Progress towards a public chemogenomic set for protein kinases and a call for contributions von Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M

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Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans von Smith, Susan H., Jayawickreme, Channa, Rickard, David J., Nicodeme, Edwige, Bui, Thi, Simmons, Cathy, Coquery, Christine M., Neil, Jessica, Pryor, William M., Mayhew, David, Rajpal, Deepak K., Creech, Katrina, Furst, Sylvia, Lee, James, Wu, Dalei, Rastinejad, Fraydoon, Willson, Timothy M., Viviani, Fabrice, Morris, David C., Moore, John T., Cote-Sierra, Javier

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Quantifying CDK inhibitor selectivity in live cells von Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.

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Too many roads not taken von Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice von Zhang, Y, Lee, F.Y, Barrera, G, Lee, H, Vales, C, Gonzalez, F.J, Willson, T.M, Edwards, P.A

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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation von Pariollaud, Marie, Gibbs, Julie E, Hopwood, Thomas W, Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D Heulyn, Tellam, James P, Bresciani, Stefano, Tomkinson, Nicholas Co, Wojno-Picon, Justyna, Cooper, Anthony Wj, Daniels, Dion A, Trump, Ryan P, Grant, Daniel, Zuercher, William, Willson, Timothy M, MacDonald, Andrew S, Bolognese, Brian, Podolin, Patricia L, Sanchez, Yolanda, Loudon, Andrew Si, Ray, David W

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Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B von Chen, Peiling, Chaikuad, Apirat, Bamborough, Paul, Bantscheff, Marcus, Bountra, Chas, Chung, Chun-wa, Fedorov, Oleg, Grandi, Paola, Jung, David, Lesniak, Robert, Lindon, Matthew, Müller, Susanne, Philpott, Martin, Prinjha, Rab, Rogers, Catherine, Selenski, Carolyn, Tallant, Cynthia, Werner, Thilo, Willson, Timothy M, Knapp, Stefan, Drewry, David H

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The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism von Kliewer, Steven A, Goodwin, Bryan, Willson, Timothy M

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Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds von Korshunova, Maria, Huang, Niles, Capuzzi, Stephen, Radchenko, Dmytro S., Savych, Olena, Moroz, Yuriy S., Wells, Carrow I., Willson, Timothy M., Tropsha, Alexander, Isayev, Olexandr

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells von Yang, Xuan, Smith, Jeffery L, Beck, Michael T, Wilkinson, Jennifer M, Michaud, Ani, Vasta, James D, Robers, Matthew B, Willson, Timothy M

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A data science roadmap for open science organizations engaged in early-stage drug discovery von Edfeldt, Kristina, Edwards, Aled M., Engkvist, Ola, Günther, Judith, Hartley, Matthew, Hulcoop, David G., Leach, Andrew R., Marsden, Brian D., Menge, Amelie, Misquitta, Leonie, Müller, Susanne, Owen, Dafydd R., Schütt, Kristof T., Skelton, Nicholas, Steffen, Andreas, Tropsha, Alexander, Vernet, Erik, Wang, Yanli, Wellnitz, James, Willson, Timothy M., Clevert, Djork-Arné, Haibe-Kains, Benjamin, Schiavone, Lovisa Holmberg, Schapira, Matthieu

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STOPLIGHT: A Hit Scoring Calculator von Wellnitz, James, Martin, Holli-Joi, Anwar Hossain, Mohammad, Rath, Marielle, Fox, Colton, Popov, Konstantin I., Willson, Timothy M., Muratov, Eugene N., Tropsha, Alexander

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Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline von Nandakumar, Meganathan, Ollodart, Anja, Fleck, Neil, Kapadia, Nirav R., Frando, Andrew, Boradia, Vishant, Smith, Jeffery L., Chen, Junxi, Zuercher, William J., Willson, Timothy M., Grundner, Christoph

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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) von Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J

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ApoE Promotes the Proteolytic Degradation of Aβ von Jiang, Qingguang, Lee, C.Y. Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce, Willson, Timothy M., Collins, Jon L., Richardson, Jill C., Smith, Jonathan D., Comery, Thomas A., Riddell, David, Holtzman, David M., Tontonoz, Peter, Landreth, Gary E.

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Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3 von Galal, Kareem A., Krämer, Andreas, Strickland, Benjamin G., Smith, Jeffery L., Dickmander, Rebekah J., Moorman, Nathaniel J., Willson, Timothy M.

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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors von Asquith, Christopher R M, Godoi, Paulo H, Couñago, Rafael M, Laitinen, Tuomo, Scott, John W, Langendorf, Christopher G, Oakhill, Jonathan S, Drewry, David H, Zuercher, William J, Koutentis, Panayiotis A, Willson, Timothy M, Kalogirou, Andreas S

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ von Fong, Amy L, Ogawa, Sumito, Willson, Timothy M, Rosenfeld, Michael G, Perissi, Valentina, Pascual, Gabriel, Rose, David W, Li, Andrew C, Glass, Christopher K, Gamliel, Amir

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Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor von Zhang, Cunyu, Creech, Katrina L., Zuercher, William J., Willson, Timothy M.

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Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2 von Ong, Han Wee, Yang, Xuan, Smith, Jeffery L, Taft-Benz, Sharon, Howell, Stefanie, Dickmander, Rebekah J, Havener, Tammy M, Sanders, Marcia K, Brown, Jason W, Couñago, Rafael M, Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J, Heise, Mark, Axtman, Alison D, Drewry, David H, Willson, Timothy M

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