Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy von Toepfer, Christopher N., Garfinkel, Amanda C., Venturini, Gabriela, Wakimoto, Hiroko, Repetti, Giuliana, Alamo, Lorenzo, Sharma, Arun, Agarwal, Radhika, Ewoldt, Jourdan F., Cloonan, Paige, Letendre, Justin, Lun, Mingyue, Olivotto, Iacopo, Colan, Steve, Ashley, Euan, Jacoby, Daniel, Michels, Michelle, Redwood, Charles S., Watkins, Hugh C., Day, Sharlene M., Staples, James F., Padrón, Raúl, Chopra, Anant, Ho, Carolyn Y., Chen, Christopher S., Pereira, Alexandre C., Seidman, Jonathan G., Seidman, Christine E.

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Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield von Thomson, Kate L., Ormondroyd, Elizabeth, Harper, Andrew R., Dent, Tim, McGuire, Karen, Baksi, John, Blair, Edward, Brennan, Paul, Buchan, Rachel, Bueser, Teofila, Campbell, Carolyn, Carr-White, Gerald, Cook, Stuart, Daniels, Matthew, Deevi, Sri V.V., Goodship, Judith, Hayesmoore, Jesse B.G., Henderson, Alex, Lamb, Teresa, Prasad, Sanjay, Rayner-Matthews, Paula, Robert, Leema, Sneddon, Linda, Stark, Hannah, Walsh, Roddy, Ware, James S., Farrall, Martin, Watkins, Hugh C.

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Toward Replacing Late Gadolinium Enhancement With Artificial Intelligence Virtual Native Enhancement for Gadolinium-Free Cardiovascular Magnetic Resonance Tissue Characterization i... von Zhang, Qiang, Burrage, Matthew K., Lukaschuk, Elena, Shanmuganathan, Mayooran, Popescu, Iulia A., Nikolaidou, Chrysovalantou, Mills, Rebecca, Werys, Konrad, Hann, Evan, Barutcu, Ahmet, Polat, Suleyman D., Salerno, Michael, Jerosch-Herold, Michael, Kwong, Raymond Y., Watkins, Hugh C., Kramer, Christopher M., Neubauer, Stefan, Ferreira, Vanessa M., Piechnik, Stefan K.

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Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy: SEQUOIA-HCM Baseline Characteristics and Study Design von Coats, Caroline J, Maron, Martin S, Abraham, Theodore P, Olivotto, Iacopo, Lee, Matthew M Y, Arad, Michael, Cardim, Nuno, Ma, Chang-Sheng, Choudhury, Lubna, Düngen, Hans-Dirk, Garcia-Pavia, Pablo, Hagège, Albert A, Lewis, Gregory D, Michels, Michelle, Oreziak, Artur, Owens, Anjali T, Tfelt-Hansen, Jacob, Veselka, Josef, Watkins, Hugh C, Heitner, Stephen B, Jacoby, Daniel L, Kupfer, Stuart, Malik, Fady I, Meng, Lisa, Wohltman, Amy, Masri, Ahmad

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Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein von VICKERS, Mark A, GREEN, Fiona R, TERRY, Catherine, MAYOSI, Bongani M, JULIER, Cecile, LATHROP, Mark, RATCLIFFE, Peter J, WATKINS, Hugh C, KEAVNEY, Bernard

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Cardiac nitric oxide synthase 1 regulates basal and β-adrenergic contractility in murine ventricular myocytes von ASHLEY, Euan A, SEARS, Claire E, BRYANT, Simon M, WATKINS, Hugh C, CASADEI, Barbara

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Quantifying prion disease penetrance using large population control cohorts von Minikel, EV, Vallabh, SM, Lek, M, Estrada, K, Samocha, KE, Sathirapongsasuti, JF, McLean, CY, Tung, JY, Yu, LPC, Gambetti, P, Blevins, J, Zhang, SL, Cohen, Y, Chen, W, Yamada, M, Hamaguchi, T, Sanjo, N, Mizusawa, H, Nakamura, Y, Kitamoto, T, Collins, SJ, Boyd, A, Will, RG, Knight, R, Ponto, C, Zerr, I, Kraus, TFJ, Eigenbrod, S, Giese, A, Calero, M, de Pedro-Cuesta, J, Haik, S, Laplanche, JL, Bouaziz-Amar, E, Brandel, JP, Capellari, S, Parchi, P, Poleggi, A, Ladogana, A, O'Donnell-Luria, AH, Karczewski, KJ, Marshall, JL, Boehnke, M, Laakso, M, Mohlke, KL, Kahler, A, Chambert, K, McCarroll, S, Sullivan, PF, Hultman, CM, Purcell, SM, Sklar, P, van der Lee, SJ, Rozemuller, A, Jansen, C, Hofman, A, Kraaij, R, van Rooij, JGJ, Ikram, MA, Uitterlinden, AG, van Duijn, CM, Daly, MJ, MacArthur, DG

