Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease von He, Gen, Luo, Wenjie, Li, Peng, Remmers, Christine, Netzer, William J., Hendrick, Joseph, Bettayeb, Karima, Flajolet, Marc, Gorelick, Fred, Wennogle, Lawrence P., Greengard, Paul

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Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission von Snyder, Gretchen L., Vanover, Kimberly E., Zhu, Hongwen, Miller, Diane B., O’Callaghan, James P., Tomesch, John, Li, Peng, Zhang, Qiang, Krishnan, Vaishnav, Hendrick, Joseph P., Nestler, Eric J., Davis, Robert E., Wennogle, Lawrence P., Mates, Sharon

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Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders von Li, Peng, Zhang, Qiang, Robichaud, Albert J, Lee, Taekyu, Tomesch, John, Yao, Wei, Beard, J. David, Snyder, Gretchen L, Zhu, Hongwen, Peng, Youyi, Hendrick, Joseph P, Vanover, Kimberly E, Davis, Robert E, Mates, Sharon, Wennogle, Lawrence P

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Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications von Heckman, Pim R. A., van Duinen, Marlies A., Bollen, Eva P. P., Nishi, Akinori, Wennogle, Lawrence P., Blokland, Arjan, Prickaerts, Jos

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Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: Translational Study in the Dog and Rabbit von Hashimoto, Toru, Kim, Grace E, Tunin, Richard S, Adesiyun, Tolulope, Hsu, Steven, Nakagawa, Ryo, Zhu, Guangshuo, O’Brien, Jennifer J, Hendrick, Joseph P, Davis, Robert E, Yao, Wei, Beard, David, Hoxie, Helen R, Wennogle, Lawrence P, Lee, Dong I, Kass, David A

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Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases von Li, Peng, Zheng, Hailin, Zhao, Jun, Zhang, Lei, Yao, Wei, Zhu, Hongwen, Beard, J. David, Ida, Koh, Lane, Weston, Snell, Gyorgy, Sogabe, Satoshi, Heyser, Charles J, Snyder, Gretchen L, Hendrick, Joseph P, Vanover, Kimberly E, Davis, Robert E, Wennogle, Lawrence P

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Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses von O'Brien, Jennifer J., O'Callaghan, James P., Miller, Diane B., Chalgeri, Suman, Wennogle, Lawrence P., Davis, Robert E., Snyder, Gretchen L., Hendrick, Joseph P.

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Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats von Snyder, Gretchen L., Prickaerts, Jos, Wadenberg, Marie-Louise, Zhang, Lei, Zheng, Hailin, Yao, Wei, Akkerman, Sven, Zhu, Hongwen, Hendrick, Joseph P., Vanover, Kimberly E., Davis, Robert, Li, Peng, Mates, Sharon, Wennogle, Lawrence P.

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Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition von van Goethem, Nick P., Paes, Dean, Puzzo, Daniela, Fedele, Ernesto, Rebosio, Claudia, Gulisano, Walter, Palmeri, Agostino, Wennogle, Lawrence P., Peng, Youyi, Bertrand, Daniel, Prickaerts, Jos

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Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels von Vanmierlo, Tim, De Vry, Jochen, Nelissen, Ellis, Sierksma, Annerieke, Roumans, Nadia, Steinbusch, Harry W.M., Wennogle, Lawrence P., van den Hove, Daniel, Prickaerts, Jos

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The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding von Picha, Kristen M., Patel, Smita S., Mandiyan, Sreekala, Koehn, James, Wennogle, Lawrence P.

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Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation von Hekman, Mirko, Fischer, Andreas, Wennogle, Lawrence P., Wang, Y. Karen, Campbell, Sharon L., Rapp, Ulf R.

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Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition von Hashimoto, Toru, Kim, Grace E, Tunin, Richard S, Adesiyun, Tolulope, Hsu, Steven, Nakagawa, Ryo, Zhu, Guangshuo, O'Brien, Jennifer J, Hendrick, Joseph P, Davis, Robert E, Yao, Wei, Beard, David, Hoxie, Helen R, Wennogle, Lawrence P, Lee, Dong I, Kass, David A

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Synthesis and Antiproliferative Activity of 7-Azaindirubin-3′-oxime, a 7-Aza Isostere of the Natural Indirubin Pharmacophore von Kritsanida, Marina, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Peng, Youyi, Li, Peng, Wennogle, Lawrence P

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Poster #T221 MECHANISM OF ACTION OF ITI-007: A NOVEL THERAPY FOR THE TREATMENT OF SCHIZOPHRENIA AND RELATED PSYCHOSES von Snyder, Gretchen L, Vanover, Kimberly, Hendick, Joseph, Yao, Wei, Li, Peng, Davis, Robert E, Wennogle, Lawrence P, Mates, Sharon

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Poster #S176 UNIQUELY TARGETED MOLECULAR THERAPEUTIC FOR SCHIZOPHRENIA: CHARACTERIZATION OF ITI-007 IN VITRO AND IN VIVO ANIMAL MODELS von Wennogle, Lawrence P, Snyder, Gretchen L, Davis, Robert E, Vanover, Kimberly, Hendrick, Joseph, Li, Peng

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Poster #S78 THE NOVEL PHARMACOLOGY OF ITI-007 IS ENHANCED AND EXTENDED BY ITS METABOLIC BACK CONVERSION FROM IC200131 von Davis, Robert E, Hendrick, Joseph, Zhang, Lei, Yao, Wei, Wennogle, Lawrence P, Zhu, Hongwen, Snyder, Gretchen L, Vanover, Kimberly, Mates, Sharon

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Nerve agent exposure elicits site-specific changes in protein phosphorylation in mouse brain von Zhu, Hongwen, O'Brien, Jennifer J, O'Callaghan, James P, Miller, Diane B, Zhang, Qiang, Rana, Minal, Tsui, Tiffany, Peng, Youyi, Tomesch, John, Hendrick, Joseph P, Wennogle, Lawrence P, Snyder, Gretchen L

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Discovery of novel α7 nicotinic receptor antagonists von Peng, Youyi, Zhang, Qiang, Snyder, Gretchen L., Zhu, Hongwen, Yao, Wei, Tomesch, John, Papke, Roger L., O’Callaghan, James P., Welsh, William J., Wennogle, Lawrence P.

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Novel C5a Receptor Antagonists Regulate Neutrophil Functions In Vitro and In Vivo von Pellas, Theodore C, Boyar, William, van Oostrum, Jan, Wasvary, James, Fryer, Lynn R, Pastor, Gary, Sills, Matthew, Braunwalder, Albert, Yarwood, Donna R, Kramer, Richard, Kimble, Earl, Hadala, Joseph, Haston, William, Moreira-Ludewig, Rocio, Uziel-Fusi, Susan, Peters, Paul, Bill, Kurt, Wennogle, Lawrence P

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