Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease von Wiegman, Coen H, Li, Feng, Ryffel, Bernhard, Togbe, Dieudonnée, Chung, Kian Fan

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Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease von Wiegman, Coen H., PhD, Michaeloudes, Charalambos, PhD, Haji, Gulammehdi, MD, Narang, Priyanka, PhD, Clarke, Colin J., MSc, Russell, Kirsty E., PhD, Bao, Wuping, MD, Pavlidis, Stelios, PhD, Barnes, Peter J., MD, Kanerva, Justin, MSc, Bittner, Anton, PhD, Rao, Navin, PhD, Murphy, Michael P., PhD, Kirkham, Paul A., PhD, Chung, Kian Fan, MD, Adcock, Ian M., PhD

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Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways von Li, Xiang, Michaeloudes, Charalambos, Zhang, Yuelin, Wiegman, Coen H., Adcock, Ian M., Lian, Qizhou, Mak, Judith C.W., Bhavsar, Pankaj K., Chung, Kian Fan

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Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease von Haji, Gulam, Wiegman, Coen H., Michaeloudes, Charalambos, Patel, Mehul S., Curtis, Katrina, Bhavsar, Pankaj, Polkey, Michael I., Adcock, Ian M., Chung, Kian Fan

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The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD von Russell, Kirsty E, Chung, Kian Fan, Clarke, Colin J, Durham, Andrew L, Mallia, Patrick, Footitt, Joseph, Johnston, Sebastian L, Barnes, Peter J, Hall, Simon R, Simpson, Karen D, Starkey, Malcolm R, Hansbro, Philip M, Adcock, Ian M, Wiegman, Coen H

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Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma von Rossios, Christos, PhD, Pavlidis, Stelios, PhD, Hoda, Uruj, MBBS, Kuo, Chih-Hsi, MBBS, Wiegman, Coen, PhD, Russell, Kirsty, PhD, Sun, Kai, PhD, Loza, Matthew J., PhD, Baribaud, Frederic, PhD, Durham, Andrew L., PhD, Ojo, Oluwaseun, PhD, Lutter, Rene, PhD, Rowe, Anthony, PhD, Bansal, Aruna, PhD, Auffray, Charles, PhD, Sousa, Ana, PhD, Corfield, Julie, MSc, Djukanovic, Ratko, MD, Guo, Yike, PhD, Sterk, Peter J., MD, Chung, Kian Fan, MD, Adcock, Ian M., PhD

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Pulmonary toxicity of instilled silver nanoparticles: influence of size, coating and rat strain von Seiffert, Joanna, Hussain, Farhana, Wiegman, Coen, Li, Feng, Bey, Leo, Baker, Warren, Porter, Alexandra, Ryan, Mary P, Chang, Yan, Gow, Andrew, Zhang, Junfeng, Zhu, Jie, Tetley, Terry D, Chung, Kian Fan

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Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction von Bradley, Sophie J., Wiegman, Coen H., Iglesias, Max Maza, Kong, Kok Choi, Butcher, Adrian J., Plouffe, Bianca, Goupil, Eugénie, Bourgognon, Julie-Myrtille, Macedo-Hatch, Timothy, LeGouill, Christian, Russell, Kirsty, Laporte, Stéphane A., König, Gabriele M., Kostenis, Evi, Bouvier, Michel, Chung, Kian Fan, Amrani, Yassine, Tobin, Andrew B.

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Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation von Michaudel, Chloé, Maillet, Isabelle, Fauconnier, Louis, Quesniaux, Valérie, Chung, Kian Fan, Wiegman, Coen, Peter, Daniel, Ryffel, Bernhard

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Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness von Zhang, Pengyu, Li, Feng, Wiegman, Coen H, Zhang, Min, Hong, Yan, Gong, Jicheng, Chang, Yan, Zhang, Junfeng Jim, Adcock, Ian, Chung, Kian Fan, Zhou, Xin

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IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema von Pinart, Mariona, Zhang, Min, Li, Feng, Hussain, Farhana, Zhu, Jie, Wiegman, Coen, Ryffel, Bernard, Chung, Kian Fan

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BET proteins are a key component of immunoglobulin gene expression von Shim, Jung Min, Lee, Jin S, Russell, Kirsty E, Wiegman, Coen H, Barnes, Peter J, Fear, David, Adcock, Ian M, Durham, Andrew L

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Hepatic VLDL Production in ob/ob Mice Is Not Stimulated by Massive De Novo Lipogenesis but Is Less Sensitive to the Suppressive Effects of Insulin von WIEGMAN, Coen H, BANDSMA, Robert H. J, OUWENS, Margriet, VAN DER SLUIJS, Fjodor H, HAVINGA, Rick, BOER, Theo, REIJNGOUD, Dirk-Jan, ROMIJN, Johannes A, KUIPERS, Folkert

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Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation von Benthem, Lambertus, Keizer, Klaasjan, Wiegman, Coen H, de Boer, Sietse F, Strubbe, Jan H, Steffens, Anton B, Kuipers, Folkert, Scheurink, Anton J. W

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Acute Inhibition of Glucose-6-Phosphate Translocator Activity Leads to Increased De Novo Lipogenesis and Development of Hepatic Steatosis Without Affecting VLDL Production in Rats von BANDSMA, Robert H. J, WIEGMAN, Coen H, HERLING, Andreas W, BURGER, Hans-Joerg, TER HARMSEL, Anke, MEIJER, Alfred J, ROMIJN, Johannes A, REIJNGOUD, Dirk-Jan, KUIPERS, Folkert

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Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study von Loza, Matthew J, Djukanovic, Ratko, Chung, Kian Fan, Horowitz, Daniel, Ma, Keying, Branigan, Patrick, Barnathan, Elliot S, Susulic, Vedrana S, Silkoff, Philip E, Sterk, Peter J, Baribaud, Frédéric

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Epigenetics of asthma von Durham, Andrew L., Wiegman, Coen, Adcock, Ian M.

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Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats von Chung, Kian Fan, Seiffert, Joanna, Chen, Shu, Theodorou, Ioannis G, Goode, Angela Erin, Leo, Bey Fen, McGilvery, Catriona M, Hussain, Farhana, Wiegman, Coen, Rossios, Christos, Zhu, Jie, Gong, Jicheng, Tariq, Farid, Yufit, Vladimir, Monteith, Alexander J, Hashimoto, Teruo, Skepper, Jeremy N, Ryan, Mary P, Zhang, Junfeng, Tetley, Teresa D, Porter, Alexandra E

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A computational framework for complex disease stratification from multiple large-scale datasets von De Meulder, Bertrand, Lefaudeux, Diane, Bansal, Aruna T, Mazein, Alexander, Chaiboonchoe, Amphun, Ahmed, Hassan, Balaur, Irina, Saqi, Mansoor, Pellet, Johann, Ballereau, Stéphane, Lemonnier, Nathanaël, Sun, Kai, Pandis, Ioannis, Yang, Xian, Batuwitage, Manohara, Kretsos, Kosmas, van Eyll, Jonathan, Bedding, Alun, Davison, Timothy, Dodson, Paul, Larminie, Christopher, Postle, Anthony, Corfield, Julie, Djukanovic, Ratko, Chung, Kian Fan, Adcock, Ian M, Guo, Yi-Ke, Sterk, Peter J, Manta, Alexander, Rowe, Anthony, Baribaud, Frédéric, Auffray, Charles

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Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the ch... von van Dijk, T H, van der Sluijs, F H, Wiegman, C H, Baller, J F, Gustafson, L A, Burger, H J, Herling, A W, Kuipers, F, Meijer, A J, Reijngoud, D J

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