Quadruplex-Interactive Agents as Telomerase Inhibitors:  Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase von Shi, Dong-Fang, Wheelhouse, Richard T, Sun, Daekyu, Hurley, Laurence H

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Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials von Newlands, E.S., Stevens, M.F.G., Wedge, S.R., Wheelhouse, R.T., Brock, C.

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Cationic Porphyrins as Telomerase Inhibitors:  the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA von Wheelhouse, Richard T, Sun, Daekyu, Han, Haiyong, Han, Frank Xiaoguang, Hurley, Laurence H

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Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells von IZBICKA, E, WHEELHOUSE, R. T, RAYMOND, E, DAVIDSON, K. K, LAWRENCE, R. A, SUN, D, WINDLE, B. E, HURLEY, L. H, VON HOFF, D. D

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Mechanism for the Catalytic Activation of Ecteinascidin 743 and Its Subsequent Alkylation of Guanine N2 von Moore, Bob M, Seaman, Frederick C, Wheelhouse, Richard T, Hurley, Laurence H

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Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition von Han, Frank Xiaoguang, Wheelhouse, Richard T, Hurley, Laurence H

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Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide von Clark, A S, Deans, B, Stevens, M F, Tisdale, M J, Wheelhouse, R T, Denny, B J, Hartley, J A

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G-quadruplexes as targets for drug design von Hurley, Laurence H., Wheelhouse, Richard T., Sun, Daekyu, Kerwin, Sean M., Salazar, Miguel, Fedoroff, Oleg Yu, Han, Frank X., Han, Haiyong, Izbicka, Elzbieta, Von Hoff, Daniel D.

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NMR and Molecular Modeling Investigation of the Mechanism of Activation of the Antitumor Drug Temozolomide and Its Interaction with DNA von Denny, Brian J, Wheelhouse, Richard T, Stevens, Malcolm F. G, Tsang, Lincoln L. H, Slack, John A

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Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate von HOLLEY, J. L, MATHER, A, WHEELHOUSE, R. T, CULLIS, P. M, HARTLEY, J. A, BINGHAM, J. P, COHEN, G. M

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In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers von Shoeib, N.A, Bibby, M.C, Blunden, G, Linley, P.A, Swaine, D.J, Wheelhouse, R.T, Wright, C.W

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Drug Binding to DNA⋅RNA Hybrid Structures von Wheelhouse, Richard T., Chaires, Jonathan B.

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Antitumor Imidazotetrazines. 32.1 Synthesis of Novel Imidazotetrazinones and Related Bicyclic Heterocycles To Probe the Mode of Action of the Antitumor Drug Temozolomide von Clark, A. S, Deans, B, Stevens, M. F. G, Tisdale, M. J, Wheelhouse, R. T, Denny, B. J, Hartley, J. A

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Minor structural modifications to alchemix influence mechanism of action and pharmacological activity von Abdallah, Qasem M.A., Phillips, Roger M., Johansson, Fredrik, Helleday, Thomas, Cosentino, Laura, Abdel-Rahman, Hamdy, Etzad, Jasarat, Wheelhouse, Richard T., Kiakos, Konstantinos, Bingham, John P., Hartley, John A., Patterson, Laurence H., Pors, Klaus

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Motion of polyammonium ions on aqueous solutions of DNA von Besley, Steve, Cullis, Paul M., Partridge, Richard, Symons, Martyn C.R., Wheelhouse, Richard T.

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Polar, functionalized guanine- O6 derivatives resistant to repair by  O6 -alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs von Pletsas, Dimitrios, Wheelhouse, Richard T., Pletsa, Vassiliki, Nicolaou, Anna, Jenkins, Terence C., Bibby, Michael C., Kyrtopoulos, Soterios A.

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Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition von Han, Frank Xiaoguang, Wheelhouse, R T, Hurley, L H

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Decomposition of the antitumor drug temozolomide in deuteriated phosphate buffer : methyl group transfer is accompanied by deuterium exchange von WHEELHOUSE, R. T, STEVENS, M. F. G

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Biarylpyrimidines: a new class of ligand for high-order DNA recognition von Murphy, Peter M, Phillips, Victoria A, Jennings, Sharon A, Garbett, Nichola C, Chaires, Jonathan B, Jenkins, Terence C, Wheelhouse, Richard T

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A novel, high-yielding synthesis of meso-substituted porphyrins via the direct arylation of porphine von Shi, Dong-Fang, Wheelhouse, Richard T.

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