Impact of Oral Chlorhexidine on Bloodstream Infection in Critically Ill Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials von Silvestri, Luciano, MD, Weir, William I., MA, MB, BChir, Gregori, Dario, MA, PhD, Taylor, Nia, MPhil, Zandstra, Durk F., MD, PhD, van Saene, Joris J.M., PhD, van Saene, Hendrick K.F., MD, PhD

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Commentary: Cardiothoracic surgery and COVID: Must we coexist?Central Message von William Weir, MD, Leah Schoel, MD, Gorav Ailawadi, MD, MBA

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Measuring Loss of Life, Health, and Income Due to Disease and Injury: A Method for Combining Morbidity, Mortality, and Direct Medical Cost into a Single Measure of Disease Impact von Dean, Andrew G., David J. West, William M. Weir

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Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells von Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad

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Defining a Cancer Dependency Map von Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.

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Genome partitioning of genetic variation for complex traits using common SNPs von Yang, Jian, Manolio, Teri A, Pasquale, Louis R, Boerwinkle, Eric, Caporaso, Neil, Cunningham, Julie M, de Andrade, Mariza, Feenstra, Bjarke, Feingold, Eleanor, Hayes, M Geoffrey, Hill, William G, Landi, Maria Teresa, Alonso, Alvaro, Lettre, Guillaume, Lin, Peng, Ling, Hua, Lowe, William, Mathias, Rasika A, Melbye, Mads, Pugh, Elizabeth, Cornelis, Marilyn C, Weir, Bruce S, Goddard, Michael E, Visscher, Peter M

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An analysis of the attrition of drug candidates from four major pharmaceutical companies von Waring, Michael J., Arrowsmith, John, Leach, Andrew R., Leeson, Paul D., Mandrell, Sam, Owen, Robert M., Pairaudeau, Garry, Pennie, William D., Pickett, Stephen D., Wang, Jibo, Wallace, Owen, Weir, Alex

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Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits von Zhu, Zhihong, Bakshi, Andrew, Vinkhuyzen, Anna A.E., Hemani, Gibran, Lee, Sang Hong, Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Hill, William G., Weir, Bruce S., Goddard, Michael E., Visscher, Peter M., Yang, Jian

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Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal von Burkewitz, Kristopher, Morantte, Ianessa, Weir, Heather J.M., Yeo, Robin, Zhang, Yue, Huynh, Frank K., Ilkayeva, Olga R., Hirschey, Matthew D., Grant, Ana R., Mair, William B.

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Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting von Aguirre, Andrew J, Meyers, Robin M, Weir, Barbara A, Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F, Doshi, Mihir B, Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D, Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D, Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S, Garraway, Levi A, Stegmaier, Kimberly, Roberts, Charles W, Golub, Todd R, Meyerson, Matthew, Root, David E, Tsherniak, Aviad, Hahn, William C

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SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study von Letizia, Andrew G, Ge, Yongchao, Vangeti, Sindhu, Goforth, Carl, Weir, Dawn L, Kuzmina, Natalia A, Balinsky, Corey A, Chen, Hua Wei, Ewing, Dan, Soares-Schanoski, Alessandra, George, Mary-Catherine, Graham, William D, Jones, Franca, Bharaj, Preeti, Lizewski, Rhonda A, Lizewski, Stephen E, Marayag, Jan, Marjanovic, Nada, Miller, Clare M, Mofsowitz, Sagie, Nair, Venugopalan D, Nunez, Edgar, Parent, Danielle M, Porter, Chad K, Santa Ana, Ernesto, Schilling, Megan, Stadlbauer, Daniel, Sugiharto, Victor A, Termini, Michael, Sun, Peifang, Tracy, Russell P, Krammer, Florian, Bukreyev, Alexander, Ramos, Irene, Sealfon, Stuart C

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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 von Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles Wm, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

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Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience von Rose, Tracy L., Weir, William H., Mayhew, Gregory M., Shibata, Yoichiro, Eulitt, Patrick, Uronis, Joshua M., Zhou, Mi, Nielsen, Matthew, Smith, Angela B., Woods, Michael, Hayward, Michele C., Salazar, Ashley H., Milowsky, Matthew I., Wobker, Sara E., McGinty, Katrina, Millburn, Michael V., Eisner, Joel R., Kim, William Y.

