Large-scale prediction and testing of drug activity on side-effect targets von Lounkine, Eugen, Keiser, Michael J., Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy L., Lavan, Paul, Weber, Eckhard, Doak, Allison K., Côté, Serge, Shoichet, Brian K., Urban, Laszlo

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Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development von Whitebread, Steven, Hamon, Jacques, Bojanic, Dejan, Urban, Laszlo

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Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty von Kramer, Christian, Fuchs, Julian E, Whitebread, Steven, Gedeck, Peter, Liedl, Klaus R

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Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets von Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Farmer, Pierre, DuMouchel, William, Shoichet, Brian K, Urban, Laszlo

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling von Bowes, Joanne, Brown, Andrew J., Hamon, Jacques, Jarolimek, Wolfgang, Sridhar, Arun, Waldron, Gareth, Whitebread, Steven

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ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies von Hintermann, Samuel, Vranesic, Ivo, Allgeier, Hans, Brülisauer, Armin, Hoyer, Daniel, Lemaire, Michel, Moenius, Thomas, Urwyler, Stephan, Whitebread, Steven, Gasparini, Fabrizio, Auberson, Yves P.

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In vitro safety pharmacology profiling : an essential tool for successful drug development von WHITEBREAD, Steven, HAMON, Jacques, BOJANIC, Dejan, URBAN, Laszlo

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The activities of drug inactive ingredients on biological targets von Pottel, Joshua, Armstrong, Duncan, Zou, Ling, Fekete, Alexander, Huang, Xi-Ping, Torosyan, Hayarpi, Bednarczyk, Dallas, Whitebread, Steven, Bhhatarai, Barun, Liang, Guiqing, Jin, Hong, Ghaemi, S. Nassir, Slocum, Samuel, Lukacs, Katalin V., Irwin, John J., Berg, Ellen L., Giacomini, Kathleen M., Roth, Bryan L., Shoichet, Brian K., Urban, Laszlo

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Secondary pharmacology: screening and interpretation of off-target activities – focus on translation von Whitebread, Steven, Dumotier, Berengere, Armstrong, Duncan, Fekete, Alexander, Chen, Shanni, Hartmann, Andreas, Muller, Patrick Y., Urban, Laszlo

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Preliminary biochemical characterization of two angiotensin II receptor subtypes von Whitebread, Steven, Mele, Michèle, Kamber, Bruno, de Gasparo, Marc

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Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1‐receptor subtype von Criscione, Leoluca, Gasparo, Marc, Bühlmayer, Peter, Whitebread, Steven, Ramjoué, Hans‐peter R., Wood, Jeanette

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Binding of valsartan to mammalian angiotensin AT1 receptors von DE GASPARO, M, WHITEBREAD, S

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Mapping Adverse Drug Reactions in Chemical Space von Scheiber, Josef, Jenkins, Jeremy L, Sukuru, Sai Chetan K, Bender, Andreas, Mikhailov, Dmitri, Milik, Mariusz, Azzaoui, Kamal, Whitebread, Steven, Hamon, Jacques, Urban, Laszlo, Glick, Meir, Davies, John W

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Inhibition of Bile Salt Export Pump (BSEP) in Relation to Systemic Exposure: A Risk Factor for Drug Induced Liver Injury (DILI) von Whitebread, Steven, Fekete, Alexander, Jin, Hong, Armstrong, Duncan, Urban, Laszlo

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Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 von Reck, Folkert, Bermingham, Alun, Blais, Johanne, Capka, Vladimir, Cariaga, Taryn, Casarez, Anthony, Colvin, Richard, Dean, Charles R., Fekete, Alex, Gong, Wanben, Growcott, Ellie, Guo, Hongqiu, Jones, Adriana K., Li, Cindy, Li, Fengxia, Lin, Xiaodong, Lindvall, Mika, Lopez, Sara, McKenney, David, Metzger, Louis, Moser, Heinz E., Prathapam, Ramadevi, Rasper, Dita, Rudewicz, Patrick, Sethuraman, Vijay, Shen, Xiaoyu, Shaul, Jacob, Simmons, Robert L., Tashiro, Kyuto, Tang, Dazhi, Tjandra, Meiliana, Turner, Nancy, Uehara, Tsuyoshi, Vitt, Charles, Whitebread, Steven, Yifru, Aregahegn, Zang, Xu, Zhu, Qingming

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Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data von Azzaoui, Kamal, Hamon, Jacques, Faller, Bernard, Whitebread, Steven, Jacoby, Edgar, Bender, Andreas, Jenkins, Jeremy L., Urban, Laszlo

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Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure von Bender, Andreas, Scheiber, Josef, Glick, Meir, Davies, John W., Azzaoui, Kamal, Hamon, Jacques, Urban, Laszlo, Whitebread, Steven, Jenkins, Jeremy L.

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Learning from approved kinase inhibitors to better inform on the safety risks of specific kinases von Vicart, Axel, Kinyamu-Akunda, Jacqueline, Whitebread, Steven, Dumotier, Berengere, Urban, Laszlo, Kluwe, William, Moggs, Jonathan, Pognan, François, Chibout, Salah-Dine

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Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis von Scheiber, Josef, Chen, Bin, Milik, Mariusz, Sukuru, Sai Chetan K, Bender, Andreas, Mikhailov, Dmitri, Whitebread, Steven, Hamon, Jacques, Azzaoui, Kamal, Urban, Laszlo, Glick, Meir, Davies, John W, Jenkins, Jeremy L

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A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products von Wassermann, Anne Mai, Lounkine, Eugen, Urban, Laszlo, Whitebread, Steven, Chen, Shanni, Hughes, Kevin, Guo, Hongqiu, Kutlina, Elena, Fekete, Alexander, Klumpp, Martin, Glick, Meir

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