Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target von Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria von Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

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Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage von Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Chatelain, Eric, Kelly, John M.

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An in vitro toolbox to accelerate anti-malarial drug discovery and development von Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada

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Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials von Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis C. K, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Crespo, Benigno, Sanz, Laura M, Wang, Binglin, Wittlin, Sergio, Charman, Susan A, Avery, Vicky M, Cho, Nobuo, Kamaura, Masahiro

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Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers von Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K

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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) von Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L

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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential von Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones von Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L, Shackleford, David M, O'Loughlin, Kathleen G, Charman, Susan A, Mirsalis, Jon C, Guy, R Kiplin

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Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease von BAHIA, Maria T, NASCIMENTO, Alvaro F. S, KOLTUN, Maria, SAUNDERS, Jessica, WHITE, Karen L, SCANDALE, Ivan, CHARMAN, Susan A, CHATELAIN, Eric, MAZZETI, Ana Lia, MARQUES, Luiz F, GONCALVES, Karolina R, MOTA, Ludmilla W. R, DINIZ, Lívia de F, CALDAS, Ivo S, TALVANI, André, SHACKLEFORD, David M

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Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp von Davis, Rohan A, Buchanan, Malcolm S, Duffy, Sandra, Avery, Vicky M, Charman, Susan A, Charman, William N, White, Karen L, Shackleford, David M, Edstein, Michael D, Andrews, Katherine T, Camp, David, Quinn, Ronald J

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1 von Le Manach, Claire, Gonzàlez Cabrera, Diego, Douelle, Frederic, Nchinda, Aloysius T, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, White, Karen L, Ryan, Eileen, March, Corinne, Duffy, Sandra, Avery, Vicky M, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Street, Leslie J, Chibale, Kelly

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Progress in antischistosomal N,N′-diaryl urea SAR von Wu, Jianbo, Wang, Chunkai, Leas, Derek, Vargas, Mireille, White, Karen L., Shackleford, David M., Chen, Gong, Sanford, Austin G., Hemsley, Ryan M., Davis, Paul H., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.

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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib von BUCKNER, Frederick S, TEREZINHA BAHIA, Maria, VERLINDE, Christophe L. M. J, CHARMAN, Susan A, LEPESHEVA, Galina I, GELBC, Michael H, KUMAR SURYADEVARA, Praveen, WHITE, Karen L, SHACKLEFORD, David M, KUMAR CHENNAMANENI, Naveen, HULVERSON, Matthew A, LAYDBAK, Joy U, CHATELAIN, Eric, SCANDALE, Ivan

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Inactivation of the Murine X-Linked Juvenile Retinoschisis Gene, Rs1h, Suggests a Role of Retinoschisin in Retinal Cell Layer Organization and Synaptic Structure von Bernhard H. F. Weber, Schrewe, Heinrich, Molday, Laurie L., Gehrig, Andrea, White, Karen L., Seeliger, Mathias W., Jaissle, Gesine B., Friedburg, Christoph, Tamm, Ernst, Molday, Robert S.

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Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells von White, Karen L., Rades, Thomas, Furneaux, Richard H., Tyler, Peter C., Hook, Sarah

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Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice von Gujjar, Ramesh, Marwaha, Alka, El Mazouni, Farah, White, John, White, Karen L, Creason, Sharon, Shackleford, David M, Baldwin, Jeffrey, Charman, William N, Buckner, Frederick S, Charman, Susan, Rathod, Pradipsinh K, Phillips, Margaret A

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Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials von Stoye, Alexander, Juillard, Annette, Tang, Arthur H, Legac, Jennifer, Gut, Jiri, White, Karen L, Charman, Susan A, Rosenthal, Philip J, Grau, Georges E. R, Hunt, Nicholas H, Payne, Richard J

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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate P... von Coteron, Jose M, Marco, María, Esquivias, Jorge, Deng, Xiaoyi, White, Karen L, White, John, Koltun, Maria, El Mazouni, Farah, Kokkonda, Sreekanth, Katneni, Kasiram, Bhamidipati, Ravi, Shackleford, David M, Angulo-Barturen, Iñigo, Ferrer, Santiago B, Jiménez-Díaz, María Belén, Gamo, Francisco-Javier, Goldsmith, Elizabeth J, Charman, William N, Bathurst, Ian, Floyd, David, Matthews, David, Burrows, Jeremy N, Rathod, Pradipsinh K, Charman, Susan A, Phillips, Margaret A

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Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral A... von White, Karen L, Nguyen, Gary, Charman, William N, Edwards, Glenn A, Faassen, W A Fried, Porter, Christopher J H

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