Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities von Porter, Donald C, Farmaki, Elena, Altilia, Serena, Schools, Gary P, West, Deborah K, Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy T, Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence T, Papavassiliou, Athanasios G, Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S, Gyorffy, Balazs, Wentland, Mark P, Broude, Eugenia V, Kiaris, Hippokratis, Roninson, Igor B

Volltext

Syntheses of novel high affinity ligands for opioid receptors von Wentland, Mark P., Lou, Rongliang, Lu, Qun, Bu, Yigong, Denhardt, Christoph, Jin, Jin, Ganorkar, Rakesh, VanAlstine, Melissa A., Guo, Chengyun, Cohen, Dana J., Bidlack, Jean M.

Volltext

Syntheses and opioid receptor binding properties of carboxamido-substituted opioids von Wentland, Mark P., Lou, Rongliang, Lu, Qun, Bu, Yigong, VanAlstine, Melissa A., Cohen, Dana J., Bidlack, Jean M.

Volltext

Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine von Wentland, Mark P., Sun, Xufeng, Cohen, Dana J., Bidlack, Jean M.

Volltext

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling von Ding, Xinxin, Hough, Lindsay B, Conroy, Jennie L, Fang, Cheng, Gu, Jun, Zeitlin, Scott O, Yang, Weizhu, Yang, Jun, VanAlstine, Melissa A, Nalwalk, Julia W, Albrecht, Phillip J, Mazurkiewicz, Joseph E, Snyder-Keller, Abigail, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P, Behr, Melissa, Knapp, Brian I, Bidlack, Jean M, Zuiderveld, Obbe P, Leurs, Rob

Volltext

Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition von Yang, Jun, VanAlstine, Melissa A, Phillips, James G, Wentland, Mark P, Hough, Lindsay B

Volltext

Antinociceptive activity of CC44, a biotinylated improgan congener von Hoerbelt, Paul, Nalwalk, Julia W., Phillips, James G., Wentland, Mark P., Shan, Zhixing, Hough, Lindsay B.

Volltext

96-Well Plate Colorimetric Assay for Ki Determination of (+/-)-2-Benzylsuccinic Acid, an Inhibitor of Carboxypeptidase A: A Laboratory Experiment in Drug Discovery von Wentland, Mark P, Raza, Shaan, Gao, Yingtong

Volltext

Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1′-b... von Wentland, Mark P., Jo, Sunjin, Gargano, Joseph M., VanAlstine, Melissa A., Cohen, Dana J., Bidlack, Jean M.

Volltext

Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1),... von VanAlstine, Melissa A., Wentland, Mark P., Alvarez, Juan, Cao, Qing, Cohen, Dana J., Knapp, Brian I., Bidlack, Jean M.

Volltext

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic von Hough, Lindsay B., Nalwalk, Julia W., Yang, Jun, Conroy, Jennie L., VanAlstine, Melissa A., Yang, Weizhu, Gargano, Joseph, Shan, Zhixing, Zhang, Shao-Zhong, Wentland, Mark P., Phillips, James G., Knapp, Brian I., Bidlack, Jean M., Zuiderveld, Obbe P., Leurs, Rob, Ding, Xinxin

Volltext

Redefining the Structure−Activity Relationships of 2,6-Methano-3-benzazocines. 4. Opioid Receptor Binding Properties of 8-[N-(4‘-phenyl)-phenethyl)carboxamido] Analogues of Cyclazo... von Wentland, Mark P, VanAlstine, Melissa, Kucejko, Robert, Lou, Rongliang, Cohen, Dana J, Parkhill, Amy L, Bidlack, Jean M

Volltext

10-Ketomorphinan and 3-Substituted-3-desoxymorphinan Analogues as Mixed κ and μ Opioid Ligands:  Synthesis and Biological Evaluation of Their Binding Affinity at Opioid Receptors... von Zhang, Ao, Xiong, Wennan, Bidlack, Jean M, Hilbert, James E, Knapp, Brian I, Wentland, Mark P, Neumeyer, John L

Volltext

Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone von Wentland, Mark P., Lu, Qun, Lou, Rongliang, Bu, Yigong, Knapp, Brian I., Bidlack, Jean M.

Volltext

Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4′-phenyl)-phenethyl) analogues of 8-CAC von VanAlstine, Melissa A., Wentland, Mark P., Cohen, Dana J., Bidlack, Jean M.

Volltext

Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives von Wentland, Mark P, Lesher, George Y, Reuman, Michael, Gruett, Monte D, Singh, Baldev, Aldous, Suzanne C, Dorff, Peter H, Rake, James B, Coughlin, Susan A

Volltext

Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. Part 7: Syntheses and opioid receptor properties of cyclic variants of cyclazocine von Wentland, Mark P., Lu, Qun, Ganorkar, Rakesh, Zhang, Shao-Zhong, Jo, Sunjin, Cohen, Dana J., Bidlack, Jean M.

Volltext

CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist von Hough, Lindsay B., Nalwalk, Julia W., Phillips, James G., Kern, Brian, Shan, Zhixing, Wentland, Mark P., de Esch, Iwan J.P., Janssen, Elwin, Barr, Travis, Stadel, Rebecca

Volltext

8-Carboxamidocyclazocine analogues: redefining the structure–activity relationships of 2,6-methano-3-benzazocines von Wentland, Mark P., Lou, Rongliang, Ye, Yingchun, Cohen, Dana J., Richardson, Gregory P., Bidlack, Jean M.

Volltext

Effects of the mixed-action κ/μ opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys von Stevenson, Glenn W., Wentland, Mark P., Bidlack, Jean M., Mello, Nancy K., Negus, S. Stevens

Volltext