Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice von Michalon, Aubin, Sidorov, Michael, Ballard, Theresa M., Ozmen, Laurence, Spooren, Will, Wettstein, Joseph G., Jaeschke, Georg, Bear, Mark F., Lindemann, Lothar

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Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone von Morairty, Stephen R, Revel, Florent G, Malherbe, Pari, Moreau, Jean-Luc, Valladao, Daniel, Wettstein, Joseph G, Kilduff, Thomas S, Borroni, Edilio

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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity von Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome von Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A, Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W, Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G, Hernández, Maria-Clemencia

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selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system von Bradaia, Amyaouch, Trube, Gerhard, Stalder, Henri, Norcross, Roger D, Ozmen, Laurence, Wettstein, Joseph G, Pinard, Audrée, Buchy, Danièle, Gassmann, Martin, Hoener, Marius C, Bettler, Bernhard

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The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock von Jagannath, Aarti, Butler, Rachel, Godinho, Sofia I.H., Couch, Yvonne, Brown, Laurence A., Vasudevan, Sridhar R., Flanagan, Kevin C., Anthony, Daniel, Churchill, Grant C., Wood, Matthew J.A., Steiner, Guido, Ebeling, Martin, Hossbach, Markus, Wettstein, Joseph G., Duffield, Giles E., Gatti, Silvia, Hankins, Mark W., Foster, Russell G., Peirson, Stuart N.

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Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia von Alberati, Daniela, Moreau, Jean-Luc, Lengyel, Judith, Hauser, Nicole, Mory, Roland, Borroni, Edilio, Pinard, Emmanuel, Knoflach, Frederic, Schlotterbeck, Götz, Hainzl, Dominik, Wettstein, Joseph G.

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Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice von Michalon, Aubin, Bruns, Andreas, Risterucci, Céline, Honer, Michael, Ballard, Theresa M, Ozmen, Laurence, Jaeschke, Georg, Wettstein, Joseph G, von Kienlin, Markus, Künnecke, Basil, Lindemann, Lothar

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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease von Foster, Russell G, Wulff, Katharina, Gatti, Silvia, Wettstein, Joseph G

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor von Lindemann, Lothar, Jaeschke, Georg, Michalon, Aubin, Vieira, Eric, Honer, Michael, Spooren, Will, Porter, Richard, Hartung, Thomas, Kolczewski, Sabine, Büttelmann, Bernd, Flament, Christophe, Diener, Catherine, Fischer, Christophe, Gatti, Silvia, Prinssen, Eric P, Parrott, Neil, Hoffmann, Gerhard, Wettstein, Joseph G

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Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antago... von Malherbe, Pari, Borroni, Edilio, Pinard, Emmanuel, Wettstein, Joseph G, Knoflach, Frédéric

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Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678... von Pinard, Emmanuel, Alanine, Alexander, Alberati, Daniela, Bender, Markus, Borroni, Edilio, Bourdeaux, Patrick, Brom, Virginie, Burner, Serge, Fischer, Holger, Hainzl, Dominik, Halm, Remy, Hauser, Nicole, Jolidon, Synese, Lengyel, Judith, Marty, Hans-Peter, Meyer, Thierry, Moreau, Jean-Luc, Mory, Roland, Narquizian, Robert, Nettekoven, Mathias, Norcross, Roger D, Puellmann, Bernd, Schmid, Philipp, Schmitt, Sebastien, Stalder, Henri, Wermuth, Roger, Wettstein, Joseph G, Zimmerli, Daniel

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523... von Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar

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Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome von Scharf, Sebastian H, Jaeschke, Georg, Wettstein, Joseph G, Lindemann, Lothar

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Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia: A Randomized, Double-Blind, Proof-of-Concept Study von Umbricht, Daniel, Alberati, Daniela, Martin-Facklam, Meret, Borroni, Edilio, Youssef, Eriene A, Ostland, Michael, Wallace, Tanya L, Knoflach, Frédéric, Dorflinger, Ernest, Wettstein, Joseph G, Bausch, Alexander, Garibaldi, George, Santarelli, Luca

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Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers von Harmeier, Anja, Obermueller, Stefan, Meyer, Claas A, Revel, Florent G, Buchy, Daniele, Chaboz, Sylvie, Dernick, Gregor, Wettstein, Joseph G, Iglesias, Antonio, Rolink, Antonius, Bettler, Bernhard, Hoener, Marius C

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Drug targets for cognitive enhancement in neuropsychiatric disorders von Wallace, Tanya L., Ballard, Theresa M., Pouzet, Bruno, Riedel, Wim J., Wettstein, Joseph G.

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In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu ®) and active metabolite von Lindemann, Lothar, Jacobsen, Helmut, Schuhbauer, Diana, Knoflach, Frederic, Gatti, Silvia, Wettstein, Joseph G., Loetscher, Hansruedi, Chu, Tom, Ebeling, Martin, Paulson, James C., Prinssen, Eric, Brockhaus, Manfred

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression von Lindemann, Lothar, Porter, Richard H, Scharf, Sebastian H, Kuennecke, Basil, Bruns, Andreas, von Kienlin, Markus, Harrison, Anthony C, Paehler, Axel, Funk, Christoph, Gloge, Andreas, Schneider, Manfred, Parrott, Neil J, Polonchuk, Liudmila, Niederhauser, Urs, Morairty, Stephen R, Kilduff, Thomas S, Vieira, Eric, Kolczewski, Sabine, Wichmann, Juergen, Hartung, Thomas, Honer, Michael, Borroni, Edilio, Moreau, Jean-Luc, Prinssen, Eric, Spooren, Will, Wettstein, Joseph G, Jaeschke, Georg

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Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics von Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Ferragud, Antonio, Velázquez-Sánchez, Clara, Sotnikova, Tatyana D, Morairty, Stephen R, Harmeier, Anja, Groebke Zbinden, Katrin, Norcross, Roger D, Bradaia, Amyaouch, Kilduff, Thomas S, Biemans, Barbara, Pouzet, Bruno, Caron, Marc G, Canales, Juan J, Wallace, Tanya L, Wettstein, Joseph G, Hoener, Marius C

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