Targeting DNA Damage Response in Prostate and Breast Cancer von Wengner, Antje M, Scholz, Arne, Haendler, Bernard

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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models von Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors von Yap, Timothy A, Tan, David S P, Terbuch, Angelika, Caldwell, Reece, Guo, Christina, Goh, Boon Cher, Heong, Valerie, Haris, Noor R Md, Bashir, Saira, Drew, Yvette, Hong, David S, Meric-Bernstam, Funda, Wilkinson, Gary, Hreiki, Joseph, Wengner, Antje M, Bladt, Friedhelm, Schlicker, Andreas, Ludwig, Matthias, Zhou, Yinghui, Liu, Li, Bordia, Sonal, Plummer, Ruth, Lagkadinou, Eleni, de Bono, Johann S

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Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT von Paul, Juliane, Soujon, Maurice, Wengner, Antje M., Zitzmann-Kolbe, Sabine, Sturz, Andrea, Haike, Katja, Keng Magdalene, Koh Hui, Tan, Sze Huey, Lange, Martin, Tan, Soo Yong, Mumberg, Dominik, Lim, Soon Thye, Ziegelbauer, Karl, Liu, Ningshu

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BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application von Siemeister, Gerhard, Lücking, Ulrich, Wengner, Antje M, Lienau, Philip, Steinke, Wolfram, Schatz, Christoph, Mumberg, Dominik, Ziegelbauer, Karl

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Differential Mobilization of Subsets of Progenitor Cells from the Bone Marrow von PITCHFORD, Simon C, FURZE, Rebecca C, JONES, Carla P, WENGNER, Antje M, RANKIN, Sara M

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The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation von Wengner, Antje M., Pitchford, Simon C., Furze, Rebecca C., Rankin, Sara M.

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity von Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 von Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity von Santag, Susann, Siegel, Franziska, Wengner, Antje M, Lange, Claudia, Bömer, Ulf, Eis, Knut, Pühler, Florian, Lienau, Philip, Bergemann, Linda, Michels, Martin, von Nussbaum, Franz, Mumberg, Dominik, Petersen, Kirstin

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The ATR inhibitor elimusertib exhibits anti-lymphoma activity and synergizes with the PI3K inhibitor copanlisib von Sartori, Giulio, Tarantelli, Chiara, Spriano, Filippo, Gaudio, Eugenio, Cascione, Luciano, Mascia, Michele, Barreca, Marilia, Arribas, Alberto J, Licenziato, Luca, Golino, Gaetanina, Ferragamo, Adele, Pileri, Stefano, Damia, Giovanna, Zucca, Emanuele, Stathis, Anastasios, Politz, Oliver, Wengner, Antje M, Bertoni, Francesco

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase von Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

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Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344 von Wickstroem, Katrine, Hagemann, Urs B., Kristian, Alexander, Ellingsen, Christine, Sommer, Anette, Ellinger-Ziegelbauer, Heidrun, Wirnitzer, Uta, Hagelin, Else-Marie, Larsen, Aasmund, Smeets, Roger, Bjerke, Roger M., Karlsson, Jenny, Ryan, Olav B., Wengner, Antje M., Linden, Lars, Mumberg, Dominik, Cuthbertson, Alan S.

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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies von Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard

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Targeted thorium-227 conjugates as treatment options in oncology von Karlsson, Jenny, Schatz, Christoph A, Wengner, Antje M, Hammer, Stefanie, Scholz, Arne, Cuthbertson, Alan, Wagner, Volker, Hennekes, Hartwig, Jardine, Vicki, Hagemann, Urs B

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Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models von Wickstroem, Katrine, Hagemann, Urs B, Cruciani, Véronique, Wengner, Antje M, Kristian, Alexander, Ellingsen, Christine, Siemeister, Gerhard, Bjerke, Roger M, Karlsson, Jenny, Ryan, Olav B, Linden, Lars, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S

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Synergistic Effect of a Mesothelin-Targeted 227 Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models von Wickstroem, Katrine, Hagemann, Urs B, Cruciani, Véronique, Wengner, Antje M, Kristian, Alexander, Ellingsen, Christine, Siemeister, Gerhard, Bjerke, Roger M, Karlsson, Jenny, Ryan, Olav B, Linden, Lars, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S

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CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity von Höpken, Uta E., Wengner, Antje M., Loddenkemper, Christoph, Stein, Harald, Heimesaat, Markus M., Rehm, Armin, Lipp, Martin

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