Single-vector inducible lentiviral RNAi system for oncology target validation von Wiederschain, Dmitri, Susan, Wee, Chen, Lin, Loo, Alice, Yang, Guizhi, Huang, Alan, Chen, Yan, Caponigro, Giordano, Yao, Yung-mae, Lengauer, Christoph, Sellers, William R., Benson, John D.

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PTEN-deficient cancers depend on PIK3CB von Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers von Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells von Brachmann, Saskia M, Hofmann, Irmgard, Schnell, Christian, Fritsch, Christine, Wee, Susan, Lane, Heidi, Wang, Shaowen, Garcia-Echeverria, Carlos, Maira, Sauveur-Michel

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Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression von Lenhart, Ryan, Kirov, Stefan, Desilva, Heshani, Cao, Jian, Lei, Ming, Johnston, Kathy, Peterson, Russell, Schweizer, Liang, Purandare, Ashok, Ross-Macdonald, Petra, Fairchild, Craig, Wong, Tai, Wee, Susan

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Targeting epigenetic regulators for cancer therapy von Wee, Susan, Dhanak, Dash, Li, Haitao, Armstrong, Scott A., Copeland, Robert A., Sims, Robert, Baylin, Stephen B., Liu, Xiaole Shirley, Schweizer, Liang

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F-Box-Directed CRL Complex Assembly and Regulation by the CSN and CAND1 von Schmidt, Michael W., McQuary, Philip R., Wee, Susan, Hofmann, Kay, Wolf, Dieter A.

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BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases von Geyer, Rory, Wee, Susan, Anderson, Scott, Yates, John, Wolf, Dieter A.

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The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? von Wolf, Dieter A, Zhou, Chunshui, Wee, Susan

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CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability von Wolf, Dieter A, Wee, Susan, Geyer, Rory K, Toda, Takashi

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DGK zeta exerts greater control than DGK alpha over CD8(+) T cell activity and tumor inhibition von Gu, Junchen, Wang, Cindy, Cao, Carolyn, Huang, Jinwen, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin M., Evans, Douglas B., Benci, Joseph, Wichroski, Michael, Wee, Susan, Riese, Matthew J.

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PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes von Zhou, Chunshui, Arslan, Fatih, Wee, Susan, Krishnan, Srinivasan, Ivanov, Alexander R, Oliva, Anna, Leatherwood, Janet, Wolf, Dieter A

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Why is cancer drug discovery so difficult? von Lengauer, Christoph, Kamb, Alexander, Wee, Susan

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Abstract 1374: Identification of a transcription factor driving BET dependency in SCLC von Wee, Susan, Wong, Tai

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Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice von Hashimoto, Ayumi, Gao, Chan, Mastio, Jerome, Kossenkov, Andrew, Abrams, Scott I, Purandare, Ashok V, Desilva, Heshani, Wee, Susan, Hunt, John, Jure-Kunkel, Maria, Gabrilovich, Dmitry I

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Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ von Wee, Susan, Gu, Junchen, Wang, Cindy, Cao, Carolyn, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin, Tsai, Susan, Evans, Douglas, Riese, Matthew

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Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2 von Hummel, Joshua R., Xiao, Kai-Jiong, Yang, Jeffrey C., Epling, Leslie B., Mukai, Ken, Ye, Qinda, Xu, Meizhong, Qian, Dingquan, Huo, Lu, Weber, Michael, Roman, Valerie, Lo, Yvonne, Drake, Katherine, Stump, Kristine, Covington, Maryanne, Kapilashrami, Kanishk, Zhang, Guofeng, Ye, Min, Diamond, Sharon, Yeleswaram, Swamy, Macarron, Ricardo, Deller, Marc C., Wee, Susan, Kim, Sunkyu, Wang, Xiaozhao, Wu, Liangxing, Yao, Wenqing

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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design von Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y

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Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization von Chupak, Louis, Wichroski, Michael, Zheng, Xiaofan, Ding, Min, Martin, Scott, Allard, Christopher, Shi, Jianliang, Gentles, Robert, Meanwell, Nicholas A., Fang, Jie, Tenney, Daniel, Tokarski, John, Cao, Carolyn, Wee, Susan

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Characterization of INCB00928, a Potent and Selective ALK2 Inhibitor for the Treatment of Anemia von Chen, Yaoyu, Stubbs, Matthew C., Pusey, Michelle, Wen, Xiaoming, Collins, Robert J., Kapilashrami, Kanishk, Rupar, Mark, Thekkat, Pramod, Lin, Luping, Bowman, Kevin, Yang, Yan-ou, Diamond, Sharon, Yeleswaram, Swamy, Kim, Sunkyu, Koblish, Holly K., Chen, Yingnan, Wee, Susan

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