Application of hepatocyte-like cells to enhance hepatic safety risk assessment in drug discovery von Williams, Dominic P.

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Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights von Lazic, Stanley E., Semenova, Elizaveta, Williams, Dominic P.

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Predicting Drug-Induced Liver Injury with Bayesian Machine Learning von Williams, Dominic P, Lazic, Stanley E, Foster, Alison J, Semenova, Elizaveta, Morgan, Paul

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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury von Proctor, William R., Foster, Alison J., Vogt, Jennifer, Summers, Claire, Middleton, Brian, Pilling, Mark A., Shienson, Daniel, Kijanska, Monika, Ströbel, Simon, Kelm, Jens M., Morgan, Paul, Messner, Simon, Williams, Dominic

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Reactive Metabolites: Current and Emerging Risk and Hazard Assessments von Thompson, Richard A, Isin, Emre M, Ogese, Monday O, Mettetal, Jerome T, Williams, Dominic P

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Managing the challenge of chemically reactive metabolites in drug development von Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A

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Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity von Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus

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Characterization of a functional C3A liver spheroid model von Gaskell, Harriet, Sharma, Parveen, Colley, Helen E, Murdoch, Craig, Williams, Dominic P, Webb, Steven D

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Introducing an automated high content confocal imaging approach for Organs-on-Chips von Peel, Samantha, Corrigan, Adam M, Ehrhardt, Beate, Jang, Kyung-Jin, Caetano-Pinto, Pedro, Boeckeler, Matthew, Rubins, Jonathan E, Kodella, Konstantia, Petropolis, Debora B, Ronxhi, Janey, Kulkarni, Gauri, Foster, Alison J, Williams, Dominic, Hamilton, Geraldine A, Ewart, Lorna

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Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury von Williams, C. David, Antoine, Daniel J., Shaw, Patrick J., Benson, Craig, Farhood, Anwar, Williams, Dominic P., Kanneganti, Thirumala-Devi, Park, B. Kevin, Jaeschke, Hartmut

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Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity von Antoine, Daniel J, Jenkins, Rosalind E, Dear, James W, Williams, Dominic P, McGill, Mitchell R, Sharpe, Matthew R, Craig, Darren G, Simpson, Kenneth J, Jaeschke, Hartmut, Park, B. Kevin

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A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function von Karageorgis, Anastassia, Lenhard, Stephen C, Yerby, Brittany, Forsgren, Mikael F, Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A, Peterson, Richard A, Yang, Xi, Williams, Dominic P, Ungersma, Sharon E, Morgan, Ryan E, Brouwer, Kim L R, Jucker, Beat M, Hockings, Paul D

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High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo von Antoine, Daniel J., Williams, Dominic P., Kipar, Anja, Jenkins, Rosalind E., Regan, Sophie L., Sathish, Jean G., Kitteringham, Neil R., Park, B. Kevin

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Leaf only SAM: A segment anything pipeline for zero-shot automated leaf segmentation von Williams, Dominic, Macfarlane, Fraser, Britten, Avril

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Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity von Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin

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The role of metabolic activation in drug-induced hepatotoxicity von PARK, B. Kevin, KITTERINGHAM, Neil R, MAGGS, James L, PIRMOHAMED, Munir, WILLIAMS, Dominic P

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Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid von Foster, Alison J., Chouhan, Bhavik, Regan, Sophie L., Rollison, Helen, Amberntsson, Sara, Andersson, Linda C., Srivastava, Abhishek, Darnell, Malin, Cairns, Jonathan, Lazic, Stanley E., Jang, Kyung-Jin, Petropolis, Debora B., Kodella, Konstantia, Rubins, Jonathan E., Williams, Dominic, Hamilton, Geraldine A., Ewart, Lorna, Morgan, Paul

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The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity von Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E., Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P., Kevin Park, B., Chadwick, Amy E.

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On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships von McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna

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Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity von Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin

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