Potent and Selective Nonpeptidic Inhibitors of Procollagen C-Proteinase von Fish, Paul V, Allan, Gillian A, Bailey, Simon, Blagg, Julian, Butt, Richard, Collis, Michael G, Greiling, Doris, James, Kim, Kendall, Jackie, McElroy, Andrew, McCleverty, Dawn, Reed, Charlotte, Webster, Robert, Whitlock, Gavin A

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis von Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan

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Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space von Alex, Alexander, Millan, David S., Perez, Manuel, Wakenhut, Florian, Whitlock, Gavin A.

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Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition von Fish, Paul V., Deur, Christopher, Gan, Xinmin, Greene, Keri, Hoople, David, Mackenny, Malcolm, Para, Kimberly S., Reeves, Keith, Ryckmans, Thomas, Stiff, Cory, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.

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Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells von Ward, Jennifer A, McLellan, Lauren, Stockley, Martin, Gibson, Karl R, Whitlock, Gavin A, Knights, Charlotte, Harrigan, Jeanine A, Jacq, Xavier, Tate, Edward W

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Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity von Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J

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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lu... von Jones, Peter, Storer, R. Ian, Sabnis, Yogesh A, Wakenhut, Florian M, Whitlock, Gavin A, England, Katherine S, Mukaiyama, Takasuke, Dehnhardt, Christoph M, Coe, Jotham W, Kortum, Steve W, Chrencik, Jill E, Brown, David G, Jones, Rhys M, Murphy, John R, Yeoh, Thean, Morgan, Paul, Kilty, Iain

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Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5‑d]azepines as Potent 5‑Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivi... von Storer, R. Ian, Brennan, Paul E, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Corbett, Matthew S, DePianta, Robert P, Fish, Paul V, Heifetz, Alexander, Ho, Danny K. H, Jessiman, Alan S, McMurray, Gordon, de Oliveira, Cesar Augusto F, Roberts, Lee R, Root, James A, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A, Wright, John

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Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity von Musonda, Chitalu C., Whitlock, Gavin A., Witty, Michael J., Brun, Reto, Kaiser, Marcel

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Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity von Musonda, Chitalu C., Whitlock, Gavin A., Witty, Michael J., Brun, Reto, Kaiser, Marcel

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Identification of Type-II Inhibitors Using Kinase Structures von Lovering, Frank, McDonald, Joseph, Whitlock, Gavin A., Glossop, Paul A., Phillips, Chris, Bent, Andrew, Sabnis, Yogesh, Ryan, Mark, Fitz, Lori, Lee, Julie, Chang, Jeanne S., Han, Seungil, Kurumbail, Ravi, Thorarensen, Atli

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Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists von ROBERTS, Lee R, BRYANS, Justin, CONLON, Kelly, MCMURRAY, Gordon, STOBIE, Alan, WHITLOCK, Gavin A

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Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity von Whitlock, Gavin A., Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian

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1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity von Whitlock, Gavin A., Blagg, Julian, Fish, Paul V.

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Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks von Whitlock, Gavin A., Brennan, Paul E., Roberts, Lee R., Stobie, Alan

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4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships von Fish, Paul V., Andrews, Mark D., Jonathan Fray, M., Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.

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Discovery of a novel azepine series of potent and selective 5-HT2c agonists as potential treatments for urinary incontinence von BRENNAN, Paul E, WHITLOCK, Gavin A, HO, Danny K. H, CONLON, Kelly, MCMURRAY, Gordon

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A novel series of highly selective inhibitors of MMP-3 von Whitlock, Gavin A., Dack, Kevin N., Dickinson, Roger P., Lewis, Mark L.

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Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists von WHITLOCK, Gavin A, CONLON, Kelly, MCMURRAY, Gordon, ROBERTS, Lee R, STOBIE, Alan, THURLOW, Richard J

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N-Benzyl- N-(tetrahydro-2 H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors von Fish, Paul V., Fray, M. Jonathan, Stobie, Alan, Wakenhut, Florian, Whitlock, Gavin A.

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