Life in the balance: how BH3-only proteins induce apoptosis von Willis, Simon N, Adams, Jerry M

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New players in the gene regulatory network controlling late B cell differentiation von Willis, Simon N, Nutt, Stephen L

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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB von Willis, Simon N., Tellier, Julie, Liao, Yang, Trezise, Stephanie, Light, Amanda, O’Donnell, Kristy, Garrett-Sinha, Lee Ann, Shi, Wei, Tarlinton, David M., Nutt, Stephen L.

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IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos von Fedele, Pasquale L., Willis, Simon N., Liao, Yang, Low, Michael S., Rautela, Jai, Segal, David H., Gong, Jia-Nan, Huntington, Nicholas D., Shi, Wei, Huang, David C.S., Grigoriadis, George, Tellier, Julie, Nutt, Stephen L.

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IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis von Low, Michael Sze Yuan, Brodie, Erica J., Fedele, Pasquale L., Liao, Yang, Grigoriadis, George, Strasser, Andreas, Kallies, Axel, Willis, Simon N., Tellier, Julie, Shi, Wei, Gabriel, Sarah, O’Donnell, Kristy, Pitt, Catherine, Nutt, Stephen L., Tarlinton, David

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized von van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.

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Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism von Willis, Simon N, Good-Jacobson, Kim L, Curtis, Joan, Light, Amanda, Tellier, Julie, Shi, Wei, Smyth, Gordon K, Tarlinton, David M, Belz, Gabrielle T, Corcoran, Lynn M, Kallies, Axel, Nutt, Stephen L

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An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway von Trezise, Stephanie, Kong, Isabella Y, Hawkins, Edwin D, Herold, Marco J, Willis, Simon N, Nutt, Stephen L

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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 von Puthalakath, Hamsa, Smyth, Mark J, Motoyama, Noboru, Strasser, Andreas, Huang, David C S, Dewson, Grant, Tarlinton, David M, Willis, Simon N, Tabarias, Hyacinth, Huntington, Nicholas D, Degli-Esposti, Mariapia A, Michalak, Ewa M, Nutt, Stephen L, Gunn, Priscilla, Naik, Edwina

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Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis von Ray, Arundhati, Amato, Anthony A, Bradshaw, Elizabeth M, Felice, Kevin J, DiCapua, Daniel B, Goldstein, Jonathan M, Lundberg, Ingrid E, Nowak, Richard J, Ploegh, Hidde L, Spooner, Eric, Wu, Qian, Willis, Simon N, O'Connor, Kevin C

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A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets von Almeida, Francisca F., Tognarelli, Sara, Marçais, Antoine, Kueh, Andrew J., Friede, Miriam E., Liao, Yang, Willis, Simon N., Luong, Kylie, Faure, Fabrice, Mercier, Francois E., Galluso, Justine, Firth, Matthew, Narni-Mancinelli, Emilie, Rais, Bushra, Scadden, David T., Spallotta, Francesco, Weil, Sandra, Giannattasio, Ariane, Kalensee, Franziska, Zöller, Tobias, Huntington, Nicholas D., Schleicher, Ulrike, Chiocchetti, Andreas G., Ugolini, Sophie, Herold, Marco J., Shi, Wei, Koch, Joachim, Steinle, Alexander, Vivier, Eric, Walzer, Thierry, Belz, Gabrielle T., Ullrich, Evelyn

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OBF1 and Oct factors control the germinal center transcriptional program von Song, Shuang, Cao, Chun, Choukrallah, Mohamed-Amin, Tang, Fengyuan, Christofori, Gerhard, Kohler, Hubertus, Wu, Fabian, Fodor, Barna D., Frederiksen, Mathias, Willis, Simon N., Jackson, Jacob T., Nutt, Stephen L., Dirnhofer, Stefan, Stadler, Michael B., Matthias, Patrick

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Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis von LOVATO, Laura, WILLIS, Simon N, RODIG, Scott J, CARON, Tyler, ALMENDINGER, Stefany E, HOWELL, Owain W, REYNOLDS, Richard, O'CONNOR, Kevin C, HAFLER, David A

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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak von Willis, Simon N, Fletcher, Jamie I, Kaufmann, Thomas, van Delft, Mark F, Chen, Lin, Czabotar, Peter E, Ierino, Helen, Lee, Erinna F, Fairlie, W. Douglas, Bouillet, Philippe, Strasser, Andreas, Kluck, Ruth M, Adams, Jerry M, Huang, David C.S

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The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function von Bergamasco, Maria I., Ranathunga, Nishika, Abeysekera, Waruni, Li-Wai-Suen, Connie S N, Garnham, Alexandra L., Willis, Simon N., McRae, Helen M., Yang, Yuqing, D’Amico, Angela, Di Rago, Ladina, Wilcox, Stephen, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim

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A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation von Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C. S., Fairlie, W. Douglas

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NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells von de Valle, Elisha, Grigoriadis, George, O'Reilly, Lorraine A, Willis, Simon N, Maxwell, Mhairi J, Corcoran, Lynn M, Tsantikos, Evelyn, Cornish, Jasper K S, Fairfax, Kirsten A, Vasanthakumar, Ajithkumar, Febbraio, Mark A, Hibbs, Margaret L, Pellegrini, Marc, Banerjee, Ashish, Hodgkin, Philip D, Kallies, Axel, Mackay, Fabienne, Strasser, Andreas, Gerondakis, Steve, Gugasyan, Raffi

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Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis von Querol, Luis, Clark, Pamela L., Bailey, Mary A., Cotsapas, Chris, Cross, Anne H., Hafler, David A., Kleinstein, Steven H., Lee, Jae-Yun, Yaari, Gur, Willis, Simon N., OʼConnor, Kevin C.

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The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response von Willis, Simon N, Mallozzi, Scott S, Rodig, Scott J, Cronk, Katherine M, McArdel, Shannon L, Caron, Tyler, Pinkus, Geraldine S, Lovato, Laura, Shampain, Kimberly L, Anderson, David E, Anderson, Richard C. E, Bruce, Jeffrey N, O'Connor, Kevin C

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CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers von Tarlinton, David M, Huntington, Nicholas D, Xu, Yuekang, Puthalakath, Hamsa, Light, Amanda, Willis, Simon N, Strasser, Andreas

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