Haplotyping germline and cancer genomes with high-throughput linked-read sequencing von Zheng, Grace X Y, Lau, Billy T, Schnall-Levin, Michael, Jarosz, Mirna, Bell, John M, Hindson, Christopher M, Kyriazopoulou-Panagiotopoulou, Sofia, Masquelier, Donald A, Merrill, Landon, Terry, Jessica M, Mudivarti, Patrice A, Wyatt, Paul W, Bharadwaj, Rajiv, Makarewicz, Anthony J, Li, Yuan, Belgrader, Phillip, Price, Andrew D, Lowe, Adam J, Marks, Patrick, Vurens, Gerard M, Hardenbol, Paul, Montesclaros, Luz, Luo, Melissa, Greenfield, Lawrence, Wong, Alexander, Birch, David E, Short, Steven W, Bjornson, Keith P, Patel, Pranav, Hopmans, Erik S, Wood, Christina, Kaur, Sukhvinder, Lockwood, Glenn K, Stafford, David, Delaney, Joshua P, Wu, Indira, Ordonez, Heather S, Grimes, Susan M, Greer, Stephanie, Lee, Josephine Y, Belhocine, Kamila, Giorda, Kristina M, Heaton, William H, McDermott, Geoffrey P, Bent, Zachary W, Meschi, Francesca, Kondov, Nikola O, Wilson, Ryan, Bernate, Jorge A, Gauby, Shawn, Kindwall, Alex, Bermejo, Clara, Fehr, Adrian N, Chan, Adrian, Saxonov, Serge, Ness, Kevin D, Hindson, Benjamin J, Ji, Hanlee P

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Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion von Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.

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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

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Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway von Tanwar, Vineeta, Bylund, Jeffery B., Hu, Jianyong, Yan, Jingbo, Walthall, Joel M., Mukherjee, Amrita, Heaton, William H., Wang, Wen‐Der, Potet, Franck, Rai, Meena, Kupershmidt, Sabina, Knapik, Ela W., Hatzopoulos, Antonis K.

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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer von Shouksmith, Andrew E, Shah, Fenil, Grimard, Michelle L, Gawel, Justyna M, Raouf, Yasir S, Geletu, Mulu, Berger-Becvar, Angelika, de Araujo, Elvin D, Luchman, H. Artee, Heaton, William L, Bakhshinyan, David, Adile, Ashley A, Venugopal, Chitra, O’Hare, Thomas, Deininger, Michael W, Singh, Sheila K, Konieczny, Stephen F, Weiss, Samuel, Fishel, Melissa L, Gunning, Patrick T

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shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance von Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O'Hare, Thomas, Deininger, Michael W.

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Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis von Yan, Dongqing, Pomicter, Anthony D, Tantravahi, Srinivas, Mason, Clinton C, Senina, Anna V, Ahmann, Jonathan M, Wang, Qiang, Than, Hein, Patel, Ami B, Heaton, William L, Eiring, Anna M, Clair, Phillip M, Gantz, Kevin C, Redwine, Hannah M, Swierczek, Sabina I, Halverson, Brayden J, Baloglu, Erkan, Shacham, Sharon, Khorashad, Jamshid S, Kelley, Todd W, Salama, Mohamed E, Miles, Rodney R, Boucher, Kenneth M, Prchal, Josef T, O'Hare, Thomas, Deininger, Michael W

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Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells von Than, Hein, Pomicter, Anthony D., Yan, Dongqing, Beaver, Larry P., Eiring, Anna M., Heaton, William L., Senina, Anna, Clair, Phillip M., Shacham, Sharon, Mason, Clinton C., Hare, Thomas O’, Deininger, Michael W.

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Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the Signaling Pathway von Tanwar, Vineeta, Bylund, Jeffery B, Hu, Jianyong, Yan, Jingbo, Walthall, Joel M, Mukherjee, Amrita, Heaton, William H, Wang, Wen-Der, Potet, Franck, Rai, Meena, Kupershmidt, Sabina, Knapik, Ela W, Hatzopoulos, Antonis K

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BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia von Zabriskie, Matthew S., Eide, Christopher A., Tantravahi, Srinivas K., Vellore, Nadeem A., Estrada, Johanna, Nicolini, Franck E., Khoury, Hanna J., Larson, Richard A., Konopleva, Marina, Cortes, Jorge E., Kantarjian, Hagop, Jabbour, Elias J., Kornblau, Steven M., Lipton, Jeffrey H., Rea, Delphine, Stenke, Leif, Barbany, Gisela, Lange, Thoralf, Hernández-Boluda, Juan-Carlos, Ossenkoppele, Gert J., Press, Richard D., Chuah, Charles, Goldberg, Stuart L., Wetzler, Meir, Mahon, Francois-Xavier, Etienne, Gabriel, Baccarani, Michele, Soverini, Simona, Rosti, Gianantonio, Rousselot, Philippe, Friedman, Ran, Deininger, Marie, Reynolds, Kimberly R., Heaton, William L., Eiring, Anna M., Pomicter, Anthony D., Khorashad, Jamshid S., Kelley, Todd W., Baron, Riccardo, Druker, Brian J., Deininger, Michael W., O’Hare, Thomas

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Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

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Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells von Pomicter, Anthony D., Clair, Phillip M., Yan, Dongqing, Heaton, William L., Eiring, Anna M., Anderson, Michael B., Richards, Stephen M., Gililland, Jeremy, O’Hare, Thomas, Deininger, Michael W.

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Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development von Raboisson, Patrick, Breitholtz-Emanuelsson, Anna, Dahllöf, Henrik, Edwards, Louise, Heaton, William L., Isaac, Methvin, Jarvie, Keith, Kers, Annika, Minidis, Alexander B.E., Nordmark, Anna, Sheehan, Susan M., Slassi, Abdelmalik, Ström, Peter, Terelius, Ylva, Wensbo, David, Wilson, Julie M., Xin, Tao, McLeod, Donald A.

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Insurgency In The Modern World von O'Neill, Bard E

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3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis von SHCHERBAKOVA, Irina, BALANDRIN, Manuel F, FOX, John, GHATAK, Anjan, HEATON, William L, CONKLIN, Rebecca L

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Inside Cover: Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities (ChemMedC... von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

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Computational methods for single cell RNA and genome assembly resolution using genetic variation von Heaton, William

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The Milroy lectures on epidemic disease in England; the evidence of variability and of persistency of type von Hamer, William Heaton, 1862-1936

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Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones von Shcherbakova, Irina, Huang, Guangfei, Geoffroy, Otto J., Nair, Satheesh K., Swierczek, Krzysztof, Balandrin, Manuel F., Fox, John, Heaton, William L., Conklin, Rebecca L.

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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia von Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W

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