Drug‐induced liver injury: Advances in mechanistic understanding that will inform risk management von Mosedale, M, Watkins, PB

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Case Definition and Phenotype Standardization in Drug-Induced Liver Injury von Aithal, GP, Watkins, PB, Andrade, RJ, Larrey, D, Molokhia, M, Takikawa, H, Hunt, CM, Wilke, RA, Avigan, M, Kaplowitz, N, Bjornsson, E, Daly, AK

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Drug Safety Sciences and the Bottleneck in Drug Development von Watkins, PB

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Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans von Winnike, J H, Li, Z, Wright, F A, Macdonald, J M, O'Connell, T M, Watkins, P B

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The Application of Metabonomics to Predict Drug-Induced Liver Injury von O'Connell, T M, Watkins, P B

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The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers von Harrill, A H, Roach, J, Fier, I, Eaddy, J S, Kurtz, C L, Antoine, D J, Spencer, D M, Kishimoto, T K, Pisetsky, D S, Park, B K, Watkins, P B

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Comparative analysis of portal hepatic infiltrating leucocytes in acute drug‐induced liver injury, idiopathic autoimmune and viral hepatitis von Foureau, D. M., Walling, T. L., Maddukuri, V., Anderson, W., Culbreath, K., Kleiner, D. E., Ahrens, W. A., Jacobs, C., Watkins, P. B., Fontana, R. J., Chalasani, N., Talwalkar, J., Lee, W. M., Stolz, A., Serrano, J., Bonkovsky, H. L.

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MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics von Yang, Y., Nadanaciva, S., Will, Y., Woodhead, J. L., Howell, B. A., Watkins, P. B., Siler, S. Q.

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Interactions between seabirds and deep-water hake trawl gear: an assessment of impacts in South African waters von Watkins, B.P, Petersen, S.L, Ryan, P.G

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Serum proteomic profiling in patients with drug-induced liver injury von Bell, L. N., Vuppalanchi, R., Watkins, P. B., Bonkovsky, H. L., Serrano, J., Fontana, R. J., Wang, M., Rochon, J., Chalasani, N.

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Blood gene expression signatures predict exposure levels von Bushel, P.R, Heinloth, A.N, Li, J, Huang, L, Chou, J.W, Boorman, G.A, Malarkey, D.E, Houle, C.D, Ward, S.M, Wilson, R.E, Fannin, R.D, Russo, M.W, Watkins, P.B, Tennant, R.W, Paules, R.S

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Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials von Longo, DM, Generaux, GT, Howell, BA, Siler, SQ, Antoine, DJ, Button, D, Caggiano, A, Eisen, A, Iaci, J, Stanulis, R, Parry, T, Mosedale, M, Watkins, PB

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Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters von Yang, K, Battista, C, Woodhead, JL, Stahl, SH, Mettetal, JT, Watkins, PB, Siler, SQ, Howell, BA

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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym®, a Mechanistic Model of Drug‐Induced Liver Injury von Longo, DM, Yang, Y, Watkins, PB, Howell, BA, Siler, SQ

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Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen von Fannin, RD, Gerrish, K, Sieber, SO, Bushel, PR, Watkins, PB, Paules, RS

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Metabolomics in toxicology: preclinical and clinical applications von Robertson, Donald G, Watkins, Paul B, Reily, Michael D

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Hepatic Dysfunction Associated with Troglitazone von Watkins, Paul B, Whitcomb, Randall W

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Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity von Yang, K, Woodhead, J L, Watkins, P B, Howell, B A, Brouwer, K L R

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Managing the Risk of Drug-Induced Liver Injury von Watkins, P B

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Role of intestinal P-glycoprotein ( ) in interpatient variation in the oral bioavailability of cyclosporine von Lown, Kenneth S., Mayo, Robert R., Leichtman, Alan B., Hsiao, Hsiu‐ling, Turgeon, D. Kim, Schmiedlin‐Ren, Phyllissa, Brown, Morton B., Guo, Wensheng, Rossi, Stephen J., Benet, Leslie Z., Watkins, Paul B.

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