Regulation of inflammation by the protein C system von Weiler, Hartmut

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A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII von Fahs, Scot A., Hille, Matthew T., Shi, Qizhen, Weiler, Hartmut, Montgomery, Robert R.

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Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells von Giri, Hemant, Panicker, Sumith R., Cai, Xiaofeng, Biswas, Indranil, Weiler, Hartmut, Rezaie, Alireza R.

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Thrombin promotes diet-induced obesity through fibrin-driven inflammation von Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J

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Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases von Geurts, Aron M, Cost, Gregory J, Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C, Choi, Vivian M, Jenkins, Shirin S, Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Jacob, Howard J, Buelow, Roland

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The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse von Kanaji, Sachiko, Morodomi, Yosuke, Weiler, Hartmut, Zarpellon, Alessandro, Montgomery, Robert R, Ruggeri, Zaverio M, Kanaji, Taisuke

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Tissue factor pathway inhibitor is required for cerebrovascular development in mice von Maroney, Susan A., Westrick, Randal J., Cleuren, Audrey C., Martinez, Nicholas D., Siebert, Amy E., Zogg, Mark, Ginsburg, David, Weiler, Hartmut, Mast, Alan E.

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Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model von Xue, Meilang, Jackson, Christopher J, Lin, Haiyan, Zhao, Ruilong, Liang, Hai Po H, Weiler, Hartmut, Griffin, John H, March, Lyn

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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis von Isermann, Berend, Nawroth, Peter P, Bierhaus, Angelika, Herzog, Stefanie, Corat, Marcus A F, Weiler, Hartmut, Grinnell, Brian W, Kashif, Muhammed, Blautzik, Janusch, Berg, David T, Madhusudhan, Thati, Esmon, Charles T, Vinnikov, Ilya A, Blessing, Erwin, Oh, Jun, Zeier, Martin, Gerlitz, Bruce, Chavakis, Triantafyllos

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Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation von Dinarvand, Peyman, Hassanian, Seyed Mahdi, Weiler, Hartmut, Rezaie, Alireza R.

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Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity von Geiger, Hartmut, Pawar, Snehalata A, Kerschen, Edward J, Nattamai, Kalpana J, Hernandez, Irene, Liang, Hai Po H, Fernández, Jose Á, Cancelas, Jose A, Ryan, Marnie A, Kustikova, Olga, Schambach, Axel, Fu, Qiang, Wang, Junru, Fink, Louis M, Petersen, Karl-Uwe, Zhou, Daohong, Griffin, John H, Baum, Christopher, Weiler, Hartmut, Hauer-Jensen, Martin

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C von Kerschen, Edward J, Fernandez, José A, Cooley, Brian C, Yang, Xia V, Sood, Rashmi, Mosnier, Laurent O, Castellino, Francis J, Mackman, Nigel, Griffin, John H, Weiler, Hartmut

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Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin von Sridharan, Vijayalakshmi, Johnson, Kristin A, Landes, Reid D, Cao, Maohua, Singh, Preeti, Wagoner, Gail, Hayar, Abdallah, Sprick, Emily D, Eveld, Kayla A, Bhattacharyya, Anusha, Krager, Kimberly J, Aykin-Burns, Nukhet, Weiler, Hartmut, Fernández, Jose A, Griffin, John H, Boerma, Marjan

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Blocking hemophilic arthropathy von Shi, Qizhen, Weiler, Hartmut

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Coagulation Factor IIIa ( f3a ) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype von Subramaniam, Saravanan, Liu, Jiandong, Fletcher, Craig, Ramchandran, Ramani, Weiler, Hartmut

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Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice von Pathak, Rupak, Shao, Lijian, Ghosh, Sanchita P, Zhou, Daohong, Boerma, Marjan, Weiler, Hartmut, Hauer-Jensen, Martin

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Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice von Kerschen, Edward, Hernandez, Irene, Zogg, Mark, Jia, Shuang, Hessner, Martin J, Fernandez, Jose A, Griffin, John H, Huettner, Claudia S, Castellino, Francis J, Weiler, Hartmut

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Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice von Gao, Chunyan, Schroeder, Jocelyn A., Xue, Feng, Jing, Weiqing, Cai, Yuanhua, Scheck, Amelia, Subramaniam, Saravanan, Rao, Sridhar, Weiler, Hartmut, Czechowicz, Agnieszka, Shi, Qizhen

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Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells von Chen, Yuhong, Yu, Mei, Dai, Xuezhi, Zogg, Mark, Wen, Renren, Weiler, Hartmut, Wang, Demin

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Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma von Bansal, Shivani, Li, Yaoxiang, Bansal, Sunil, Klotzbier, William, Singh, Baldev, Jayatilake, Meth, Sridharan, Vijayalakshmi, Fernández, José A, Griffin, John H, Weiler, Hartmut, Boerma, Marjan, Cheema, Amrita K

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