Fundamental Mechanisms of Immune Checkpoint Blockade Therapy von Wei, Spencer C, Duffy, Colm R, Allison, James P

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Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition von Wei, Spencer C, Yang, Jing

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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade von Wei, Spencer C., Levine, Jacob H., Cogdill, Alexandria P., Zhao, Yang, Anang, Nana-Ama A.S., Andrews, Miles C., Sharma, Padmanee, Wang, Jing, Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

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Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies von Wei, Spencer C., Anang, Nana-Ama A. S., Sharma, Roshan, Andrews, Miles C., Reuben, Alexandre, Levine, Jacob H., Cogdill, Alexandria P., Mancuso, James J., Wargo, Jennifer A., Pe’er, Dana, Allison, James P.

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Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer von Ma, Ying, Li, Jun, Wang, Huamin, Chiu, Yulun, Kingsley, Charles V., Fry, David, Delaney, Samantha N., Wei, Spencer C., Zhang, Jianhua, Maitra, Anirban, Yee, Cassian

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Surveying Mechanisms of Immune Checkpoint Blockade from a VISTA von Wei, Spencer C

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Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway von Wei, Spencer C., Fattet, Laurent, Tsai, Jeff H., Guo, Yurong, Pai, Vincent H., Majeski, Hannah E., Chen, Albert C., Sah, Robert L., Taylor, Susan S., Engler, Adam J., Yang, Jing

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T cells specific for α-myosin drive immunotherapy-related myocarditis von Axelrod, Margaret L., Meijers, Wouter C., Screever, Elles M., Qin, Juan, Carroll, Mary Grace, Sun, Xiaopeng, Tannous, Elie, Zhang, Yueli, Sugiura, Ayaka, Taylor, Brandie C., Hanna, Ann, Zhang, Shaoyi, Amancherla, Kaushik, Tai, Warren, Wright, Jordan J., Wei, Spencer C., Opalenik, Susan R., Toren, Abigail L., Rathmell, Jeffrey C., Ferrell, P. Brent, Phillips, Elizabeth J., Mallal, Simon, Johnson, Douglas B., Allison, James P., Moslehi, Javid J., Balko, Justin M.

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The forces behind EMT and tumor metastasis von Wei, Spencer C, Fattet, Laurent, Yang, Jing

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Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States von Wei, Spencer C., Sharma, Roshan, Anang, Nana-Ama A.S., Levine, Jacob H., Zhao, Yang, Mancuso, James J., Setty, Manu, Sharma, Padmanee, Wang, Jing, Pe’er, Dana, Allison, James P.

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Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug–unresponsive hyperalgesia in male rats von Gregus, Ann M., Buczynski, Matthew W., Dumlao, Darren S., Norris, Paul C., Rai, Ganesha, Simeonov, Anton, Maloney, David J., Jadhav, Ajit, Xu, Qinghao, Wei, Spencer C., Fitzsimmons, Bethany L., Dennis, Edward A., Yaksh, Tony L.

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Systematic analysis of rat 12/15‐lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia von Gregus, Ann M., Dumlao, Darren S., Wei, Spencer C., Norris, Paul C., Catella, Laura C., Meyerstein, Flore G., Buczynski, Matthew W., Steinauer, Joanne J., Fitzsimmons, Bethany L., Yaksh, Tony L., Dennis, Edward A.

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Checkpoint Blockade + Chemotherapy: the Right Combination for AML? von Wei, Spencer C, Mancuso, James J, Daver, Naval, Allison, James P

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805 Clonal, activated CD8+ T cells recognizing cardiac alpha-myosin drive immune checkpoint inhibitor associated myocarditis in mice von Axelrod, Margaret, Meijers, Wouter, Tannous, Elie, Sun, Xiaopeng, Qin, Juan, Sugiura, Ayaka, Wescott, Elizabeth, Screever, Elles, Wei, Spencer, Opalenik, Susan, Zhang, Yueli, Johnson, Douglas, Allison, James, Moslehi, Javid, Balko, Justin

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A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitors-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention von Wei, Spencer C., Meijers, Wouter C., Axelrod, Margaret L., Anang, Nana-Ama A. S., Screever, Elles M., Wescott, Elizabeth C., Johnson, Douglas B., Whitley, Elizabeth, Lehmann, Lorenz, Courand, Pierre-Yves, Mancuso, James J., Himmel, Lauren E., Lebrun-Vignes, Benedicte, Wleklinski, Matthew J., Knollmann, Bjorn C., Srinivasan, Jayashree, Li, Yu, Atolagbe, Oluwatomisin T., Rao, Xiayu, Zhao, Yang, Wang, Jing, Ehrlich, Lauren I. R., Sharma, Padmanee, Salem, Joe-Elie, Balko, Justin M., Moslehi, Javid J., Allison, James P.

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Stress tolerance to stress escape in plants: role of the OXS2 zinc-finger transcription factor family von Blanvillain, Robert, Wei, Spencer, Wei, Pengcheng, Kim, Jong Heon, Ow, David W

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A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention von Wei, Spencer C, Meijers, Wouter C, Axelrod, Margaret L, Anang, Nana-Ama A S, Screever, Elles M, Wescott, Elizabeth C, Johnson, Douglas B, Whitley, Elizabeth, Lehmann, Lorenz, Courand, Pierre-Yves, Mancuso, James J, Himmel, Lauren E, Lebrun-Vignes, Benedicte, Wleklinski, Matthew J, Knollmann, Bjorn C, Srinivasan, Jayashree, Li, Yu, Atolagbe, Oluwatomisin T, Rao, Xiayu, Zhao, Yang, Wang, Jing, Ehrlich, Lauren I R, Sharma, Padmanee, Salem, Joe-Elie, Balko, Justin M, Moslehi, Javid J, Allison, James P

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Mechanical Signaling in Epithelial‐Mesenchymal Transition von Engler, Adam, Yang, Jing, Ondeck, Matthew, Wei, Spencer

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Combination of PD1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer von Ma, Ying, Li, Jun, Wang, Huamin, Chiu, Yulun, Kingsley, Charles V., Fry, David, Delaney, Samantha N., Wei, Spencer C., Zhang, Jianhua, Maitra, Anirban, Yee, Cassian

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Abstract 592: Distinct cellular mechanisms mediate anti-CTLA-4 and anti-PD-1 checkpoint blockade von Wei, Spencer C., Levine, Jacob H., Pe'er, Dana, Allison, James P.

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