Witty, David R.

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A gas detector cell von Andrew David Witty

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Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine von Nichols, Paula L., Brand, Jonathan, Briggs, Michael, D’Angeli, Mathilde, Farge, Jennifer, Garland, Stephen L., Goldsmith, Paul, Hutchings, Rio, Kilford, Ian, Li, Ho Y., MacPherson, David, Nimmo, Fiona, Sanderson, Francis Dominic, Sehmi, Sanjeet, Shuker, Nicola, Skidmore, John, Stott, Michael, Sweeting, Jennifer, Tajuddin, Hasmi, Takle, Andrew K., Trani, Giancarlo, Wall, Ian D., Ward, Robert, Wilson, David M., Witty, David

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT 6 receptor antagonists von Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.

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