Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones von Maianti, Juan Pablo, McFedries, Amanda, Foda, Zachariah H., Kleiner, Ralph E., Du, Xiu Quan, Leissring, Malcolm A., Tang, Wei-Jen, Charron, Maureen J., Seeliger, Markus A., Saghatelian, Alan, Liu, David R.

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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism von Tang, Wei-Jen, Shen, Yuequan, Joachimiak, Andrzej, Rich Rosner, Marsha

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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus von Tang, Wei-Jen

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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme von Ren, Min, Guo, Qing, Guo, Liang, Lenz, Martin, Qian, Feng, Koenen, Rory R, Xu, Hua, Schilling, Alexander B, Weber, Christian, Ye, Richard D, Dinner, Aaron R, Tang, Wei-Jen

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In vivo epidermal migration requires focal adhesion targeting of ACF7 von Yue, Jiping, Zhang, Yao, Liang, Wenguang G., Gou, Xuewen, Lee, Philbert, Liu, Han, Lyu, Wanqing, Tang, Wei-Jen, Chen, Shao-Yu, Yang, Feng, Liang, Hong, Wu, Xiaoyang

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Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition von Liang, Wenguang G., Wijaya, Juwina, Wei, Hui, Noble, Alex J., Mancl, Jordan M., Mo, Swansea, Lee, David, Lin King, John V., Pan, Man, Liu, Chang, Koehler, Carla M., Zhao, Minglei, Potter, Clinton S., Carragher, Bridget, Li, Sheng, Tang, Wei-Jen

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Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3 von Liang, Wenguang G., Triandafillou, Catherine G., Huang, Teng-Yi, Zulueta, Medel Manuel L., Banerjee, Shiladitya, Dinner, Aaron R., Hung, Shang-Cheng, Tang, Wei-Jen

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The adenylyl cyclase activity of anthrax edema factor von Tang, Wei-Jen, Guo, Qing

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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme von Zhang, Zhening, Liang, Wenguang G, Bailey, Lucas J, Tan, Yong Zi, Wei, Hui, Wang, Andrew, Farcasanu, Mara, Woods, Virgil A, McCord, Lauren A, Lee, David, Shang, Weifeng, Deprez-Poulain, Rebecca, Deprez, Benoit, Liu, David R, Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A, Li, Sheng, Carragher, Bridget, Potter, Clinton S, Tang, Wei-Jen

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice von Deprez-Poulain, Rebecca, Hennuyer, Nathalie, Bosc, Damien, Liang, Wenguang G., Enée, Emmanuelle, Marechal, Xavier, Charton, Julie, Totobenazara, Jane, Berte, Gonzague, Jahklal, Jouda, Verdelet, Tristan, Dumont, Julie, Dassonneville, Sandrine, Woitrain, Eloise, Gauriot, Marion, Paquet, Charlotte, Duplan, Isabelle, Hermant, Paul, Cantrelle, François- Xavier, Sevin, Emmanuel, Culot, Maxime, Landry, Valerie, Herledan, Adrien, Piveteau, Catherine, Lippens, Guy, Leroux, Florence, Tang, Wei-Jen, van Endert, Peter, Staels, Bart, Deprez, Benoit

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Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA... von Beste, Kerstin Y, Spangler, Corinna M, Burhenne, Heike, Koch, Karl-Wilhelm, Shen, Yuequan, Tang, Wei-Jen, Kaever, Volkhard, Seifert, Roland

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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme von McCord, Lauren A., Liang, Wenguang G., Dowdell, Evan, Kalas, Vasilios, Hoey, Robert J., Koide, Akiko, Koide, Shohei, Tang, Wei-Jen

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Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease von King, John V., Liang, Wenguang G., Scherpelz, Kathryn P., Schilling, Alexander B., Meredith, Stephen C., Tang, Wei-Jen

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ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics von Ma, Yanlei, Yue, Jiping, Zhang, Yao, Shi, Chenzhang, Odenwald, Matt, Liang, Wenguang G., Wei, Qing, Goel, Ajay, Gou, Xuewen, Zhang, Jamie, Chen, Shao-Yu, Tang, Wei-Jen, Turner, Jerrold R., Yang, Feng, Liang, Hong, Qin, Huanlong, Wu, Xiaoyang

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Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin von Leissring, Malcolm A, Malito, Enrico, Hedouin, Sabrine, Reinstatler, Lael, Sahara, Tomoko, Abdul-Hay, Samer O, Choudhry, Shakeel, Maharvi, Ghulam M, Fauq, Abdul H, Huzarska, Malwina, May, Philip S, Choi, Sungwoon, Logan, Todd P, Turk, Benjamin E, Cantley, Lewis C, Manolopoulou, Marika, Tang, Wei-Jen, Stein, Ross L, Cuny, Gregory D, Selkoe, Dennis J

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Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin von Guo, Qing, Shen, Yuequan, Lee, Young-Sam, Gibbs, Craig S, Mrksich, Milan, Tang, Wei-Jen

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Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme von Charton, Julie, Gauriot, Marion, Totobenazara, Jane, Hennuyer, Nathalie, Dumont, Julie, Bosc, Damien, Marechal, Xavier, Elbakali, Jamal, Herledan, Adrien, Wen, Xiaoan, Ronco, Cyril, Gras-Masse, Helene, Heninot, Antoine, Pottiez, Virginie, Landry, Valerie, Staels, Bart, Liang, Wenguang G., Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca

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Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme von Manolopoulou, Marika, Guo, Qing, Malito, Enrico, Schilling, Alexander B., Tang, Wei-Jen

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Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor von Mrksich, Milan, Min, Dal-Hee, Tang, Wei-Jen

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Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor von Shen, Yuequan, Zhukovskaya, Natalia L, Guo, Qing, Florián, Jan, Tang, Wei-Jen

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