The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking von Meissner, Cathrin, Lorenz, Holger, Weihofen, Andreas, Selkoe, Dennis J., Lemberg, Marius K.

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models von Weihofen, Andreas, Liu, YuTing, Arndt, Joseph W., Huy, Christian, Quan, Chao, Smith, Benjamin A., Baeriswyl, Jean-Luc, Cavegn, Nicole, Senn, Luzia, Su, Lihe, Marsh, Galina, Auluck, Pavan K., Montrasio, Fabio, Nitsch, Roger M., Hirst, Warren D., Cedarbaum, Jesse M., Pepinsky, R. Blake, Grimm, Jan, Weinreb, Paul H.

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LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model von Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.

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Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson's Disease? von Bantle, Collin M, Hirst, Warren D, Weihofen, Andreas, Shlevkov, Evgeny

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Neurodegeneration and neuroinflammation are linked, but independent of alpha‐synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease von Garcia, Pierre, Jürgens‐Wemheuer, Wiebke, Uriarte Huarte, Oihane, Michelucci, Alessandro, Masuch, Annette, Brioschi, Simone, Weihofen, Andreas, Koncina, Eric, Coowar, Djalil, Heurtaux, Tony, Glaab, Enrico, Balling, Rudi, Sousa, Carole, Kaoma, Tony, Nicot, Nathalie, Pfander, Tatjana, Schulz‐Schaeffer, Walter, Allouche, Ahmad, Fischer, Nicolas, Biber, Knut, Kleine‐Borgmann, Felix, Mittelbronn, Michel, Ostaszewski, Marek, Schmit, Kristopher J., Buttini, Manuel

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Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1 von Weihofen, Andreas, Ostaszewski, Beth, Minami, Yasufumi, Selkoe, Dennis J.

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α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease von Cole, Tracy A, Zhao, Hien, Collier, Timothy J, Sandoval, Ivette, Sortwell, Caryl E, Steece-Collier, Kathy, Daley, Brian F, Booms, Alix, Lipton, Jack, Welch, Mackenzie, Berman, Melissa, Jandreski, Luke, Graham, Danielle, Weihofen, Andreas, Celano, Stephanie, Schulz, Emily, Cole-Strauss, Allyson, Luna, Esteban, Quach, Duc, Mohan, Apoorva, Bennett, C Frank, Swayze, Eric E, Kordasiewicz, Holly B, Luk, Kelvin C, Paumier, Katrina L

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Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease von Weihofen, Andreas, Binns, Kathleen, Lemberg, Marius K., Ashman, Keith, Martoglio, Bruno

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Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice von Driscoll, Rachelle, Hampton, Lucas, Abraham, Neeta A., Larigan, J. Douglas, Joseph, Nadine F., Hernandez-Vega, Juan C., Geisler, Sarah, Yang, Fu-Chia, Deninger, Matthew, Tran, David T., Khatri, Natasha, Godinho, Bruno M. D. C., Kinberger, Garth A., Montagna, Daniel R., Hirst, Warren D., Guardado, Catherine L., Glajch, Kelly E., Arnold, H. Moore, Gallant-Behm, Corrie L., Weihofen, Andreas

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LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model von Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.

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Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase von Shlevkov, Evgeny, Murugan, Paramasivam, Montagna, Dan, Stefan, Eric, Hadzipasic, Adelajda, Harvey, James S., Kumar, P. Rajesh, Entova, Sonya, Bansal, Nupur, Bickford, Shari, Wong, Lai-Yee, Hirst, Warren D., Weihofen, Andreas, Silvian, Laura F.

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LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model von Zhao, Hien Tran, John, Neena, Delic, Vedad, Ikeda-Lee, Karli, Kim, Aneeza, Weihofen, Andreas, Swayze, Eric E., Kordasiewicz, Holly B., West, Andrew B., Volpicelli-Daley, Laura A.

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Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes von Lemberg, Marius K, Bland, Felicity A, Weihofen, Andreas, Braud, Veronique M, Martoglio, Bruno

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Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins von Friedmann, Elena, Lemberg, Marius K., Weihofen, Andreas, Dev, Kumlesh K., Dengler, Uwe, Rovelli, Giorgio, Martoglio, Bruno

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Release of Signal Peptide Fragments into the Cytosol Requires Cleavage in the Transmembrane Region by a Protease Activity That Is Specifically Blocked by a Novel Cysteine Protease... von Weihofen, Andreas, Lemberg, Marius K., Ploegh, Hidde L., Bogyo, Matthew, Martoglio, Bruno

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Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054 von Brys, Miroslaw, Fanning, Laura, Hung, Serena, Ellenbogen, Aaron, Penner, Natalia, Yang, Minhua, Welch, Mackenzie, Koenig, Erica, David, Eric, Fox, Tara, Makh, Shavy, Aldred, Jason, Goodman, Ira, Pepinsky, Blake, Liu, YuTing, Graham, Danielle, Weihofen, Andreas, Cedarbaum, Jesse M.

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A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice von Nuber, Silke, Nam, Alice Y., Rajsombath, Molly M., Cirka, Haley, Hronowski, Xiaoping, Wang, Junmin, Hodgetts, Kevin, Kalinichenko, Liubov S., Müller, Christian P., Lambrecht, Vera, Winkler, Jürgen, Weihofen, Andreas, Imberdis, Thibaut, Dettmer, Ulf, Fanning, Saranna, Selkoe, Dennis J.

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Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking von Weihofen, Andreas, Thomas, Kelly Jean, Ostaszewski, Beth L, Cookson, Mark R, Selkoe, Dennis J

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides von Weihofen, Andreas, Martoglio, Bruno

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Dopamine covalently modifies and functionally inactivates parkin von LaVoie, Matthew J, Ostaszewski, Beth L, Weihofen, Andreas, Schlossmacher, Michael G, Selkoe, Dennis J

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