BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas von Pfister, Stefan, Janzarik, Wibke G, Remke, Marc, Ernst, Aurélie, Werft, Wiebke, Becker, Natalia, Toedt, Grischa, Wittmann, Andrea, Kratz, Christian, Olbrich, Heike, Ahmadi, Rezvan, Thieme, Barbara, Joos, Stefan, Radlwimmer, Bernhard, Kulozik, Andreas, Pietsch, Torsten, Herold-Mende, Christel, Gnekow, Astrid, Reifenberger, Guido, Korshunov, Andrey, Scheurlen, Wolfram, Omran, Heymut, Lichter, Peter

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Adult Medulloblastoma Comprises Three Major Molecular Variants von Remke, Marc, Hielscher, Thomas, Northcott, Paul A, Witt, Hendrik, Ryzhova, Marina, Wittmann, Andrea, Benner, Axel, von Deimling, Andreas, Scheurlen, Wolfram, Perry, Arie, Croul, Sidney, Kulozik, Andreas E, Lichter, Peter, Taylor, Michael D, Pfister, Stefan M, Korshunov, Andrey

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Molecular Staging of Intracranial Ependymoma in Children and Adults von Korshunov, Andrey, Witt, Hendrik, Hielscher, Thomas, Benner, Axel, Remke, Marc, Ryzhova, Marina, Milde, Till, Bender, Sebastian, Wittmann, Andrea, Schöttler, Anna, Kulozik, Andreas E, Witt, Olaf, von Deimling, Andreas, Lichter, Peter, Pfister, Stefan

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Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci von PFISTER, Stefan, REMKE, Marc, KULOZIK, Andreas, REIFENBERGER, Guido, RUTKOWSKI, Stefan, WIESTLER, Otmar D, RADLWIMMER, Bernhard, SCHEURLEN, Wolfram, LICHTER, Peter, KORSHUNOV, Andrey, BENNER, Axel, MENDRZYK, Frank, TOEDT, Grischa, FELSBERG, Jörg, WITTMANN, Andrea, DEVENS, Frauke, GERBER, Nicolas U, JOOS, Stefan

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FSTL5 Is a Marker of Poor Prognosis in Non-WNT/Non-SHH Medulloblastoma von Remke, Marc, Hielscher, Thomas, Korshunov, Andrey, Northcott, Paul A, Bender, Sebastian, Kool, Marcel, Westermann, Frank, Benner, Axel, Cin, Huriye, Ryzhova, Marina, Sturm, Dominik, Witt, Hendrik, Haag, Daniel, Toedt, Grischa, Wittmann, Andrea, Schöttler, Anna, von Bueren, André O, von Deimling, Andreas, Rutkowski, Stefan, Scheurlen, Wolfram, Kulozik, Andreas E, Taylor, Michael D, Lichter, Peter, Pfister, Stefan M

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Adult and Pediatric Medulloblastomas Are Genetically Distinct and Require Different Algorithms for Molecular Risk Stratification von KORSHUNOV, Andrey, REMKE, Marc, REIFENBERGER, Guido, RUTKOWSKI, Stefan, SCHEURLEN, Wolfram, KULOZIK, Andreas E, VON DEIMLING, Andreas, LICHTER, Peter, PFISTER, Stefan M, WERFT, Wiebke, BENNER, Axel, RYZHOVA, Marina, WITT, Hendrik, STURM, Dominik, WITTMANN, Andrea, SCHÖTTLER, Anna, FELSBERG, Jörg

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TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma von PFAFF, Elke, REMKE, Marc, GRAF, Norbert, KULOZIK, Andreas E, WITT, Olaf, SCHEURLEN, Wolfram, VON DEIMLING, Andreas, RUTKOWSKI, Stefan, TAYLOR, Michael D, TABORI, Uri, LICHTER, Peter, KORSHUNOV, Andrey, STURM, Dominik, PFISTER, Stefan M, BENNER, Axel, WITT, Hendrik, MILDE, Till, VON BUEREN, André O, WITTMANN, Andrea, SCHÖTTLER, Anna, JORCH, Norbert

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Biological and clinical heterogeneity of MYCN-amplified medulloblastoma von Korshunov, Andrey, Remke, Marc, Kool, Marcel, Hielscher, Thomas, Northcott, Paul A., Williamson, Dan, Pfaff, Elke, Witt, Hendrik, Jones, David T. W., Ryzhova, Marina, Cho, Yoon-Jae, Wittmann, Andrea, Benner, Axel, Weiss, William A., von Deimling, Andreas, Scheurlen, Wolfram, Kulozik, Andreas E., Clifford, Steven C., Peter Collins, V., Westermann, Frank, Taylor, Michael D., Lichter, Peter, Pfister, Stefan M.