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Abstract 11789: Genetic Determinants of Interventricular Septal Anatomy and Risk of Congenital Heart Disease von Yu, Mengyao, Harper, Andrew, Aguirre, Matthew, Pittman, Maureen, Tcheandjieu, Catherine, Amgalan, Dulguun, Grace, Christopher, Goel, Anuj, Farrall, Martin, Xiao, Ke, Engreitz, Jesse, Pollard, Katherine, Watkins, Hugh C, Priest, James R

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Baseline Characteristics of Patients in SEQUOIA-HCM: A Phase 3 Trial of Aficamten in Obstructive Hypertrophic Cardiomyopathy von Maron, Martin S., Abraham, Theodore P., Coats, Caroline J., Olivotto, Iacopo, Lee, Matthew M.Y., Arad, Michael, Cardim, Nuno, Ma, Chang-Sheng, Choudhury, Lubna, Düngen, Hans-Dirk, Garcia-Pavia, Pablo, Hagege, Albert, Lewis, Gregory D., Michels, Michelle, Oreziak, Artur, Owens, Anjali T., Tfelt-Hansen, Jacob, Veselka, Josef, Watkins, Hugh C., Heitner, Stephen B., Jacoby, Daniel L., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Masri, Ahmad

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Towards Replacing Late Gadolinium Enhancement with Artificial Intelligence Virtual Native Enhancement for Gadolinium-Free Cardiovascular Magnetic Resonance Tissue Characterization... von Zhang, Qiang, Burrage, Matthew K., Lukaschuk, Elena, Shanmuganathan, Mayooran, Popescu, Iulia A., Nikolaidou, Chrysovalantou, Mills, Rebecca, Werys, Konrad, Hann, Evan, Barutcu, Ahmet, Polat, Suleyman D., Salerno, Michael, Jerosch-Herold, Michael, Kwong, Raymond Y., Watkins, Hugh C., Kramer, Christopher M., Neubauer, Stefan, Ferreira, Vanessa M., Piechnik, Stefan K.

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Abstract 16702: Myocardial Deformation Analysis in Hypertrophic Cardiomyopathy With Sarcomere Mutations: Insights From 2,221 Patients Within the NHLBI-HCM Registry von Heydari, Bobak, Satriano, Alessandro, White, James A, Merchant, Naeem, Mahmod, Masliza, Raman, Betty, Chan, Kenneth, Antiochos, Panagiotis, Jerosch-Herold, Michael, Ho, Carolyn Y, Weintraub, William S, Dolman, Sarahfaye, Kolm, Paul, Geller, Nancy, Kim, Dong-Yun, Desvigne-Nickens, Patrice, Dimarco, John P, Desai, Milind Y, Watkins, Hugh C, Neubauer, Stefan, Kramer, Christopher M, Kwong, Raymond Y

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Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy von Coats, Caroline J., Maron, Martin S., Abraham, Theodore P., Olivotto, Iacopo, Lee, Matthew M.Y., Arad, Michael, Cardim, Nuno, Ma, Chang-Sheng, Choudhury, Lubna, Düngen, Hans-Dirk, Garcia-Pavia, Pablo, Hagège, Albert A., Lewis, Gregory D., Michels, Michelle, Oreziak, Artur, Owens, Anjali T., Tfelt-Hansen, Jacob, Veselka, Josef, Watkins, Hugh C., Heitner, Stephen B., Jacoby, Daniel L., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Masri, Ahmad

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Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3 von MacRae, C A, Ghaisas, N, Kass, S, Donnelly, S, Basson, C T, Watkins, H C, Anan, R, Thierfelder, L H, McGarry, K, Rowland, E

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Hypertrophic cardiomyopathy von Ross, David, Watkins, Hugh C, McKenna, William J

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2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Socie... von Elliott, Perry M, Anastasakis, Aris, Borger, Michael A, Borggrefe, Martin, Cecchi, Franco, Charron, Philippe, Hagege, Albert Alain, Lafont, Antoine, Limongelli, Giuseppe, Mahrholdt, Heiko, McKenna, William J, Mogensen, Jens, Nihoyannopoulos, Petros, Nistri, Stefano, Pieper, Petronella G, Pieske, Burkert, Rapezzi, Claudio, Rutten, Frans H, Tillmanns, Christoph, Watkins, Hugh

