Shifting from the single to the multitarget paradigm in drug discovery von Medina-Franco, José L., Giulianotti, Marc A., Welmaker, Gregory S., Houghten, Richard A.

Volltext

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens von Fleeman, Renee, LaVoi, Travis M, Santos, Radleigh G, Morales, Angela, Nefzi, Adel, Welmaker, Gregory S, Medina-Franco, José L, Giulianotti, Marc A, Houghten, Richard A, Shaw, Lindsey N

Volltext

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens von Fleeman, Renee M, Debevec, Ginamarie, Antonen, Kirsten, Adams, Jessie L, Santos, Radleigh G, Welmaker, Gregory S, Houghten, Richard A, Giulianotti, Marc A, Shaw, Lindsey N

Volltext

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats von Wu, Jinhua, Cippitelli, Andrea, Zhang, Yaohong, Debevec, Ginamarie, Schoch, Jennifer, Ozawa, Akihiko, Yu, Yongping, Liu, Huan, Chen, Wenteng, Houghten, Richard A, Welmaker, Gregory S, Giulianotti, Marc A, Toll, Lawrence

Volltext

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs von Cippitelli, Andrea, Brunori, Gloria, Schoch, Jennifer, Armishaw, Christopher J., Wu, Jinhua, Zaveri, Nurulain T., Giulianotti, Marc A., Welmaker, Gregory S., Toll, Lawrence

Volltext

Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies von Wu, Jinhua, Zhang, Yaohong, Maida, Laura E, Santos, Radleigh G, Welmaker, Gregory S, LaVoi, Travis M, Nefzi, Adel, Yu, Yongping, Houghten, Richard A, Toll, Lawrence, Giulianotti, Marc A

Volltext

A microwave-assisted, green procedure for the synthesis of N-aryl sulfonyl and N-aryl pyrroles von Wilson, Matthew A., Filzen, Gary, Welmaker, Gregory S.

Volltext

Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides von Moore, William J, Kern, Jeffrey C, Bhat, Ramesh, Commons, Thomas J, Fukayama, Shoichi, Goljer, Igor, Krishnamurthy, Girija, Magolda, Ronald L, Nogle, Lisa, Pitts, Keith, Stauffer, Barb, Trybulski, Eugene J, Welmaker, Gregory S, Wilson, Matthew, Bodine, Peter V. N

Volltext

A process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4]diazepino[6,7,1-hi]indole von Welmaker, Gregory S, Sabalski, Joan E

Volltext

Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor von SABB, Annmarie L, VOGEL, Robert L, WELMAKER, Gregory S, SABALSKI, A. Joan E, COUPET, Joseph, DUNLOP, B. John, ROSENZWEIG-LIPSON, Sharon, HARRISON, Boyd

Volltext

Identification of novel chemotherapies targeting mitochondrial‐cell communication von Paudel, Iru, Giulianotti, Marc, Welmaker, Gregory, Chambers, Jeremy

Volltext

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation von Bodine, Peter V.N, Stauffer, Barbara, Ponce-de-Leon, Helga, Bhat, Ramesh A, Mangine, Annamarie, Seestaller-Wehr, Laura M, Moran, Robert A, Billiard, Julia, Fukayama, Shoichi, Komm, Barry S, Pitts, Keith, Krishnamurthy, Girija, Gopalsamy, Ariamala, Shi, Mengxiao, Kern, Jeffrey C, Commons, Thomas J, Woodworth, Richard P, Wilson, Matthew A, Welmaker, Gregory S, Trybulski, Eugene J, Moore, William J

Volltext

Mannich Biscyclizations. Total Synthesis of (-)-Ajmalicine von Loegers, Michael, Overman, Larry E, Welmaker, Gregory S

Volltext

Enantioselective Synthesis of (+)- and (-)-Muricatacin through SE2' Addition of Nonracemic .gamma.-Silyloxy Allylic Stannanes to Aldehydes von Marshall, James A, Welmaker, Gregory S

Volltext

(Z)- and (E)-.gamma.-silyloxy allylic stannanes. Highly syn selective reagents for SE' additions to aldehydes von Marshall, James A, Welmaker, Gregory S

Volltext

On the Relative Reactivities of Allyl, Crotyl, α-Oxygenated Crotyl, γ-Oxygenated α-Methylallyl, and Allenyl Tri-n-butylstannane Reagents in Lewis Acid Promoted Additions to Aldehyd... von Marshall, James A, Jablonowski, Jill A, Welmaker, Gregory S

Volltext

A Convenient Method for the Preparation of 3-Substituted Glutarate Diesters von Leotta, Gus J, Overman, Larry E, Welmaker, Gregory S

Volltext

A process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7b H-cyclopenta[ b][1,4]diazepino[6,7,1- hi]indole von Welmaker, Gregory S, Sabalski, Joan E

Volltext

Cycloalkyl[ b][1,4]benzodiazepinoindoles are agonists at the human 5-HT 2C receptor von Sabb, Annmarie L., Vogel, Robert L., Welmaker, Gregory S., Sabalski, Joan E., Coupet, Joseph, Dunlop, John, Rosenzweig-Lipson, Sharon, Harrison, Boyd

Volltext

Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a, 5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines von WELMAKER, G. S, NELSON, J. A, ROSENZWEIG-LIPSON, S, SUKOFF, S, YINGXIN ZHANG, SABALSKI, J. E, SABB, A. L, POTOSKI, J. R, GRAZIANO, D, KAGAN, M, COUPET, J, DUNLOP, J, MAZANDARANI, H

Volltext