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Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma von Tzaridis, Theophilos, Milde, Till, Pajtler, Kristian W, Bender, Sebastian, Jones, David T W, Müller, Simone, Wittmann, Andrea, Schlotter, Magdalena, Kulozik, Andreas E, Lichter, Peter, Peter Collins, V, Witt, Olaf, Kool, Marcel, Korshunov, Andrey, Pfister, Stefan M, Witt, Hendrik

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Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medullobla... von Pfister, Stefan, Remke, Marc, Toedt, Grischa, Werft, Wiebke, Benner, Axel, Mendrzyk, Frank, Wittmann, Andrea, Devens, Frauke, von Hoff, Katja, Rutkowski, Stefan, Kulozik, Andreas, Radlwimmer, Bernhard, Scheurlen, Wolfram, Lichter, Peter, Korshunov, Andrey

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Chronic inflammatory effects of in vivo irradiation of the murine heart on endothelial cells mimic mechanisms involved in atherosclerosis von Wittmann, Andrea, Bartels, Anna, Alkotub, Bayan, Bauer, Lisa, Kafshgari, Morteza Hasanzadeh, Multhoff, Gabriele

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Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes von Johann, Pascal D., Erkek, Serap, Zapatka, Marc, Kerl, Kornelius, Buchhalter, Ivo, Hovestadt, Volker, Jones, David T.W., Sturm, Dominik, Hermann, Carl, Segura Wang, Maia, Korshunov, Andrey, Rhyzova, Marina, Gröbner, Susanne, Brabetz, Sebastian, Chavez, Lukas, Bens, Susanne, Gröschel, Stefan, Kratochwil, Fabian, Wittmann, Andrea, Sieber, Laura, Geörg, Christina, Wolf, Stefan, Beck, Katja, Oyen, Florian, Capper, David, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, von Deimling, Andreas, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Ebinger, Martin, Shalaby, Tarek, Grotzer, Michael, Sumerauer, David, Zamecnik, Josef, Mora, Jaume, Jabado, Nada, Taylor, Michael D., Huang, Annie, Aronica, Eleonora, Bertoni, Anna, Radlwimmer, Bernhard, Pietsch, Torsten, Schüller, Ulrich, Schneppenheim, Reinhard, Northcott, Paul A., Korbel, Jan O., Siebert, Reiner, Frühwald, Michael C., Lichter, Peter, Eils, Roland, Gajjar, Amar, Hasselblatt, Martin, Pfister, Stefan M., Kool, Marcel

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Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition von Kool, Marcel, Jones, David T.W., Jäger, Natalie, Northcott, Paul A., Pugh, Trevor J., Hovestadt, Volker, Piro, Rosario M., Esparza, L. Adriana, Markant, Shirley L., Remke, Marc, Milde, Till, Bourdeaut, Franck, Ryzhova, Marina, Sturm, Dominik, Pfaff, Elke, Stark, Sebastian, Hutter, Sonja, Şeker-Cin, Huriye, Johann, Pascal, Bender, Sebastian, Schmidt, Christin, Rausch, Tobias, Shih, David, Reimand, Jüri, Sieber, Laura, Wittmann, Andrea, Linke, Linda, Witt, Hendrik, Weber, Ursula D., Zapatka, Marc, König, Rainer, Beroukhim, Rameen, Bergthold, Guillaume, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Schmidt, Sabine, Wolf, Stephan, Lawerenz, Chris, Bartholomae, Cynthia C., von Kalle, Christof, Unterberg, Andreas, Herold-Mende, Christel, Hofer, Silvia, Kulozik, Andreas E., von Deimling, Andreas, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Hasselblatt, Martin, Crawford, John R., Grant, Gerald A., Jabado, Nada, Perry, Arie, Cowdrey, Cynthia, Croul, Sydney, Zadeh, Gelareh, Korbel, Jan O., Doz, Francois, Delattre, Olivier, Bader, Gary D., McCabe, Martin G., Collins, V. Peter, Kieran, Mark W., Cho, Yoon-Jae, Pomeroy, Scott L., Witt, Olaf, Brors, Benedikt, Taylor, Michael D., Schüller, Ulrich, Korshunov, Andrey, Eils, Roland, Wechsler-Reya, Robert J., Lichter, Peter, Pfister, Stefan M.

