PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow von Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors von Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David

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Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation von Guo, Jun, Lam, Lloyd T., Longenecker, Kenton L., Bui, Mai H., Idler, Kenneth B., Glaser, Keith B., Wilsbacher, Julie L., Tse, Chris, Pappano, William N., Huang, Tzu-Hsuan

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ERK2 Enters the Nucleus by a Carrier-Independent Mechanism von Whitehurst, Angelique W., Wilsbacher, Julie L., You, Youngjai, Luby-Phelps, Kate, Moore, Mary Shannon, Cobb, Melanie H.

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Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models von Stolzenburg, Lindsay R, Ainsworth, Barrett, Riley-Gillis, Bridget, Pakozdi, Tibor, Ammar, Areej, Ellis, Paul A, Wilsbacher, Julie L, Ramathal, Cyril Y

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Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation von Wilsbacher, Julie L., Zhang, Qian, Tucker, Lora A., Hubbard, Robert D., Sheppard, George S., Bamaung, Nwe Y., Fidanze, Steve D., Wang, Gary T., Hu, Xiaoming, Davidsen, Steven K., Bell, Randy L., Wang, Jieyi

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Characterization of Mitogen-Activated Protein Kinase (MAPK) Dimers von Wilsbacher, Julie L, Juang, Yu-Chi, Khokhlatchev, Andrei V, Gallagher, Ewen, Binns, Derk, Goldsmith, Elizabeth J, Cobb, Melanie H

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Requirements for Vav Guanine Nucleotide Exchange Factors and Rho GTPases in FcγR- and Complement-Mediated Phagocytosis von Hall, Amy B., Gakidis, M. Angelica Martinez, Glogauer, Michael, Wilsbacher, Julie L., Gao, Sizhen, Swat, Wojciech, Brugge, Joan S.

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WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II von Xu, Bing-e, English, Jessie M., Wilsbacher, Julie L., Stippec, Steve, Goldsmith, Elizabeth J., Cobb, Melanie H.

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Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors von Wilsbacher, Julie L, Cheng, Min, Cheng, Dong, Trammell, Samuel A J, Shi, Yan, Guo, Jun, Koeniger, Stormy L, Kovar, Peter J, He, Yupeng, Selvaraju, Sujatha, Heyman, H Robin, Sorensen, Bryan K, Clark, Richard F, Hansen, T Matthew, Longenecker, Kenton L, Raich, Diana, Korepanova, Alla V, Cepa, Steven, Towne, Danli L, Abraham, Vivek C, Tang, Hua, Richardson, Paul L, McLoughlin, Shaun M, Badagnani, Ilaria, Curtin, Michael L, Michaelides, Michael R, Maag, David, Buchanan, F Gregory, Chiang, Gary G, Gao, Wenqing, Rosenberg, Saul H, Brenner, Charles, Tse, Chris

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Advances towards the Development of ATP-Competitive Small-Molecule Inhibitors of the Insulin-Like Growth Factor Receptor (IGF-IR) von Hubbard, Robert D., Wilsbacher, Julie L.

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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) von Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

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Vav GEFs are required for β2 integrin-dependent functions of neutrophils von Gakidis, M. Angelica Martinez, Cullere, Xavier, Olson, Timothy, Wilsbacher, Julie L., Zhang, Bin, Moores, Sheri L., Ley, Klaus, Swat, Wojciech, Mayadas, Tanya, Brugge, Joan S.

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Controlling cellular distribution of drugs with permeability modifying moieties von Richardson, Paul L, Marin, Violeta L, Koeniger, Stormy L, Baranczak, Aleksandra, Wilsbacher, Julie L, Kovar, Peter J, Bacon-Trusk, Patricia E, Cheng, Min, Hopkins, Todd A, Haman, Sandra T, Vasudevan, Anil

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An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand von Wilsbacher, Julie L, Moores, Sheri L, Brugge, Joan S

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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases von Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.

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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases von WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J

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The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo von Xu, B e, Wilsbacher, J L, Collisson, T, Cobb, M H

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Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases von HUBBARD, Robert D, BAMAUNG, Nwe Y, OSTERLING, Donald J, JOHNSON, Eric F, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, FIDANZE, Steve D, ERICKSON, Scott A, PALAZZO, Fabio, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora A, XIAOMING HU, KOVAR, Peter

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Pyrazolo[3,4- d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR) von Hubbard, Robert D., Bamaung, Nwe Y., Palazzo, Fabio, Zhang, Qian, Kovar, Peter, Osterling, Donald J., Hu, Xiaoming, Wilsbacher, Julie L., Johnson, Eric F., Bouska, Jennifer, Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.

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