High fat diet causes distinct aberrations in the testicular proteome von Jarvis, S., Gethings, L. A., Samanta, L., Pedroni, S. M. A., Withers, D. J., Gray, N., Plumb, R. S., Winston, R. M. L., Williamson, C., Bevan, C. L.

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Disruption of IRS-2 causes type 2 diabetes in mice von White, Morris F, Withers, Dominic J, Gutierrez, Julio Sanchez, Towery, Heather, Burks, Deborah J, Ren, Jian-Ming, Previs, Stephen, Zhang, Yitao, Bernal, Dolores, Pons, Sebastian, Shulman, Gerald I, Bonner-Weir, Susan

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Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice von Cantley, J, Choudhury, A. I, Asare-Anane, H, Selman, C, Lingard, S, Heffron, H, Herrera, P, Persaud, S. J, Withers, D. J

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Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling von White, Morris F, Withers, Dominic J, Burks, Deborah J, Towery, Heather H, Altamuro, Shari L, Flint, Carrie L

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Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes von Withers, D J, White, M

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Sex and Death: What Is the Connection? von Partridge, Linda, Gems, David, Withers, Dominic J.

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hypoxia response pathway and β-cell function von Cantley, J, Grey, S.T, Maxwell, P.H, Withers, D.J

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5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus von Hisadome, K, Smith, M.A, Choudhury, A.I, Claret, M, Withers, D.J, Ashford, M.L.J

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Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice von Kulkarni, R N, Wang, Z L, Wang, R M, Hurley, J D, Smith, D M, Ghatei, M A, Withers, D J, Gardiner, J V, Bailey, C J, Bloom, S R

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Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice von Simmgen, M, Knauf, C, Lopez, M, Choudhury, A. I, Charalambous, M, Cantley, J, Bedford, D. C, Claret, M, Iglesias, M. A, Heffron, H, Cani, P. D, Vidal-Puig, A, Burcelin, R, Withers, D. J

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Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis von Wurster, Andrea L., Withers, Dominic J., Uchida, Tohru, White, Morris F., Grusby, Michael J.

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein tr... von Nave, B.T, Ouwens, D.M, Withers, D.J, Alessi, D.R, Shepherd, P.R

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling von Shepherd, P R, Withers, D J, Siddle, K

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IRS-2 pathways integrate female reproduction and energy homeostasis von White, Morris F, Burks, Deborah J, de Mora, Jaime Font, Schubert, Markus, Withers, Dominic J, Myers, Martin G, Towery, Heather H, Altamuro, Shari L, Flint, Carrie L

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Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice von Gelegen, C, Chandarana, K, Choudhury, A I, Al-Qassab, H, Evans, I M, Irvine, E E, Hyde, C B, Claret, M, Andreelli, F, Sloan, S E, Leiter, A B, Withers, D J, Batterham, R L

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Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo von Previs, Stephen F., Withers, Dominic J., Ren, Jian-Ming, White, Morris F., Shulman, Gerald I.

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Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle von Higaki, Yasuki, Wojtaszewski, Jørgen F.P., Hirshman, Michael F., Withers, Dominic J., Towery, Heather, White, Morris F., Goodyear, Laurie J.

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Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells von Withers, Dominic J., Coppock, Hedley A., Seufferlein, Thomas, Smith, David M., Bloom, Stephen R., Rozengurt, Enrique

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Longer Lifespan, Altered Metabolism, and Stress Resistance in Drosophila from Ablation of Cells Making Insulin-Like Ligands von Broughton, Susan J., Matthew D. W. Piper, Ikeya, Tomoatsu, Bass, Timothy M., Jacobson, Jake, Driege, Yasmine, Martinez, Pedro, Hafen, Ernst, Withers, Dominic J., Leevers, Sally J., Partridge, Linda, Kenyon, Cynthia J.

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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice von Killick, Richard, Scales, Georgie, Leroy, Karelle, Causevic, Mirsada, Hooper, Claudie, Irvine, Elaine E., Choudhury, Agharul I, Drinkwater, Laura, Kerr, Fiona, Al-Qassab, Hind, Stephenson, John, Yilmaz, Zehra, Giese, K. Peter, Brion, Jean-Pierre, Withers, Dominic J., Lovestone, Simon

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