Dual HER2 Targeting with Trastuzumab and Liposomal-Encapsulated Doxorubicin (MM-302) Demonstrates Synergistic Antitumor Activity in Breast and Gastric Cancer von Espelin, Christopher W, Leonard, Shannon C, Geretti, Elena, Wickham, Thomas J, Hendriks, Bart S

Volltext

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic von Zhang, Xuqing, Luo, Mengyao, Dastagir, Shamael R., Nixon, Mellissa, Khamhoung, Annie, Schmidt, Andrea, Lee, Albert, Subbiah, Naren, McLaughlin, Douglas C., Moore, Christopher L., Gribble, Mary, Bayhi, Nicholas, Amin, Viral, Pepi, Ryan, Pawar, Sneha, Lyford, Timothy J., Soman, Vikram, Mellen, Jennifer, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Chen, Tiffany F.

Volltext

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation st... von Munster, Pamela, Krop, Ian E., LoRusso, Patricia, Ma, Cynthia, Siegel, Barry A., Shields, Anthony F., Molnár, István, Wickham, Thomas J., Reynolds, Joseph, Campbell, Karen, Hendriks, Bart S., Adiwijaya, Bambang S., Geretti, Elena, Moyo, Victor, Miller, Kathy D.

Volltext

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve,... von Miller, Kathy, Cortes, Javier, Hurvitz, Sara A, Krop, Ian E, Tripathy, Debu, Verma, Sunil, Riahi, Kaveh, Reynolds, Joseph G, Wickham, Thomas J, Molnar, Istvan, Yardley, Denise A

Volltext

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302) von Geretti, Elena, Leonard, Shannon Curtis, Dumont, Nancy, Lee, Helen, Zheng, Jinzi, De Souza, Raquel, Gaddy, Daniel F, Espelin, Christopher W, Jaffray, David A, Moyo, Victor, Nielsen, Ulrik B, Wickham, Thomas J, Hendriks, Bart S

Volltext

Single-Cell Quantitative HER2 Measurement Identifies Heterogeneity and Distinct Subgroups within Traditionally Defined HER2-Positive Patients von Onsum, Matthew D, Geretti, Elena, Paragas, Violette, Kudla, Arthur J, Moulis, Sharon P, Luus, Lia, Wickham, Thomas J, McDonagh, Charlotte F, MacBeath, Gavin, Hendriks, Bart S

Volltext

Impact of tumor HER2/ERBB2 expression level on HER2-targeted liposomal doxorubicin-mediated drug delivery: multiple low-affinity interactions lead to a threshold effect von Hendriks, Bart S, Klinz, Stephan G, Reynolds, Joseph G, Espelin, Christopher W, Gaddy, Daniel F, Wickham, Thomas J

Volltext

Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15 von McArdel, Shannon L., Dugast, Anne-Sophie, Hoover, Maegan E., Bollampalli, Arjun, Hong, Enping, Castano, Zafira, Leonard, Shannon Curtis, Pawar, Sneha, Mellen, Jennifer, Muriuki, Kelvin, McLaughlin, Douglas C., Bayhi, Nicholas, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Elloul, Sivan

Volltext

Nanoliposome targeting in breast cancer is influenced by the tumor microenvironment von Dumont, Nancy, Merrigan, Samantha, Turpin, Jason, Lavoie, Cynthia, Papavasiliou, Vasilios, Geretti, Elena, Espelin, Christopher W., Luus, Lia, Kamoun, Walid S., Ghasemi, Omid, Sahagian, G. Gary, Muller, William J., Hendriks, Bart S., Wickham, Thomas J., Drummond, Daryl C.

Volltext

Ligand-directed targeting of genes to the site of disease von Wickham, Thomas J

Volltext

HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity von Reynolds, Joseph G., Geretti, Elena, Hendriks, Bart S., Lee, Helen, Leonard, Shannon C., Klinz, Stephan G., Noble, Charles O., Lücker, Petra B., Zandstra, Peter W., Drummond, Daryl C., Olivier, Kenneth J., Nielsen, Ulrik B., Niyikiza, Clet, Agresta, Samuel V., Wickham, Thomas J.

Volltext

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastati... von Lee, Helen, Shields, Anthony F., Siegel, Barry A., Miller, Kathy D., Krop, Ian, Ma, Cynthia X., LoRusso, Patricia M., Munster, Pamela N., Campbell, Karen, Gaddy, Daniel F., Leonard, Shannon C., Geretti, Elena, Blocker, Stephanie J., Kirpotin, Dmitri B., Moyo, Victor, Wickham, Thomas J., Hendriks, Bart S.

Volltext

Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae von Roelvink, Peter W., Lee, Gai Mi, Einfeld, David A., Kovesdi, Imre, Wickham, Thomas J.

Volltext

GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes von Uenishi, Gene I, Repic, Marko, Yam, Jennifer Y, Landuyt, Ashley, Saikumar-Lakshmi, Priya, Guo, Tingxi, Zarin, Payam, Sassone-Corsi, Martina, Chicoine, Adam, Kellogg, Hunter, Hunt, Martina, Drow, Travis, Tewari, Ritika, Cook, Peter J, Yang, Soo Jung, Cerosaletti, Karen, Schweinoch, Darius, Guiastrennec, Benjamin, James, Eddie, Patel, Chandra, Chen, Tiffany F, Buckner, Jane H, Rawlings, David J, Wickham, Thomas J, Mueller, Karen T

Volltext

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors von QIANG LIU, ZAISS, Anne K, COLARUSSO, Pina, PATEL, Kamala, HALJAN, Gregory, WICKHAM, Thomas J, MURUVE, Daniel A

Volltext

Epitopes Expressed in Different Adenovirus Capsid Proteins Induce Different Levels of Epitope-Specific Immunity von KRAUSE, Anja, JOH, Ju H, HACKETT, Neil R, ROELVINK, Peter W, BRUDER, Joseph T, WICKHAM, Thomas J, KOVESDI, Imre, CRYSTAL, Ronald G, WORGALL, Stefan

Volltext

Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types von Wickham, Thomas J, Roelvink, Peter W, Brough, Douglas E, Kovesdi, Imre

Volltext

Companion Diagnostic 64Cu-Liposome Positron Emission Tomography Enables Characterization of Drug Delivery to Tumors and Predicts Response to Cancer Nanomedicines von Lee, Helen, Gaddy, Daniel, Ventura, Manuela, Bernards, Nicholas, de Souza, Raquel, Kirpotin, Dmitri, Wickham, Thomas, Fitzgerald, Jonathan, Zheng, Jinzi, Hendriks, Bart S

Volltext

144 RTX-240, an allogeneic engineered red blood cell expressing 4–1BBL and IL-15TP, promotes NK cell functionality in vitro and in vivo von Dugast, Anne-Sophie, McArdel, Shannon, Hong, Enping, Bollampalli, Arjun, Hoover, Maegan, Pawar, Sneha, Amin, Viral, Qiao, Kangjian, Ta, Christopher, Turka, Laurence, Wickham, Thomas, Elloul, Sivan

Volltext

Modification to the Capsid of the Adenovirus Vector That Enhances Dendritic Cell Infection and Transgene-Specific Cellular Immune Responses von WORGALL, Stefan, BUSCH, Annette, KOVESDI, Imi, CRYSTAL, Ronald G, RIVARA, Michael, BONNYAY, David, LEOPOLD, Philip L, MERRITT, Robert, HACKETT, Neil R, ROVELINK, Peter W, BRUDER, Joseph T, WICKHAM, Thomas J

Volltext