Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis von Ordureau, Alban, Sarraf, Shireen A., Duda, David M., Heo, Jin-Mi, Jedrychowski, Mark P., Sviderskiy, Vladislav O., Olszewski, Jennifer L., Koerber, James T., Xie, Tiao, Beausoleil, Sean A., Wells, James A., Gygi, Steven P., Schulman, Brenda A., Harper, J. Wade

Volltext

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 von Cotton, Adam D, Nguyen, Duy P, Gramespacher, Josef A, Seiple, Ian B, Wells, James A

Volltext

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions von Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.

Volltext

Caspase Substrates and Cellular Remodeling von Crawford, Emily D, Wells, James A

Volltext

Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males von Yang, Cindy F., Chiang, Michael C., Gray, Daniel C., Prabhakaran, Mahalakshmi, Alvarado, Maricruz, Juntti, Scott A., Unger, Elizabeth K., Wells, James A., Shah, Nirao M.

Volltext

Redox-based reagents for chemoselective methionine bioconjugation von Lin, Shixian, Yang, Xiaoyu, Jia, Shang, Weeks, Amy M., Hornsby, Michael, Lee, Peter S., Nichiporuk, Rita V., Iavarone, Anthony T., Wells, James A., Toste, F. Dean, Chang, Christopher J.

Volltext

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 von Glasgow, Anum, Glasgow, Jeff, Limonta, Daniel, Solomon, Paige, Lui, Irene, Zhang, Yang, Nix, Matthew A., Rettko, Nicholas J., Zha, Shoshana, Yamin, Rachel, Kao, Kevin, Rosenberg, Oren S., Ravetch, Jeffrey V., Wiita, Arun P., Leung, Kevin K., Lim, Shion A., Zhou, Xin X., Hobman, Tom C., Kortemme, Tanja, Wells, James A.

Volltext

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites von Cimermancic, Peter, Weinkam, Patrick, Rettenmaier, T. Justin, Bichmann, Leon, Keedy, Daniel A., Woldeyes, Rahel A., Schneidman-Duhovny, Dina, Demerdash, Omar N., Mitchell, Julie C., Wells, James A., Fraser, James S., Sali, Andrej

Volltext

Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator von Zhuang, Min, Guan, Shenheng, Wang, Haopeng, Burlingame, Alma L., Wells, James A.

Volltext

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries von Zhou, Jie, Li, Shantao, Leung, Kevin K., O’Donovan, Brian, Zou, James Y., DeRisi, Joseph L., Wells, James A.

Volltext

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering von Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S

Volltext

Caspases and their substrates von Julien, Olivier, Wells, James A

Volltext

Sampling the N-terminal proteome of human blood von Wildes, David, Wells, James A.

Volltext

A reactivity-based probe of the intracellular labile ferrous iron pool von Spangler, Benjamin, Morgan, Charles W, Fontaine, Shaun D, Vander Wal, Mark N, Chang, Christopher J, Wells, James A, Renslo, Adam R

Volltext

Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation von Thomsen, Nathan D., Koerber, James T., Wells, James A.

Volltext

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles von Julien, Olivier, Zhuang, Min, Wiita, Arun P., O’Donoghue, Anthony J., Knudsen, Giselle M., Craik, Charles S., Wells, James A.

Volltext

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity von Nguyen, Duy P., Miyaoka, Yuichiro, Gilbert, Luke A., Mayerl, Steven J., Lee, Brian H., Weissman, Jonathan S., Conklin, Bruce R., Wells, James A.

Volltext

An Improved Single-Chain Fab Platform for Efficient Display and Recombinant Expression von Koerber, James T., Hornsby, Michael J., Wells, James A.

Volltext

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation von Elledge, Susanna K., Tran, Hai L., Christian, Alec H., Steri, Veronica, Hann, Byron, Toste, F. Dean, Chang, Christopher J., Wells, James A.

Volltext

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells von Kirkemo, Lisa L, Elledge, Susanna K, Yang, Jiuling, Byrnes, James R, Glasgow, Jeff E, Blelloch, Robert, Wells, James A

Volltext