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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma von Northcott, Paul A., Lee, Catherine, Zichner, Thomas, Stütz, Adrian M., Erkek, Serap, Kawauchi, Daisuke, Shih, David J. H., Hovestadt, Volker, Zapatka, Marc, Sturm, Dominik, Jones, David T. W., Kool, Marcel, Remke, Marc, Cavalli, Florence M. G., Zuyderduyn, Scott, Bader, Gary D., VandenBerg, Scott, Esparza, Lourdes Adriana, Ryzhova, Marina, Wang, Wei, Wittmann, Andrea, Stark, Sebastian, Sieber, Laura, Seker-Cin, Huriye, Linke, Linda, Kratochwil, Fabian, Jäger, Natalie, Buchhalter, Ivo, Imbusch, Charles D., Zipprich, Gideon, Raeder, Benjamin, Schmidt, Sabine, Diessl, Nicolle, Wolf, Stephan, Wiemann, Stefan, Brors, Benedikt, Lawerenz, Chris, Eils, Jürgen, Warnatz, Hans-Jörg, Risch, Thomas, Yaspo, Marie-Laure, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Turányi, Eszter, Hauser, Peter, Sanden, Emma, Darabi, Anna, Siesjö, Peter, Sterba, Jaroslav, Zitterbart, Karel, Sumerauer, David, van Sluis, Peter, Versteeg, Rogier, Volckmann, Richard, Koster, Jan, Schuhmann, Martin U., Ebinger, Martin, Grimes, H. Leighton, Robinson, Giles W., Gajjar, Amar, Mynarek, Martin, von Hoff, Katja, Rutkowski, Stefan, Pietsch, Torsten, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Kulozik, Andreas E., von Deimling, Andreas, Witt, Olaf, Eils, Roland, Gilbertson, Richard J., Korshunov, Andrey, Taylor, Michael D., Lichter, Peter, Korbel, Jan O., Wechsler-Reya, Robert J., Pfister, Stefan M.

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Dissecting the genomic complexity underlying medulloblastoma von Jones, David T. W., Jäger, Natalie, Kool, Marcel, Zichner, Thomas, Hutter, Barbara, Sultan, Marc, Cho, Yoon-Jae, Pugh, Trevor J., Hovestadt, Volker, Stütz, Adrian M., Rausch, Tobias, Warnatz, Hans-Jörg, Ryzhova, Marina, Bender, Sebastian, Sturm, Dominik, Pleier, Sabrina, Cin, Huriye, Pfaff, Elke, Sieber, Laura, Wittmann, Andrea, Remke, Marc, Witt, Hendrik, Hutter, Sonja, Tzaridis, Theophilos, Weischenfeldt, Joachim, Raeder, Benjamin, Avci, Meryem, Amstislavskiy, Vyacheslav, Zapatka, Marc, Weber, Ursula D., Wang, Qi, Lasitschka, Bärbel, Bartholomae, Cynthia C., Schmidt, Manfred, von Kalle, Christof, Ast, Volker, Lawerenz, Chris, Eils, Jürgen, Kabbe, Rolf, Benes, Vladimir, van Sluis, Peter, Koster, Jan, Volckmann, Richard, Shih, David, Betts, Matthew J., Russell, Robert B., Coco, Simona, Paolo Tonini, Gian, Schüller, Ulrich, Hans, Volkmar, Graf, Norbert, Kim, Yoo-Jin, Monoranu, Camelia, Roggendorf, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Milde, Till, Kulozik, Andreas E., von Deimling, Andreas, Witt, Olaf, Maass, Eberhard, Rössler, Jochen, Ebinger, Martin, Schuhmann, Martin U., Frühwald, Michael C., Hasselblatt, Martin, Jabado, Nada, Rutkowski, Stefan, von Bueren, André O., Williamson, Dan, Clifford, Steven C., McCabe, Martin G., Peter Collins, V., Wolf, Stephan, Wiemann, Stefan, Lehrach, Hans, Brors, Benedikt, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Northcott, Paul A., Taylor, Michael D., Meyerson, Matthew, Pomeroy, Scott L., Yaspo, Marie-Laure, Korbel, Jan O., Korshunov, Andrey, Eils, Roland, Pfister, Stefan M., Lichter, Peter

