TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 von Peng, Qisheng, Malhotra, Shikha, Torchia, James A, Kerr, William G, Coggeshall, K Mark, Humphrey, Mary Beth

Volltext

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis von Pedicone, Chiara, Fernandes, Sandra, Dungan, Otto M, Dormann, Shawn M, Viernes, Dennis R, Adhikari, Arijit A, Choi, Lydia B, De Jong, Ebbing P, Chisholm, John D, Kerr, William G

Volltext

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity von Pardoll, Drew, Yu, Hua, Kortylewski, Marcin, Kujawski, Maciej, Wang, Tianhong, Wei, Sheng, Zhang, Shumin, Pilon-Thomas, Shari, Niu, Guilian, Kay, Heidi, Mulé, James, Kerr, William G, Jove, Richard

Volltext

Structure-Activity Studies on Bis-Sulfonamide SHIP1 Activators von Meyer, Shea T, Fernandes, Sandra, Anderson, Robert E, Pacherille, Angela, Toms, Bonnie, Kerr, William G, Chisholm, John D

Volltext

Role of SHIP1 in cancer and mucosal inflammation von Fernandes, Sandra, Iyer, Sonia, Kerr, William G.

Volltext

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans von Blanco-Menéndez, Noelia, Del Fresno, Carlos, Fernandes, Sandra, Calvo, Enrique, Conde-Garrosa, Ruth, Kerr, William G, Sancho, David

Volltext

N1 -Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents von Fernandes, Sandra, Meyer, Shea T, Shah, Jigisha P, Adhikari, Arijit A, Kerr, William G, Chisholm, John D

Volltext

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves von Kerr, William G, Chisholm, John D

Volltext

Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells von Ye, Xujun, Zhang, Fengrui, Zhou, Li, Wei, Yadong, Zhang, Li, Wang, Lihui, Tang, Haiying, Chen, Zi, Kerr, William G., Zheng, Tao, Zhu, Zhou

Volltext

SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells von Brooks, Robert, Fuhler, Gwenny M, Iyer, Sonia, Smith, Michelle J, Park, Mi-Young, Paraiso, Kim H. T, Engelman, Robert W, Kerr, William G

Volltext

LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism von Sudan, Raki, Fernandes, Sandra, Srivastava, Neetu, Pedicone, Chiara, Meyer, Shea T, Chisholm, John D, Engelman, Robert W, Kerr, William G

Volltext

Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer von Fuhler, Gwenny M, Brooks, Robert, Toms, Bonnie, Iyer, Sonia, Gengo, Elizabeth A, Park, Mi-Young, Gumbleton, Matthew, Viernes, Dennis R, Chisholm, John D, Kerr, William G

Volltext

Analysis of SHIP1 expression and activity in Crohn's disease patients von Somasundaram, Rajesh, Fernandes, Sandra, Deuring, Jasper J, de Haar, Colin, Kuipers, Ernst J, Vogelaar, Lauran, Middleton, Frank A, van der Woude, C Janneke, Peppelenbosch, Maikel P, Kerr, William G, Fuhler, Gwenny M

Volltext

Inhibitor and activator: dual functions for SHIP in immunity and cancer von Kerr, William G.

Volltext

SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction von Fernandes, Sandra, Srivastava, Neetu, Sudan, Raki, Middleton, Frank A, Shergill, Amandeep K, Ryan, James C, Kerr, William G

Volltext

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation von Hoekstra, Elmer, Das, Asha M, Willemsen, Marcella, Swets, Marloes, Kuppen, Peter J K, van der Woude, Christien J, Bruno, Marco J, Shah, Jigisha P, Ten Hagen, Timo L M, Chisholm, John D, Kerr, William G, Peppelenbosch, Maikel P, Fuhler, Gwenny M

Volltext

Mouse natural killer cell development and maturation are differentially regulated by SHIP-1 von Banh, Cindy, Miah, S. M. Shahjahan, Kerr, William G., Brossay, Laurent

Volltext

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment von Fernandes, Sandra, Srivastava, Neetu, Pedicone, Chiara, Sudan, Raki, Luke, Elizabeth A., Dungan, Otto M., Pacherille, Angela, Meyer, Shea T., Dormann, Shawn, Schurmans, Stéphane, Chambers, Benedict J., Chisholm, John D., Kerr, William G.

Volltext

SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis von Tang, Haiying, Mao, Jingwei, Ye, Xujun, Zhang, Fengrui, Kerr, William G., Zheng, Tao, Zhu, Zhou

Volltext

SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice von Gumbleton, Matthew, Vivier, Eric, Kerr, William G

Volltext