Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress von Rainbolt, T. Kelly, Lebeau, Justine, Puchades, Cristina, Wiseman, R. Luke

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Small molecule strategies to harness the unfolded protein response: where do we go from here? von Grandjean, Julia M.D., Wiseman, R.Luke

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Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis von Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.

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Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy von Plate, Lars, Wiseman, R. Luke

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Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics von Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

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Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements von Yang, Jie, Song, Albert S., Wiseman, R. Luke, Lander, Gabriel C.

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Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing von Puchades, Cristina, Rampello, Anthony J., Shin, Mia, Giuliano, Christopher J., Wiseman, R. Luke, Glynn, Steven E., Lander, Gabriel C.

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Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation von Rainbolt, T. Kelly, Atanassova, Neli, Genereux, Joseph C., Wiseman, R. Luke

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Stress-responsive regulation of extracellular proteostasis von Mesgarzadeh, Jaleh S, Buxbaum, Joel N, Wiseman, R Luke

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Targeting protein aggregation for the treatment of degenerative diseases von Eisele, Yvonne S., Monteiro, Cecilia, Fearns, Colleen, Encalada, Sandra E., Wiseman, R. Luke, Powers, Evan T., Kelly, Jeffery W.

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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation von Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W

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The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress von Lebeau, Justine, Saunders, Jaclyn M., Moraes, Vivian W.R., Madhavan, Aparajita, Madrazo, Nicole, Anthony, Mary C., Wiseman, R. Luke

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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation von Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.

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Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease von Puchades, Cristina, Ding, Bojian, Song, Albert, Wiseman, R. Luke, Lander, Gabriel C., Glynn, Steven E.

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Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments von Shoulders, Matthew D., Ryno, Lisa M., Genereux, Joseph C., Moresco, James J., Tu, Patricia G., Wu, Chunlei, Yates, John R., Su, Andrew I., Kelly, Jeffery W., Wiseman, R. Luke

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Lining up for quality control: linear ubiquitin and proteotoxicity von Wiseman, R Luke

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Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity von Madhavan, Aparajita, Kok, Bernard P., Rius, Bibiana, Grandjean, Julia M. D., Alabi, Adekunle, Albert, Verena, Sukiasyan, Ara, Powers, Evan T., Galmozzi, Andrea, Saez, Enrique, Wiseman, R. Luke

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Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming von Grandjean, Julia M. D., Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O., Paxman, Ryan J., Smith, Emery, Scampavia, Louis, Powers, Evan T., Cooley, Christina B., Plate, Lars, Spicer, Timothy P., Kelly, Jeffery W., Wiseman, R. Luke

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PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress von Romine, Isabelle C., Wiseman, R. Luke

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PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid von Perea, Valerie, Cole, Christian, Lebeau, Justine, Dolina, Vivian, Baron, Kelsey R, Madhavan, Aparajita, Kelly, Jeffery W, Grotjahn, Danielle A, Wiseman, R Luke

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