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The rising Great Plains fire campaign: citizens' response to woody plant encroachment von Twidwell, Dirac, Rogers, William E, Fuhlendorf, Samuel D, Wonkka, Carissa L, Engle, David M, Weir, John R, Kreuter, Urs P, Taylor, Charles A

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Increased risk of influenza among vaccinated adults who are obese von Neidich, S D, Green, W D, Rebeles, J, Karlsson, E A, Schultz-Cherry, S, Noah, T L, Chakladar, S, Hudgens, M G, Weir, S S, Beck, M A

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New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race von Inker, Lesley A, Eneanya, Nwamaka D, Coresh, Josef, Tighiouart, Hocine, Wang, Dan, Sang, Yingying, Crews, Deidra C, Doria, Alessandro, Estrella, Michelle M, Froissart, Marc, Grams, Morgan E, Greene, Tom, Grubb, Anders, Gudnason, Vilmundur, Gutiérrez, Orlando M, Kalil, Roberto, Karger, Amy B, Mauer, Michael, Navis, Gerjan, Nelson, Robert G, Poggio, Emilio D, Rodby, Roger, Rossing, Peter, Rule, Andrew D, Selvin, Elizabeth, Seegmiller, Jesse C, Shlipak, Michael G, Torres, Vicente E, Yang, Wei, Ballew, Shoshana H, Couture, Sara J, Powe, Neil R, Levey, Andrew S

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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke von Ma, Henry, Campbell, Bruce C.V, Parsons, Mark W, Churilov, Leonid, Levi, Christopher R, Hsu, Chung, Kleinig, Timothy J, Wijeratne, Tissa, Curtze, Sami, Dewey, Helen M, Miteff, Ferdinand, Tsai, Chon-Haw, Lee, Jiunn-Tay, Phan, Thanh G, Mahant, Neil, Sun, Mu-Chien, Krause, Martin, Sturm, Jonathan, Grimley, Rohan, Chen, Chih-Hung, Hu, Chaur-Jong, Wong, Andrew A, Field, Deborah, Sun, Yu, Barber, P. Alan, Sabet, Arman, Jannes, Jim, Jeng, Jiann-Shing, Clissold, Benjamin, Markus, Romesh, Lin, Ching-Huang, Lien, Li-Ming, Bladin, Christopher F, Christensen, Søren, Yassi, Nawaf, Sharma, Gagan, Bivard, Andrew, Desmond, Patricia M, Yan, Bernard, Mitchell, Peter J, Thijs, Vincent, Carey, Leeanne, Meretoja, Atte, Davis, Stephen M, Donnan, Geoffrey A

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Improvement of Quality in Publication of Experimental Thermophysical Property Data: Challenges, Assessment Tools, Global Implementation, and Online Support von Chirico, Robert D, Frenkel, Michael, Magee, Joseph W, Diky, Vladimir, Muzny, Chris D, Kazakov, Andrei F, Kroenlein, Kenneth, Abdulagatov, Ilmutdin, Hardin, Gary R, Acree, William E, Brenneke, Joan F, Brown, Paul L, Cummings, Peter T, de Loos, Theo W, Friend, Daniel G, Goodwin, Anthony R. H, Hansen, Lee D, Haynes, William M, Koga, Nobuyoshi, Mandelis, Andreas, Marsh, Kenneth N, Mathias, Paul M, McCabe, Clare, O’Connell, John P, Pádua, Agilio, Rives, Vicente, Schick, Christoph, Trusler, J. P. Martin, Vyazovkin, Sergey, Weir, Ron D, Wu, Jiangtao

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Small-molecule targeting of brachyury transcription factor addiction in chordoma von Sharifnia, Tanaz, Wawer, Mathias J., Chen, Ting, Huang, Qing-Yuan, Weir, Barbara A., Sizemore, Ann, Lawlor, Matthew A., Goodale, Amy, Cowley, Glenn S., Vazquez, Francisca, Ott, Christopher J., Francis, Joshua M., Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley E., Zhang, Tinghu, Gray, Nathanael S., Clarke, Paul A., Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David E., Hahn, William C., Bradner, James E., Wong, Kwok K., Clemons, Paul A., Lin, Charles Y., Kotz, Joanne D., Schreiber, Stuart L.

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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells von Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., Garraway, Levi A.

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