Ghrelin octanoylation mediated by an orphan lipid transferase von Gutierrez, Jesus A, Solenberg, Patricia J, Perkins, Douglas R, Willency, Jill A, Knierman, Michael D, Jin, Zhaoyan, Witcher, Derrick R, Luo, Shuang, Onyia, Jude E, Hale, John E

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics von Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications von Theurl, Igor, Aigner, Elmar, Theurl, Milan, Nairz, Manfred, Seifert, Markus, Schroll, Andrea, Sonnweber, Thomas, Eberwein, Lukas, Witcher, Derrick R., Murphy, Anthony T., Wroblewski, Victor J., Wurz, Eva, Datz, Christian, Weiss, Guenter

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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB von Sonnweber, Thomas, Nachbaur, David, Schroll, Andrea, Nairz, Manfred, Seifert, Markus, Demetz, Egon, Haschka, David, Mitterstiller, Anna-Maria, Kleinsasser, Axel, Burtscher, Martin, Trübsbach, Susanne, Murphy, Anthony T, Wroblewski, Victor, Witcher, Derrick R, Mleczko-Sanecka, Katarzyna, Vecchi, Chiara, Muckenthaler, Martina U, Pietrangelo, Antonello, Theurl, Igor, Weiss, Günter

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Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies von Datta-Mannan, Amita, Estwick, Selina, Zhou, Chen, Choi, Hiuwan, Douglass, Nicole E, Witcher, Derrick R, Lu, Jirong, Beidler, Catherine, Millican, Rohn

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies von Datta-Mannan, Amita, Lu, Jirong, Witcher, Derrick R, Leung, Donmienne, Tang, Ying, Wroblewski, Victor J

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High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption von Sonnweber, Thomas, Ress, Claudia, Nairz, Manfred, Theurl, Igor, Schroll, Andrea, Murphy, Anthony T, Wroblewski, Victor, Witcher, Derrick R, Moser, Patrizia, Ebenbichler, Christoph F, Kaser, Susanne, Weiss, Günter

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Targeting the hepcidin–ferroportin pathway in anaemia of chronic kidney disease von Sheetz, Matthew, Barrington, Philip, Callies, Sophie, Berg, Paul H., McColm, Juliet, Marbury, Thomas, Decker, Brian, Dyas, Gregory L., Truhlar, Stephanie M.E., Benschop, Robert, Leung, Donmienne, Berg, Jolene, Witcher, Derrick R.

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Identification and Characterization of Nesfatin-1 Immunoreactivity in Endocrine Cell Types of the Rat Gastric Oxyntic Mucosa von Stengel, Andreas, Goebel, Miriam, Yakubov, Iskandar, Wang, Lixin, Witcher, Derrick, Coskun, Tamer, Taché, Yvette, Sachs, George, Lambrecht, Nils W. G

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Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry von Murphy, Anthony T., Witcher, Derrick R., Luan, Peng, Wroblewski, Victor J.

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Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR von Datta-Mannan, Amita, Witcher, Derrick R, Tang, Ying, Watkins, Jeffry, Wroblewski, Victor J

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Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway von Kelly, Ronan M., Kowle, Ronald L., Lian, Zhirui, Strifler, Beth A., Witcher, Derrick R., Parekh, Bhavin S., Wang, Tongtong, Frye, Christopher C.

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FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys von Datta-Mannan, Amita, Chow, Chi-Kin, Dickinson, Craig, Driver, David, Lu, Jirong, Witcher, Derrick R., Wroblewski, Victor J.

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Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men von Liu, Jianhua, Prudom, Catherine E., Nass, Ralf, Pezzoli, Suzan S., Oliveri, Mary C., Johnson, Michael L., Veldhuis, Paula, Gordon, David A., Howard, Andrew D., Witcher, Derrick R., Geysen, H. Mario, Gaylinn, Bruce D., Thorner, Michael O.

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Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells von Goebl, Nancy A, Babbey, Clifford M, Datta-Mannan, Amita, Witcher, Derrick R, Wroblewski, Victor J, Dunn, Kenneth W

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Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats von Theurl, Milan, Nairz, Manfred, Schroll, Andrea, Sonnweber, Thomas, Asshoff, Malte, Haschka, David, Seifert, Markus, Willenbacher, Wolfgang, Wilflingseder, Doris, Posch, Wilfried, Murphy, Anthony T, Witcher, Derrick R, Theurl, Igor, Weiss, Günter

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Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys von Datta-Mannan, Amita, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

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Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody von Boyles, Jeffrey S, Beidler, Catherine B, Strifler, Beth A, Girard, Daniel S, Druzina, Zhanna, Durbin, Jim D, Swearingen, Michelle L, Lee, Linda N, Kikly, Kristine, Chintharlapalli, Sudhakar, Witcher, Derrick R

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Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels von PICHLER, Irene, MINELLI, Cosetta, MASCHIO, Andrea, MELVILLE, Scott A, GRAZIA PIRAS, Maria, LONGO, Dan L, GURALNIK, Jack, HERNANDEZ, Dena, BANDINELLI, Stefania, AIGNER, Elmar, MURPHY, Anthony T, WROBLEWSKI, Victor, SANNA, Serena, MARRONI, Fabio, THEURL, Igor, GNEWUCH, Carsten, SCHADT, Eric, MITTERER, Manfred, SCHLESSINGER, David, FERRUCCI, Luigi, WITCHER, Derrick R, HICKS, Andrew A, WEISS, Günter, TANAKA, Toshiko, UDA, Manuela, PRAMSTALLER, Peter P, SCHWIENBACHER, Christine, NAITZA, Silvia, PORCU, Eleonora, PATTARO, Cristian, BUSONERO, Fabio, ZANON, Alessandra

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Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody von Boyles, Jeffrey S., Atwell, Shane, Druzina, Zhanna, Heuer, Josef G., Witcher, Derrick R.

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