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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants von Aragam, Krishna G., Jiang, Tao, Goel, Anuj, Kanoni, Stavroula, Wolford, Brooke N., Atri, Deepak S., Weeks, Elle M., Wang, Minxian, Hindy, George, Zhou, Wei, Grace, Christopher, Roselli, Carolina, Marston, Nicholas A., Kamanu, Frederick K., Surakka, Ida, Venegas, Loreto Muñoz, Sherliker, Paul, Koyama, Satoshi, Ishigaki, Kazuyoshi, Åsvold, Bjørn O., Brown, Michael R., Brumpton, Ben, de Vries, Paul S., Giannakopoulou, Olga, Giardoglou, Panagiota, Gudbjartsson, Daniel F., Güldener, Ulrich, Haider, Syed M. Ijlal, Helgadottir, Anna, Ibrahim, Maysson, Kastrati, Adnan, Kessler, Thorsten, Kyriakou, Theodosios, Konopka, Tomasz, Li, Ling, Ma, Lijiang, Meitinger, Thomas, Mucha, Sören, Munz, Matthias, Murgia, Federico, Nielsen, Jonas B., Nöthen, Markus M., Pang, Shichao, Reinberger, Tobias, Schnitzler, Gavin, Smedley, Damian, Thorleifsson, Gudmar, von Scheidt, Moritz, Ulirsch, Jacob C., Arnar, David O., Burtt, Noël P., Costanzo, Maria C., Flannick, Jason, Ito, Kaoru, Jang, Dong-Keun, Kamatani, Yoichiro, Khera, Amit V., Komuro, Issei, Kullo, Iftikhar J., Lotta, Luca A., Nelson, Christopher P., Roberts, Robert, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Webb, Thomas R., Baras, Aris, Björkegren, Johan L. M., Boerwinkle, Eric, Dedoussis, George, Holm, Hilma, Hveem, Kristian, Melander, Olle, Morrison, Alanna C., Orho-Melander, Marju, Rallidis, Loukianos S., Ruusalepp, Arno, Sabatine, Marc S., Stefansson, Kari, Zalloua, Pierre, Ellinor, Patrick T., Farrall, Martin, Danesh, John, Ruff, Christian T., Finucane, Hilary K., Hopewell, Jemma C., Clarke, Robert, Gupta, Rajat M., Erdmann, Jeanette, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Willer, Cristen J., Deloukas, Panos, Kathiresan, Sekar, Butterworth, Adam S.

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Genetic Basis of Atherosclerosis: Insights From Mice and Humans von Stylianou, Ioannis M, Bauer, Robert C, Reilly, Muredach P, Rader, Daniel J

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Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy von NAZARIAN, Saman, BLUEMKE, David A, WEISS, Robert G, BERGER, Ronald D, LIMA, Joao A. C, HALPERIN, Henry R, LARDO, Albert C, ZVIMAN, Menekhem M, WATKINS, Stanley P, DICKFELD, Timm L, MEININGER, Glenn R, ROGUIN, Ariel, CALKINS, Hugh, TOMASELLI, Gordon F

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Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease von Clarke, Robert, Peden, John F, Hopewell, Jemma C, Kyriakou, Theodosios, Goel, Anuj, Heath, Simon C, Parish, Sarah, Barlera, Simona, Franzosi, Maria Grazia, Rust, Stephan, Bennett, Derrick, Silveira, Angela, Malarstig, Anders, Green, Fiona R, Lathrop, Mark, Gigante, Bruna, Leander, Karin, de Faire, Ulf, Seedorf, Udo, Hamsten, Anders, Collins, Rory, Watkins, Hugh, Farrall, Martin

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A genomic mutational constraint map using variation in 76,156 human genomes von Chen, Siwei, Francioli, Laurent C., Goodrich, Julia K., Collins, Ryan L., Kanai, Masahiro, Wang, Qingbo, Alföldi, Jessica, Watts, Nicholas A., Vittal, Christopher, Gauthier, Laura D., Poterba, Timothy, Wilson, Michael W., Tarasova, Yekaterina, Phu, William, Grant, Riley, Yohannes, Mary T., Koenig, Zan, Farjoun, Yossi, Banks, Eric, Donnelly, Stacey, Gabriel, Stacey, Gupta, Namrata, Ferriera, Steven, Tolonen, Charlotte, Novod, Sam, Bergelson, Louis, Roazen, David, Ruano-Rubio, Valentin, Covarrubias, Miguel, Llanwarne, Christopher, Petrillo, Nikelle, Wade, Gordon, Jeandet, Thibault, Munshi, Ruchi, Tibbetts, Kathleen, O’Donnell-Luria, Anne, Solomonson, Matthew, Seed, Cotton, Martin, Alicia R., Talkowski, Michael E., Rehm, Heidi L., Daly, Mark J., Tiao, Grace, Neale, Benjamin M., MacArthur, Daniel G., Karczewski, Konrad J.

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