Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors von Whalen, Kerry A., Rakhra, Kavya, Mehta, Naveen K., Steinle, Alexander, Michaelson, Jennifer S., Baeuerle, Patrick A.

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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer von Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard

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Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors von Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.

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Polyomavirus Middle T Antigen Induces the Transcription of Osteopontin, a Gene Important for the Migration of Transformed Cells von WHALEN, Kerry A, WEBER, Georg F, BENJAMIN, Thomas L, SCHAFFHAUSEN, Brian S

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194 Characterization of the pharmacodynamic activity of CLN-619, an anti-MICA/B monoclonal antibody, in patients from an ongoing Phase 1 trial von Shapiro, Irina M, Whalen, Kerry A, Liu, Laura, Liu, Tracy, Michaelson, Jennifer S, Spira, Alexander I, Wang, Judy S, Hamilton, Erika, Millward, Michael, Arance, Ana Maria, Moreno, Victor, Melero, Ignacio, Stec, Rafal, Jones, Jeffrey A

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Genetic Analysis of the Polyomavirus DnaJ Domain von WHALEN, Kerry A, DE JESUS, Rowena, KEAN, Jennifer A, SCHAFFHAUSEN, Brian S

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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo von White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T

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Abstract CT156: Characterization of PEN-866, a Heat Shock Protein 90 (HSP90) binding conjugate of SN-38, in patient plasma and tumors from the first in human study von Thomas, Anish, Kriksciukaite, Kristina, Falchook, Gerald, Bendel, Johanna, Ulahannan, Susanna, Redon, Christophe, Mei, Laura, Whalen, Kerry, Bloss, Jeffrey, Bilodeau, Mark T.

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A phase 1 dose-escalation study to investigate the safety, efficacy, pharmacokinetics, and pharmacodynamic activity of cln-619 (Anti-MICA/B antibody) alone and in combination with... von Wang, Judy S., Gutierrez, Martin, Rasco, Drew W., Melero Bermejo, Ignacio, Powderly, John D., Hamilton, Erika P., Millward, Michael, Arance, Ana Maria, Stec, Rafal, Moreno, Victor, Sharma, Manish, Lugowska, Iwona A., Shackleton, Mark J., Frentzas, Sophia, Janik, John Edward, Liu, Tracy, Shapiro, Irina, Whalen, Kerry, Jones, Jeffrey Alan, Spira, Alexander I.

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Abstract 5806: Combination of the miniature drug conjugate PEN-866 with PARP inhibitors as a rational approach to overcoming limitations of PARP inhibitor monotherapy von Perino, Samantha, Quinn, James M., Callahan, Marrissa, Sharma, Gitanjali, White, Brian, Bilodeau, Mark, Alland, Leila, Whalen, Kerry, Wooster, Richard

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Abstract 2943: The structural basis for inhibition of MICA shedding and anti-tumor activity of the monoclonal anti-MICA|B antibody, CLN-619 von Whalen, Kerry A., Mehta, Naveen K., Meetze, Kristan, Michaelson, Jennifer S., Baeuerle, Patrick S.

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A phase 1 dose-escalation study to investigate the safety, efficacy, pharmacokinetics, and pharmacodynamic activity of CLN-619 (anti-MICA/MICB antibody) alone and in combination wi... von Powderly, John D., Gutierrez, Martin, Wang, Judy S., Hamilton, Erika P., Sharma, Manish, Spira, Alexander I., Millward, Michael, Shackleton, Mark J., Frentzas, Sophia, Koczywas, Marianna, Mehta, Naveen, Christensen, Ann Marie, Shapiro, Irina, Whalen, Kerry, Michaelson, Jennifer, Baeuerle, Patrick, Janik, John Edward, Rasco, Drew W.

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Abstract 4328: Epigenetic modulation of SSTR2 expression provides the potential to broaden PEN-221 treatment population von Perino, Samantha, Quinn, James, Freda, Jessica, White, Brian, Bailey, Scott, Bhatia, Viren, Sweryda-Krawiec, Beata, Bilodeau, Mark, Bloss, Jeffrey D., Whalen, Kerry, Wooster, Richard

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Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis von Whalen, Kerry A., Mehta, Naveen K., Yalcin, Safak, Meetze, Kristan, Gibson, Neil W., Michaelson, Jennifer S., Baeuerle, Patrick A.

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Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo von White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.

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Abstract 3674: Pentarins: Improved tumor targeting through nanoparticle encapsulation of miniaturized biologic drug conjugates von Bilodeau, Mark T., Shinde, Rajesh, White, Brian, Bazinet, Patrick, Whalen, Kerry, Dupont, Michelle, Kriksciukaite, Kristina, Quinn, Jamie, Sweryda-Krawiec, Beata, Alargova, Rossitza, Brockman, Adam, Lim Soo, Patrick, Meetze, Kristan, Moreau, Benoit, Oller, Haley, Ramstack, Mike, Rockwood, Danielle, Singh, Sukhjeet, Yeung, Tsun Au, Kadiyala, Sudha, Dunbar, Craig, Wooster, Richard

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Abstract 4484: BTP-114: An albumin binding cisplatin prodrug with improved and sustained tumor growth inhibition von Moreau, Benoit, Alargova, Rossitza, Brockman, Adam, Whalen, Kerry, Quinn, Jamie, Meetze, Kristan, Bazinet, Patrick, DuPont, Michelle, Krawiec, Beata, Kriksciukaite, Kristina, Lemelin, Charles, LimSoo, Patrick, Oller, Haley, Ramstack, Mike, Rockwood, Danielle, Shinde, Rajesh, Singh, Sukhjeet, White, Brian, AuYeung, Tsun, Dunbar, Craig, Bilodeau, Mark, Wooster, Richard

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Abstract 644: Anti-tumor activities of antibodies targeting the RON receptor and a biomarker of response von Whalen, Kerry, Gifford, James, Boudrow, Andrea, Meetze, Kristan, Winston, William, Liu, Qing, Lerner, Lorena, Feng, Bin, Jiang, Jinwei, Cook, Lynette, DiPrima, Michael, Chen, Ting, Weiler, Solly, Gyuris, Jeno, Han, May

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ANTI-MICA/B ANTIBODIES WITH ENHANCED EFFECTOR FUNCTION AND METHODS OF USE von MICHAELSON, Jennifer S, WHALEN, Kerry A, MEHTA, Naveen K, BAEUERLE, Patrick A

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HSP90-BINDING CONJUGATES AND COMBINATION THERAPIES THEREOF von MEI, Laura E, BLOSS, Jeffrey, BILODEAU, Mark T, QUINN, James M, PERINO, Samantha, WOOSTER, Richard, KRIKSCIUKAITE, Kristina, WHALEN, Kerry

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