3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential von Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1 von Le Manach, Claire, Gonzàlez Cabrera, Diego, Douelle, Frederic, Nchinda, Aloysius T, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, White, Karen L, Ryan, Eileen, March, Corinne, Duffy, Sandra, Avery, Vicky M, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Street, Leslie J, Chibale, Kelly

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Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum von Avery, Vicky M, Bashyam, Sridevi, Burrows, Jeremy N, Duffy, Sandra, Papadatos, George, Puthukkuti, Shyni, Sambandan, Yuvaraj, Singh, Shivendra, Spangenberg, Thomas, Waterson, David, Willis, Paul

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum von Le Manach, Claire, Scheurer, Christian, Sax, Sibylle, Schleiferböck, Sarah, Cabrera, Diego Gonzalez, Younis, Yassir, Paquet, Tanya, Street, Leslie, Smith, Peter, Ding, Xavier C, Waterson, David, Witty, Michael J, Leroy, Didier, Chibale, Kelly, Wittlin, Sergio

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Screening a protein kinase inhibitor library against Plasmodium falciparum von Hallyburton, Irene, Grimaldi, Raffaella, Woodland, Andrew, Baragaña, Beatriz, Luksch, Torsten, Spinks, Daniel, James, Daniel, Leroy, Didier, Waterson, David, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H, Frearson, Julie A

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Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis von SHAHUL HAMEED, P, SOLAPURE, Suresh, GHOSH, Anirban, AWASTHY, Disha, SHANBHAG, Gajanan, SHEIKH, Gulebahar, MCMIKEN, Helen, PUTTUR, Jayashree, REDDY, Jitendar, WERNGREN, Jim, READ, Jon, KUMAR, Mahesh, MUKHERJEE, Kakoli, MANJUNATHA, R, CHINNAPATTU, Murugan, MADHAVAPEDDI, Prashanti, MANJREKAR, Praveena, BASU, Reetobrata, GAONKAR, Sheshagiri, SHARMA, Sreevalli, HOFFNER, Sven, HUMNABADKAR, Vaishali, SUBBULAKSHMI, Venkita, NANDI, Vrinda, PANDUGA, Vijender, WATERSON, David, SHANDIL, Radha, BALGANESH, Meenakshi, SAMBANDAMURTHY, Vasan K, ANAND KUMAR RAICHURKAR, DESHPANDE, Abhijeet

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Antimalarial drug discovery – the path towards eradication von BURROWS, JEREMY N, BURLOT, EMILIE, CAMPO, BRICE, CHERBUIN, STEPHANIE, JEANNERET, SARAH, LEROY, DIDIER, SPANGENBERG, THOMAS, WATERSON, DAVID, WELLS, TIMOTHY NC, WILLIS, PAUL

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Optimization of diastereomeric dihydropyridines as antimalarials von Van Horn, Kurt S., Zhao, Yingzhao, Parvatkar, Prakash T., Maier, Julie, Mutka, Tina, Lacrue, Alexis, Brockmeier, Fabian, Ebert, Daniel, Wu, Wesley, Casandra, Debora R., Namelikonda, Niranjan, Yacoub, Jeanine, Sigal, Martina, Knapp, Spencer, Floyd, David, Waterson, David, Burrows, Jeremy N., Duffy, James, DeRisi, Joseph L., Kyle, Dennis E., Guy, R. Kiplin, Manetsch, Roman

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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria von Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly

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Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy von Baragaña, Beatriz, Norcross, Neil R, Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C, Wyatt, Paul G, Delves, Michael J, Meister, Stephan, Duffy, Sandra, Avery, Vicky M, Winzeler, Elizabeth A, Sinden, Robert E, Wittlin, Sergio, Frearson, Julie A, Gray, David W, Fairlamb, Alan H, Waterson, David, Campbell, Simon F, Willis, Paul, Read, Kevin D, Gilbert, Ian H

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Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria von Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, El Mazouni, Farah, White, John, Shackleford, David M, Katneni, Kasiram, Chiu, Francis C. K, Barker, Helena, McLaren, Jenna, Crighton, Elly, Chen, Gong, Angulo-Barturen, Inigo, Jimenez-Diaz, Maria Belen, Ferrer, Santiago, Huertas-Valentin, Leticia, Martinez-Martinez, Maria Santos, Lafuente-Monasterio, Maria Jose, Chittimalla, Rajesh, Shahi, Shatrughan P, Wittlin, Sergio, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Tomchick, Diana, Rathod, Pradipsinh K, Palmer, Michael J, Charman, Susan A, Phillips, Margaret A

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Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity von Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K

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Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2 von Laleu, Benoît, Rubiano, Kelly, Yeo, Tomas, Hallyburton, Irene, Anderson, Mark, Crespo‐Fernandez, Benigno, Gamo, Francisco‐Javier, Antonova‐Koch, Yevgeniya, Orjuela‐Sanchez, Pamela, Wittlin, Sergio, Jana, Gouranga P., Maity, Bikash C., Chenu, Elodie, Duffy, James, Sjö, Peter, Waterson, David, Winzeler, Elizabeth, Guantai, Eric, Fidock, David A., Hansson, Thomas G.