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Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features von Deng, Maximilian Y., Sill, Martin, Chiang, Jason, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Monoranu, Camelia-Maria, Milde, Till, Wittmann, Andrea, Hartmann, Christian, Sommer, Clemens, Paulus, Werner, Gärtner, Jutta, Brück, Wolfgang, Rüdiger, Thomas, Leipold, Alfred, Jaunmuktane, Zane, Brandner, Sebastian, Giangaspero, Felice, Nozza, Paolo, Mora, Jaume, Morales la Madrid, Andres, Cruz Martinez, Ofelia, Hansford, Jordan R., Pietsch, Torsten, Tietze, Anna, Hernáiz-Driever, Pablo, Stoler, Iris, Capper, David, Korshunov, Andrey, Ellison, David W., von Deimling, Andreas, Pfister, Stefan M., Sahm, Felix, Jones, David T. W.

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HGG-07. OVEREXPRESSION OF A PLAG-FAMILY TRANSCRIPTION FACTOR DURING MURINE BRAIN DEVELOPMENT CAUSES BRAIN TUMOR FORMATION von Vaillant, Jan, Wittmann, Andrea, Keck, Michaela-Kristina, Rozowsky, Jacob S, Filbin, Mariella G, Pfister, Stefan M, Jones, David T W, Kutscher, Lena M

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ETMR-07. OVEREXPRESSION OF THE PLAG-GENE FAMILY MEMBER PLAG1 DURING MURINE BRAIN DEVELOPMENT LEADS TO ABERRANT EXPRESSION OF IMPRINTED GENES AND THE FORMATION OF MIDLINE BRAIN TUMO... von Vaillant, Jan, Keck, Michaela-Kristina, Wittmann, Andrea, Hofmann, Nina, Sievers, Philipp, Chen, Angela, Rozowsky, Jacob S, Filbin, Mariella G, Beroukhim, Rameen, Bandopadhahay, Pratiti, Jones, David T W, Kutscher, Lena M

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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum von Alhalabi, Karam T., Stichel, Damian, Sievers, Philipp, Peterziel, Heike, Sommerkamp, Alexander C., Sturm, Dominik, Wittmann, Andrea, Sill, Martin, Jäger, Natalie, Beck, Pengbo, Pajtler, Kristian W., Snuderl, Matija, Jour, George, Delorenzo, Michael, Martin, Allison M., Levy, Adam, Dalvi, Nagma, Hansford, Jordan R., Gottardo, Nicholas G., Uro-Coste, Emmanuelle, Maurage, Claude-Alain, Godfraind, Catherine, Vandenbos, Fanny, Pietsch, Torsten, Kramm, Christof, Filippidou, Maria, Kattamis, Antonis, Jones, Chris, Øra, Ingrid, Mikkelsen, Torben Stamm, Zapotocky, Michal, Sumerauer, David, Scheie, David, McCabe, Martin, Wesseling, Pieter, Tops, Bastiaan B. J., Kranendonk, Mariëtte E. G., Karajannis, Matthias A., Bouvier, Nancy, Papaemmanuil, Elli, Dohmen, Hildegard, Acker, Till, von Hoff, Katja, Schmid, Simone, Miele, Evelina, Filipski, Katharina, Kitanovski, Lidija, Krskova, Lenka, Gojo, Johannes, Haberler, Christine, Alvaro, Frank, Ecker, Jonas, Selt, Florian, Milde, Till, Witt, Olaf, Oehme, Ina, Kool, Marcel, von Deimling, Andreas, Korshunov, Andrey, Pfister, Stefan M., Sahm, Felix, Jones, David T. W.

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Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma von Witt, Hendrik, Mack, Stephen C., Ryzhova, Marina, Bender, Sebastian, Sill, Martin, Isserlin, Ruth, Benner, Axel, Hielscher, Thomas, Milde, Till, Remke, Marc, Jones, David T.W., Northcott, Paul A., Garzia, Livia, Bertrand, Kelsey C., Wittmann, Andrea, Yao, Yuan, Roberts, Stephen S., Massimi, Luca, Van Meter, Tim, Weiss, William A., Gupta, Nalin, Grajkowska, Wiesia, Lach, Boleslaw, Cho, Yoon-Jae, von Deimling, Andreas, Kulozik, Andreas E., Witt, Olaf, Bader, Gary D., Hawkins, Cynthia E., Tabori, Uri, Guha, Abhijit, Rutka, James T., Lichter, Peter, Korshunov, Andrey, Taylor, Michael D., Pfister, Stefan M.

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