Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands von Moraga, Ignacio, Wernig, Gerlinde, Wilmes, Stephan, Gryshkova, Vitalina, Richter, Christian P., Hong, Wan-Jen, Sinha, Rahul, Guo, Feng, Fabionar, Hyna, Wehrman, Tom S., Krutzik, Peter, Demharter, Samuel, Plo, Isabelle, Weissman, Irving L., Minary, Peter, Majeti, Ravindra, Constantinescu, Stefan N., Piehler, Jacob, Garcia, K. Christopher

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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling von Ho, Chia Chi M., Chhabra, Akanksha, Starkl, Philipp, Schnorr, Peter-John, Wilmes, Stephan, Moraga, Ignacio, Kwon, Hye-Sook, Gaudenzio, Nicolas, Sibilano, Riccardo, Wehrman, Tom S., Gakovic, Milica, Sockolosky, Jonathan T., Tiffany, Matthew R., Ring, Aaron M., Piehler, Jacob, Weissman, Irving L., Galli, Stephen J., Shizuru, Judith A., Garcia, K. Christopher

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor von Burford, Neil T., Clark, Mary J., Wehrman, Tom S., Gerritz, Samuel W., Banks, Martyn, O'Connell, Jonathan, Traynor, John R., Alt, Andrew

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Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors von Rajagopal, Sudarshan, Bassoni, Daniel L., Campbell, James J., Gerard, Norma P., Gerard, Craig, Wehrman, Tom S.

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Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers von Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher

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Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled Receptors von Southern, Craig, Cook, Jennifer M., Neetoo-Isseljee, Zaynab, Taylor, Debra L., Kettleborough, Catherine A., Merritt, Andy, Bassoni, Daniel L., Raab, William J., Quinn, Elizabeth, Wehrman, Tom S., Davenport, Anthony P., Brown, Andrew J., Green, Andrew, Wigglesworth, Mark J., Rees, Steve

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Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor von Burford, Neil T, Livingston, Kathryn E, Canals, Meritxell, Ryan, Molly R, Budenholzer, Lauren M. L, Han, Ying, Shang, Yi, Herbst, John J, O’Connell, Jonathan, Banks, Martyn, Zhang, Litao, Filizola, Marta, Bassoni, Daniel L, Wehrman, Tom S, Christopoulos, Arthur, Traynor, John R, Gerritz, Samuel W, Alt, Andrew

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novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization von Hammer, Mark M, Wehrman, Tom S, Blau, Helen M

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Restriction enzyme-generated siRNA (REGS) vectors and libraries von Blau, Helen M, Sen, George, Wehrman, Tom S, Myers, Jason W

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Protein-Protein Interactions Monitored in Mammalian Cells via Complementation of β-Lactamase Enzyme Fragments von Wehrman, Tom, Kleaveland, Benjamin, Her, Jeng-Horng, Balint, Robert F., Blau, Helen M.

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Enzymatic detection of protein translocation von Blau, Helen M, Wehrman, Tom S, Casipit, Clayton L, Gewertz, Nevin M

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universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals von von Degenfeld, Georges, Wehrman, Tom S, Hammer, Mark M, Blau, Helen M

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Measurements of β-Arrestin Recruitment to Activated Seven Transmembrane Receptors Using Enzyme Complementation von Bassoni, Daniel L., Raab, William J., Achacoso, Philip L., Loh, Chin Yee, Wehrman, Tom S.

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Pathway Phenotyping of B-Cell Receptor Activation and Inhibition: Translation to Novel Clinical Biomarkers von Wehrman, Tom S

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Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors von Wehrman, Tom, He, Xiaolin, Raab, Bill, Dukipatti, Abhiram, Blau, Helen, Garcia, K. Christopher

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Abstract 3036: Intracellular phospho-flow reveals novel insights to pathway modulation by tirabrutinib in combination with entospletinib and obinutuzumab von Yang, Xiaoyun, Wehrman, Tom, Laboriante, Justin, Li, Biao, Kutsch, Nadine, Pallasch, Christian, Eichhorst, Barbara, Jürgensmeier, Juliane M.

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Characterization of G-Protein Coupled Receptor Modulators Using Homogeneous cAMP Assays von Bassoni, Daniel L., Jafri, Qumber, Sastry, Sunitha, Mathrubutham, Mahesh, Wehrman, Tom S.

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mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage von Sen, George L., Wehrman, Tom S., Blau, Helen M.

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Imaging β-Galactosidase Activity In Vivo Using Sequential Reporter-Enzyme Luminescence von von Degenfeld, Georges, Wehrman, Tom S., Blau, Helen M.

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Identification of Selective Agonists and Positive Allosteric Modulators for µ- and δ-Opioid Receptors from a Single High-Throughput Screen von Burford, Neil T., Wehrman, Tom, Bassoni, Daniel, O’Connell, Jonathan, Banks, Martyn, Zhang, Litao, Alt, Andrew

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