Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds von Kumar, Vijay, Boorman, Jacob, Greenlee, William J., Zeng, Ximin, Lin, Jun, van den Akker, Focco

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Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice von Sato, Tadatoshi, Andrade, Christian D Castro, Yoon, Sung-Hee, Zhao, Yingshe, Greenlee, William J, Weber, Patricia C, Viswanathan, Usha, Kulp, John, Brooks, Daniel J, Demay, Marie B, Bouxsein, Mary L, Mitlak, Bruce, Lanske, Beate, Wein, Marc N

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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzhe... von Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W

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Aryl Hydrocarbon Receptor Regulates Cell Cycle Progression in Human Breast Cancer Cells via a Functional Interaction with Cyclin-Dependent Kinase 4 von Barhoover, Melissa A, Hall, Julie M, Greenlee, William F, Thomas, Russell S

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Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury von Zhou, Hua-Lin, Hausladen, Alfred, Anand, Puneet, Rajavel, Malligarjunan, Stomberski, Colin T., Zhang, Rongli, Premont, Richard T., Greenlee, William J., van den Akker, Focco, Stamler, Jonathan S.

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Activation of the Aryl-Hydrocarbon Receptor Inhibits Invasive and Metastatic Features of Human Breast Cancer Cells and Promotes Breast Cancer Cell Differentiation von Hall, Julie M, Barhoover, Melissa A, Kazmin, Dmitri, McDonnell, Donald P, Greenlee, William F, Thomas, Russell S

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Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity von Chackalamannil, Samuel, Wang, Yuguang, Greenlee, William J, Hu, Zhiyong, Xia, Yan, Ahn, Ho-Sam, Boykow, George, Hsieh, Yunsheng, Palamanda, Jairam, Agans-Fantuzzi, Jacqueline, Kurowski, Stan, Graziano, Michael, Chintala, Madhu

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Epigenetics: Novel Therapeutics Targeting Epigenetics von Conway, Stuart J, Woster, Patrick M, Greenlee, William J, Georg, Gunda, Wang, Shaomeng

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Arthur A. Patchett Memorial Issue von Wyvratt, Matthew, Greenlee, William

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Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery von Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning

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Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor von Cumming, Jared N., Smith, Elizabeth M., Wang, Lingyan, Misiaszek, Jeffrey, Durkin, James, Pan, Jianping, Iserloh, Ulrich, Wu, Yusheng, Zhu, Zhaoning, Strickland, Corey, Voigt, Johannes, Chen, Xia, Kennedy, Matthew E., Kuvelkar, Reshma, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Czarniecki, Michael F., Greenlee, William J., McKittrick, Brian A., Parker, Eric M., Stamford, Andrew W.

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Discovery of hydroxy pyrimidine Factor IXa inhibitors von Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel

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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents von Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

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Potent, selective, and orally active adenosine A2A receptor antagonists : Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1 ,5-c]pyrimidines von NEUSTADT, Bernard R, JINSONG HAO, FOSTER, Carolyn, ARIK, Leyla, LACHOWICZ, Jean, NG, Kwokei, FENG, Kung-I, LINDO, Neil, GREENLEE, William J, STAMFORD, Andrew W, TULSHIAN, Deen, ONGINI, Ennio, HUNTER, John, MONOPOLI, Angela, BERTORELLI, Rosalia

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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia von Yang, Shu-Wei, Smotryski, Jennifer, McElroy, William T., Tan, Zheng, Ho, Ginny, Tulshian, Deen, Greenlee, William J., Guzzi, Mario, Zhang, Xiaoping, Mullins, Deborra, Xiao, Li, Hruza, Alan, Chan, Tze-Ming, Rindgen, Diane, Bleickardt, Carina, Hodgson, Robert

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Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death von Matsuyama, Mieko, Ortega, Joseph T., Fedorov, Yuri, Scott-McKean, Jonah, Muller-Greven, Jeannie, Buck, Matthias, Adams, Drew, Jastrzebska, Beata, Greenlee, William, Matsuyama, Shigemi

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Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes von Xia, Yan, Chackalamannil, Samuel, Greenlee, William J., Jayne, Charles, Neustadt, Bernard, Stamford, Andrew, Vaccaro, Henry, Xu, Xiaoying (Lucy), Baker, Hana, O’Neill, Kim, Woods, Morgan, Hawes, Brian, Kowalski, Tim

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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4 von McElroy, William T, Michael Seganish, W, Jason Herr, R, Harding, James, Yang, Jinhai, Yet, Larry, Komanduri, Venukrishnan, Prakash, Koraboina Chandra, Lavey, Brian, Tulshian, Deen, Greenlee, William J, Sondey, Christopher, Fischmann, Thierry O, Niu, Xiaoda

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Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation von Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N, Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D, Caldwell, John P, Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giuseppe, Zhang, Lili, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Cox, Kathleen, Orth, Peter, Buevich, Alexei, Voigt, Johannes, Wang, Hongwu, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Parker, Eric M, Stamford, Andrew W

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