Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses von Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

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Mechanism for Effective Lymphoid Cell and Tissue Loading Following Oral Administration of Nucleotide Prodrug GS-7340 von Babusis, Darius, Phan, Truc K, Lee, William A, Watkins, William J, Ray, Adrian S

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Targeting lipid biosynthesis pathways for hepatitis B virus cure von Hyrina, Anastasia, Burdette, Dara, Song, Zhijuan, Ramirez, Ricardo, Okesli-Armlovich, Ayse, Vijayakumar, Archana, Bates, Jamie, Trevaskis, James L, Fletcher, Simon P, Lee, William A, Holdorf, Meghan M

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Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulat... von LEE, William A, HE, Gong-Xin, EISENBERG, Eugene, CIHLAR, Tomas, SWAMINATHAN, Swami, MULATO, Andrew, CUNDY, Kenneth C

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Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase von Shih, I-Hung, Vliegen, Inge, Peng, Betty, Yang, Huiling, Hebner, Christy, Paeshuyse, Jan, Pürstinger, Gerhard, Fenaux, Martijn, Tian, Yang, Mabery, Eric, Qi, Xiaoping, Bahador, Gina, Paulson, Matthew, Lehman, Laura S, Bondy, Steven, Tse, Winston, Reiser, Hans, Lee, William A, Schmitz, Uli, Neyts, Johan, Zhong, Weidong

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Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors von GARCIA-LERMA, J. Gerardo, AUNG, Wutyi, YEN-CHIN LIN, Carol, HANSON, Debra L, KERSH, Ellen, PAU, Chou-Pong, RAY, Adrian S, ROONEY, James F, LEE, William A, HENEINE, Walid, CONG, Mian-Er, QI ZHENG, YOUNGPAIROJ, Ae S, MITCHELL, James, HOLDER, Angela, MARTIN, Amy, KUKLENYIK, Susan, WEI LUO

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GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma von Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys von Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina

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Tenofovir alafenamide fumarate von Lee, William A, Cheng, Andrew K

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GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papil... von WOLFGANG, Grushenka H. I, SHIBATA, Riri, ANDREI, Graciela, SNOECK, Robert, JIANYING WANG, RAY, Adrian S, WU, Sylvia, DOERRFLER, Edward, REISER, Hans, LEE, William A, BIRKUS, Gabriel, CHRISTENSEN, Neil D

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Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-in... von Markowitz, Martin, Zolopa, Andrew, Squires, Kathleen, Ruane, Peter, Coakley, Dion, Kearney, Brian, Zhong, Lijie, Wulfsohn, Michael, Miller, Michael D, Lee, William A

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Targeting lipid biosynthesis pathways for hepatitis B virus cure von Anastasia Hyrina, Dara Burdette, Zhijuan Song, Ricardo Ramirez, Ayse Okesli-Armlovich, Archana Vijayakumar, Jamie Bates, James L. Trevaskis, Simon P. Fletcher, William A. Lee, Meghan M. Holdorf

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Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring von Cihlar, Tomas, He, Gong-Xin, Liu, Xiaohong, Chen, James M., Hatada, Marcos, Swaminathan, Swami, McDermott, Martin J., Yang, Zheng-Yu, Mulato, Andrew S., Chen, Xiaowu, Leavitt, Stephanie A., Stray, Kirsten M., Lee, William A.

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Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication von KEITH, Kathy A, HITCHCOCK, Michael J. M, LEE, William A, HOLY, Antonin, KERN, Earl R

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Perspectives on the development of acyclic nucleotide analogs as antiviral drugs von Lee, William A., Martin, John C.

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Substituted imidazopyridines as potent inhibitors of HCV replication von Vliegen, Inge, Paeshuyse, Jan, De Burghgraeve, Tine, Lehman, Laura S, Paulson, Matthew, Shih, I-Hung, Mabery, Eric, Boddeker, Nina, De Clercq, Erik, Reiser, Hans, Oare, David, Lee, William A, Zhong, Weidong, Bondy, Steven, Pürstinger, Gerhard, Neyts, Johan

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Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs von CUNDY, K. C, SUEOKA, C, LYNCH, G. R, GRIFFIN, L, LEE, W. A, SHAW, J.-P

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Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys von Durand-Gasselin, Lucie, Van Rompay, Koen K. A, Vela, Jennifer E, Henne, Ilana N, Lee, William A, Rhodes, Gerry R, Ray, Adrian S

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Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency vir... von VAN ROMPAY, Koen K. A, KEARNEY, Brian P, SEXTON, Jonathan J, COLON, Roxana, LAWSON, Jonathan R, BLACKWOOD, Emily J, LEE, William A, BISCHOFBERGER, Norbert, MARTHAS, Marta L

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Glass Vials for Small Volume Parenterals: Influence of Drug and Manufacturing Processes on Glass Delamination von Ennis, Richard D., Pritchard, Ray, Nakamura, Carey, Coulon, Michael, Yang, Taiyin, Visor, Gary C., Lee, William A.

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