Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence von Mazor, Yariv, Sachsenmeier, Kris F., Yang, Chunning, Hansen, Anna, Filderman, Jessica, Mulgrew, Kathy, Wu, Herren, Dall’Acqua, William F.

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A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults von ROBBIE, Gabriel J, CRISTE, Ryan, DALL'ACQUA, William F, JENSEN, Kathryn, PATEL, Nita K, LOSONSKY, Genevieve A, GRIFFIN, M. Pamela

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Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) von Dall'Acqua, William F., Kiener, Peter A., Wu, Herren

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms von Oganesyan, Vaheh, Damschroder, Melissa M., Cook, Kimberly E., Li, Qing, Gao, Changshou, Wu, Herren, Dall'Acqua, William F.

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Structural characterization of a human Fc fragment engineered for lack of effector functions von Oganesyan, Vaheh, Gao, Changshou, Shirinian, Lena, Wu, Herren, Dall'Acqua, William F.

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Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody von Peng, Li, Oganesyan, Vaheh, Wu, Herren, Dall'Acqua, William F, Damschroder, Melissa M

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MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function von Kolbeck, Roland, PhD, Kozhich, Alexander, PhD, Koike, Masamichi, PhD, Peng, Li, PhD, Andersson, Cecilia K., PhD, Damschroder, Melissa M., BA, Reed, Jennifer L., PhD, Woods, Robert, MS, Dall'Acqua, William W., PhD, Stephens, Geoffrey L., PhD, Erjefalt, Jonas S., PhD, Bjermer, Leif, MD, Humbles, Alison A., PhD, Gossage, David, MD, Wu, Herren, PhD, Kiener, Peter A., PhD, Spitalny, George L., PhD, Mackay, Charles R., PhD, Molfino, Nestor A., MD, Coyle, Anthony J., PhD

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pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling von Borrok, M. Jack, Wu, Yanli, Beyaz, Nurten, Yu, Xiang-Qing, Oganesyan, Vaheh, Dall'Acqua, William F., Tsui, Ping

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Insights into the molecular basis of a bispecific antibody's target selectivity von Mazor, Yariv, Hansen, Anna, Yang, Chunning, Chowdhury, Partha S, Wang, Jihong, Stephens, Geoffrey, Wu, Herren, Dall'Acqua, William F

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Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models von Allen, Kevin L, Cann, Jennifer, Zhao, Weiguang, Peterson, Norman, Lazzaro, Michelle, Zhong, Haihong, Wu, Herren, Dall'Acqua, William F, Borrok, M Jack, Damschroder, Melissa M, Tsui, Ping, Li, Qing

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Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension von Li, Qing, Barrett, Allison, Vijayakrishnan, Balakumar, Tiberghien, Arnaud, Beard, Rhiannon, Rickert, Keith W, Allen, Kevin L, Christie, R. Jim, Marelli, Marcello, Harper, Jay, Howard, Philip, Wu, Herren, Dall’Acqua, William F, Tsui, Ping, Gao, Changshou, Borrok, M. Jack

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An “Fc-Silenced” IgG1 Format With Extended Half-Life Designed for Improved Stability von Borrok, M. Jack, Mody, Neil, Lu, Xiaojun, Kuhn, Megan L., Wu, Herren, Dall'Acqua, William F., Tsui, Ping

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Mechanisms of Neutralization of a Human Anti-α-toxin Antibody von Oganesyan, Vaheh, Peng, Li, Damschroder, Melissa M., Cheng, Li, Sadowska, Agnieszka, Tkaczyk, Christine, Sellman, Bret R., Wu, Herren, Dall'Acqua, William F.

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Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action von Geoghegan, James C, Diedrich, Gundo, Lu, Xiaojun, Rosenthal, Kim, Sachsenmeier, Kris F, Wu, Herren, Dall'Acqua, William F, Damschroder, Melissa M

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Antibody Fragment F(ab′)2 Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention von Li, Qing, Peterson, Norman, Hanna, Richard N, Kuszpit, Kyle, White, Jason, Allen, Kevin L, Barnes, Arnita, Rickert, Keith W, Shan, Lu, Wu, Herren, Dall’Acqua, William F, Tsui, Ping, Borrok, M. Jack

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Target-Agnostic Identification of Functional Monoclonal Antibodies Against Klebsiella pneumoniae Multimeric MrkA Fimbrial Subunit von Wang, Qun, Chang, Chew-shun, Pennini, Meghan, Pelletier, Mark, Rajan, Saravanan, Zha, Jingying, Chen, Yan, Cvitkovic, Romana, Sadowska, Agnieszka, Thompson, Jenny Heidbrink, Lin, Hung Yu, Barnes, Arnita, Rickert, Keith, Wilson, Susan, Stover, C. Kendall, Dall'Acqua, William F., Chowdhury, Partha S., Xiao, Xiaodong

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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells von Dovedi, Simon J, Elder, Matthew J, Yang, Chunning, Sitnikova, Suzanne I, Irving, Lorraine, Hansen, Anna, Hair, James, Jones, Des C, Hasani, Sumati, Wang, Bo, Im, Seock-Ah, Tran, Ben, Subramaniam, Deepa S, Gainer, Shelby D, Vashisht, Kapil, Lewis, Arthur, Jin, Xiaofang, Kentner, Stacy, Mulgrew, Kathy, Wang, Yaya, Overstreet, Michael G, Dodgson, James, Wu, Yanli, Palazon, Asis, Morrow, Michelle, Rainey, Godfrey J, Browne, Gareth J, Neal, Frances, Murray, Thomas V, Toloczko, Aleksandra D, Dall'Acqua, William, Achour, Ikbel, Freeman, Daniel J, Wilkinson, Robert W, Mazor, Yariv

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Long-acting antibody ligand mimetics for HER4-selective agonism von Shan, Lu, Cook, Kimberly M., Haskins, Nantaporn, Omar, Bilal, Jiang, Yu, Garcia, Andrew, Koksal, Adem, Oganesyan, Vaheh, Rosenthal, Kim, Wu, Herren, Dall’Acqua, William F., Damschroder, Melissa M.

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Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs von Li, Qing, Chan, Chingshen, Peterson, Norman, Hanna, Richard N, Alfaro, Alex, Allen, Kevin L, Wu, Herren, Dall’Acqua, William F, Borrok, M. Jack, Santos, Jose Luis

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Molecular basis for the mechanism of action of an anti-TACE antibody von Peng, Li, Cook, Kimberly, Xu, Linda, Cheng, Li, Damschroder, Melissa, Gao, Changshou, Wu, Herren, Dall'Acqua, William F

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