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Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as Pf eEF2 von Laleu, Benoît, Rubiano, Kelly, Yeo, Tomas, Hallyburton, Irene, Anderson, Mark, Crespo‐Fernandez, Benigno, Gamo, Francisco‐Javier, Antonova‐Koch, Yevgeniya, Orjuela‐Sanchez, Pamela, Wittlin, Sergio, Jana, Gouranga P., Maity, Bikash C., Chenu, Elodie, Duffy, James, Sjö, Peter, Waterson, David, Winzeler, Elizabeth, Guantai, Eric, Fidock, David A., Hansson, Thomas G.

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Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle von Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly

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Novel Orally Active Antimalarial Thiazoles von González Cabrera, Diego, Douelle, Frederic, Feng, Tzu-Shean, Nchinda, Aloysius T, Younis, Yassir, White, Karen L, Wu, Quoc, Ryan, Eileen, Burrows, Jeremy N, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly

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Novel N‑Linked Aminopiperidine-Based Gyrase Inhibitors with Improved hERG and in Vivo Efficacy against Mycobacterium tuberculosis von Hameed P, Shahul, Patil, Vikas, Solapure, Suresh, Sharma, Umender, Madhavapeddi, Prashanti, Raichurkar, Anandkumar, Chinnapattu, Murugan, Manjrekar, Praveena, Shanbhag, Gajanan, Puttur, Jayashree, Shinde, Vikas, Menasinakai, Sreenivasaiah, Rudrapatana, Suresh, Achar, Vijayashree, Awasthy, Disha, Nandishaiah, Radha, Humnabadkar, Vaishali, Ghosh, Anirban, Narayan, Chandan, Ramya, V. K, Kaur, Parvinder, Sharma, Sreevalli, Werngren, Jim, Hoffner, Sven, Panduga, Vijender, Kumar, C. N. Naveen, Reddy, Jitendar, Kumar KN, Mahesh, Ganguly, Samit, Bharath, Sowmya, Bheemarao, Ugarkar, Mukherjee, Kakoli, Arora, Uma, Gaonkar, Sheshagiri, Coulson, Michelle, Waterson, David, Sambandamurthy, Vasan K, de Sousa, Sunita M

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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate von Hameed P., Shahul, Solapure, Suresh, Patil, Vikas, Henrich, Philipp P., Magistrado, Pamela A., Bharath, Sowmya, Murugan, Kannan, Viswanath, Pavithra, Puttur, Jayashree, Srivastava, Abhishek, Bellale, Eknath, Panduga, Vijender, Shanbag, Gajanan, Awasthy, Disha, Landge, Sudhir, Morayya, Sapna, Koushik, Krishna, Saralaya, Ramanatha, Raichurkar, Anandkumar, Rautela, Nikhil, Roy Choudhury, Nilanjana, Ambady, Anisha, Nandishaiah, Radha, Reddy, Jitendar, Prabhakar, K. R., Menasinakai, Sreenivasaiah, Rudrapatna, Suresh, Chatterji, Monalisa, Jiménez-Díaz, María Belén, Martínez, María Santos, Sanz, Laura María, Coburn-Flynn, Olivia, Fidock, David A., Lukens, Amanda K., Wirth, Dyann F., Bandodkar, Balachandra, Mukherjee, Kakoli, McLaughlin, Robert E., Waterson, David, Rosenbrier-Ribeiro, Lyn, Hickling, Kevin, Balasubramanian, V., Warner, Peter, Hosagrahara, Vinayak, Dudley, Adam, Iyer, Pravin S., Narayanan, Shridhar, Kavanagh, Stefan, Sambandamurthy, Vasan K.

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2 von Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, Lawrence, Nina, Schwager, Sylva, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly

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Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries von Younis, Yassir, Street, Leslie J, Waterson, David, Witty, Michael J, Chibale, Kelly

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