Structure-Function Relationships of the G Domain, a Canonical Switch Motif von Wittinghofer, Alfred, Vetter, Ingrid R

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GEFs and GAPs: Critical Elements in the Control of Small G Proteins von Bos, Johannes L., Rehmann, Holger, Wittinghofer, Alfred

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Structure of the human BBSome core complex von Klink, Björn Udo, Gatsogiannis, Christos, Hofnagel, Oliver, Wittinghofer, Alfred, Raunser, Stefan

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A recombinant BBSome core complex and how it interacts with ciliary cargo von Klink, Björn Udo, Zent, Eldar, Juneja, Puneet, Kuhlee, Anne, Raunser, Stefan, Wittinghofer, Alfred

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A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins von Gotthardt, Katja, Lokaj, Mandy, Koerner, Carolin, Falk, Nathalie, Gießl, Andreas, Wittinghofer, Alfred

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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity von Fansa, Eyad Kalawy, Kösling, Stefanie Kristine, Zent, Eldar, Wittinghofer, Alfred, Ismail, Shehab

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The Guanine Nucleotide-Binding Switch in Three Dimensions von Vetter, Ingrid R., Wittinghofer, Alfred

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Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It’s Down von Hobbs, G. Aaron, Wittinghofer, Alfred, Der, Channing J.

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GTP-induced conformational changes in septins and implications for function von Sirajuddin, Minhajuddin, Farkasovsky, Marian, Zent, Eldar, Wittinghofer, Alfred

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Identification of pyrazolopyridazinones as PDEδ inhibitors von Papke, Björn, Murarka, Sandip, Vogel, Holger A, Martín-Gago, Pablo, Kovacevic, Marija, Truxius, Dina C, Fansa, Eyad K, Ismail, Shehab, Zimmermann, Gunther, Heinelt, Kaatje, Schultz-Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert, Bastiaens, Philippe I.H.

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new family of RhoGEFs activates the Rop molecular switch in plants von Berken, A, Thomas, C, Wittinghofer, A

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Capturing cyclic nucleotides in action: snapshots from crystallographic studies von Rehmann, Holger, Wittinghofer, Alfred, Bos, Johannes L

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The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues von Scrima, Andrea, Thomas, Christoph, Deaconescu, Delia, Wittinghofer, Alfred

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The regulation of mDia1 by autoinhibition and its release by Rho•GTP von Lammers, Michael, Rose, Rolf, Scrima, Andrea, Wittinghofer, Alfred

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Structural Insights into HypB, a GTP-binding Protein That Regulates Metal Binding von Gasper, Raphael, Scrima, Andrea, Wittinghofer, Alfred

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Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms von Rocks, Oliver, Peyker, Anna, Kahms, Martin, Verveer, Peter J, Koerner, Carolin, Lumbierres, Maria, Kuhlmann, Jůrgen, Waldmann, Herbert, Wittinghofer, Alfred, Bastiaens, Philippe I. H

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Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 von Ismail, Shehab A, Chen, Yong-Xiang, Miertzschke, Mandy, Vetter, Ingrid R, Koerner, Carolin, Wittinghofer, Alfred

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Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes von Sot, Begoña, Behrmann, Elmar, Raunser, Stefan, Wittinghofer, Alfred

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A restricted spectrum of NRAS mutations causes Noonan syndrome von Gelb, Bruce D, Gremer, Lothar, Digilio, Cristina, Dentici, Maria L, Roberts, Amy E, Zampino, Giuseppe, Kratz, Christian P, Dallapiccola, Bruno, Mazzanti, Laura, Stuppia, Liborio, Pantaleoni, Francesca, Ahmadian, Mohammad R, Zenker, Martin, Lepri, Francesca, Kutsche, Kerstin, Silengo, Margherita Cirillo, Joshi, Victoria A, König, Rainer, Carta, Claudio, Horn, Denise, Merbitz-Zahradnik, Torsten, Pennacchio, Len A, Mundlos, Stefan, Tartaglia, Marco, Dvorsky, Radovan, Wittinghofer, Alfred, Cirstea, Ion C, Seemanova, Eva, Patton, Michael A, Rossi, Cesare, Kucherlapati, Raju S

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Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations von Gilsbach, Bernd K, Ho, Franz Y, Vetter, Ingrid R, van Haastert, Peter J. M, Wittinghofer, Alfred, Kortholt, Arjan

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