An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation von Kumar, Sanjay, Matheny, Christopher J, Hoffman, Sandra J, Marquis, Robert W, Schultz, Maggie, Liang, Xiaoguang, Vasko, Janice A, Stroup, George B, Vaden, Vernal R, Haley, Hyking, Fox, John, DelMar, Eric G, Nemeth, Edward F, Lago, Amparo M, Callahan, James F, Bhatnagar, Pradip, Huffman, William F, Gowen, Maxine, Yi, Bingming, Danoff, Theodore M, Fitzpatrick, Lorraine A

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Novel ATP-Competitive Kinesin Spindle Protein Inhibitors von Parrish, Cynthia A, Adams, Nicholas D, Auger, Kurt R, Burgess, Joelle L, Carson, Jeffrey D, Chaudhari, Amita M, Copeland, Robert A, Diamond, Melody A, Donatelli, Carla A, Duffy, Kevin J, Faucette, Leo F, Finer, Jeffrey T, Huffman, William F, Hugger, Erin D, Jackson, Jeffrey R, Knight, Steven D, Luo, Lusong, Moore, Michael L, Newlander, Ken A, Ridgers, Lance H, Sakowicz, Roman, Shaw, Antony N, Sung, Chiu-Mei M, Sutton, David, Wood, Kenneth W, Zhang, Shu-Yun, Zimmerman, Michael N, Dhanak, Dashyant

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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK von Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F

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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents von PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S

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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) von Heerding, Dirk A, Chan, George, DeWolf, Walter E, Fosberry, Andrew P, Janson, Cheryl A, Jaworski, Deborah D, McManus, Edward, Miller, William H, Moore, Terrance D, Payne, David J, Qiu, Xiayang, Rittenhouse, Stephen F, Slater-Radosti, Courtney, Smith, Ward, Takata, Dennis T, Vaidya, Kalindi S, Yuan, Catherine C.K, Huffman, William F

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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI) von Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F

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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents von Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, DeWolf, Walter E, Keller, Paul M, Qiu, Xiayang, Janson, Cheryl A, Vaidya, Kalindi, Fosberry, Andrew P, Smyth, Martin G, Jaworski, Deborah D, Slater-Radosti, Courtney, Huffman, William F

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Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat von Lark, Michael W., Stroup, George B., Dodds, Robert A., Kapadia, Rasesh, Hoffman, Sandra J., Hwang, Shing Mei, James, Ian E., Lechowska, Beata, Liang, Xiaoguang, Rieman, David J., Salyers, Kevin L., Ward, Keith, Smith, Brian R., Miller, William H., Huffman, William F., Gowen, Maxine

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Discovery of Potent Nonpeptide Vitronectin Receptor (αVβ3) Antagonists von Keenan, Richard M, Miller, William H, Kwon, Chet, Ali, Fadia E, Callahan, James F, Calvo, Raul R, Hwang, Shing-Mei, Kopple, Kenneth D, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Yuan, Chuan-Kui, Huffman, William F

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A Check on Rational Drug Design: Crystal Structure of a Complex of Human Immunodeficiency Virus Type 1 Protease with a Novel .gamma.-Turn Mimetic Inhibitor von Hoog, Susan S, Zhao, Baoguang, Winborne, Evon, Fisher, Seth, Green, David W, DesJarlais, Renee L, Newlander, Kenneth A, Callahan, James F, Abdel-Meguid, Sherin S, Moore, Michael L, Huffman, William F

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Structure−Activity Relationships of Novel Hematoregulatory Peptides von Bhatnagar, Pradip K, Agner, Erik K, Alberts, Doreen, Arbo, Bente E, Callahan, James F, Cuthbertson, Allan S, Engelsen, Steinar J, Fjerdingstad, Hege, Hartmann, Michael, Heerding, Dirk, Hiebl, Johann, Huffman, William F, Hysben, Mette, King, Andrew G, Kremminger, Peter, Kwon, Chet, LoCastro, Steve, Løvhaug, Dagfinn, Pelus, Louis M, Petteway, Steve, Takata, Joanne S

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Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist von Miller, William H., Ku, Thomas W., Ali, Fadia E., Bondinell, William E., Calvo, Raul R., Davis, Larry D., Erhard, Karl F., Hall, Leon B., Huffman, William F., Keenan, Richard M., Kwon, Chet, Newlander, Kenneth A., Ross, Stephen T., Samanen, James M., Takata, Dennis T., Yuan, Chuan-Kui

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A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of .gamma.-turn mimetics into a model substrate von Newlander, Kenneth A, Callahan, James F, Moore, Michael L, Tomaszek, Thaddeus A, Huffman, William F

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Nuclear analogs of .beta.-lactam antibiotics. 2. The total synthesis of 8-oxo-4-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids von Bryan, D. Boles, Hall, Ralph F, Holden, Kenneth G, Huffman, William F, Gleason, John G

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Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore von Ku, Thomas W, Miller, William H, Bondinell, William E, Erhard, Karl F, Keenan, Richard M, Nichols, Andrew J, Peishoff, Catherine E, Samanen, James M, Wong, Angela S, Huffman, William F

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Development of a Pharmacophore Model for a Novel Hematoregulatory Peptide von Bhatnagar, Pradip K, Alberts, Doreen, Callahan, James F, Heerding, Dirk, Huffman, William F, King, Andrew G, LoCastro, Steve, Pelus, Louis M, Takata, Joanne S

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Nuclear analogs of .beta.-lactam antibiotics. 1. The total synthesis of a 7-oxo-1,3-diazabicyclo[3.2.0]heptane-2-carboxylic acid via a versatile monocyclic .beta.-lactam intermedia... von Huffman, William F, Holden, Kenneth G, Buckley, Thomas F, Gleason, John G, Wu, L

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Stereoselective synthesis of hydroazulenes from cyclodecadienols von Marshall, James A, Huffman, William F, Ruth, James A

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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists von Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F

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Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionali... von Heerding, Dirk A., Takata, Dennis T., Kwon, Chet, Huffman, William F., Samanen, James

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