Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy von Bennett, Jason W, Yadava, Anjali, Tosh, Donna, Sattabongkot, Jetsumon, Komisar, Jack, Ware, Lisa A, McCarthy, William F, Cowden, Jessica J, Regules, Jason, Spring, Michele D, Paolino, Kristopher, Hartzell, Joshua D, Cummings, James F, Richie, Thomas L, Lumsden, Joanne, Kamau, Edwin, Murphy, Jittawadee, Lee, Cynthia, Parekh, Falgunee, Birkett, Ashley, Cohen, Joe, Ballou, W Ripley, Polhemus, Mark E, Vanloubbeeck, Yannick F, Vekemans, Johan, Ockenhouse, Christian F

Volltext

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A von Spring, Michele D, Cummings, James F, Ockenhouse, Christian F, Dutta, Sheetij, Reidler, Randall, Angov, Evelina, Bergmann-Leitner, Elke, Stewart, V Ann, Bittner, Stacey, Juompan, Laure, Kortepeter, Mark G, Nielsen, Robin, Krzych, Urszula, Tierney, Ev, Ware, Lisa A, Dowler, Megan, Hermsen, Cornelus C, Sauerwein, Robert W, de Vlas, Sake J, Ofori-Anyinam, Opokua, Lanar, David E, Williams, Jack L, Kester, Kent E, Tucker, Kathryn, Shi, Meng, Malkin, Elissa, Long, Carole, Diggs, Carter L, Soisson, Lorraine, Dubois, Marie-Claude, Ballou, W Ripley, Cohen, Joe, Heppner, Jr, D Gray

Volltext

Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to T... von STEWART, V. Ann, MCGRATH, Shannon M, DEMOITIE, Marie-Ange, JAN WEVERLING, Gerrit, BAYAT, Babak, CUSTERS, Jerome H. H. V, DUBOIS, Marie-Claude, COHEN, Joe, GOUDSMIT, Jaap, GRAY HEPPNER, D, DUBOIS, Patrice M, PAU, Maria G, METTENS, Pascal, SHOTT, Joseph, COBB, Michelle, BURGE, J. Robert, LARSON, David, WARE, Lisa A

Volltext

Novel Chimeric Plasmodium vivax Circumsporozoite Protein Induces Biologically Functional Antibodies That Recognize both VK210 and VK247 Sporozoites von Yadava, Anjali, Sattabongkot, Jetsumon, Washington, Michael A, Ware, Lisa A, Majam, Victoria, Zheng, Hong, Kumar, Sanjai, Ockenhouse, Christian F

Volltext

Process Development and Analysis of Liver-Stage Antigen 1, a Preerythrocyte-Stage Protein-Based Vaccine for Plasmodium falciparum von Hillier, Collette J, Ware, Lisa A, Barbosa, Arnoldo, Angov, Evelina, Lyon, Jeffrey A, Heppner, D. Gray, Lanar, David E

Volltext

Mode of Action of Invasion-Inhibitory Antibodies Directed against Apical Membrane Antigen 1 of Plasmodium falciparum von Dutta, Sheetij, Haynes, J. David, Barbosa, Arnoldo, Ware, Lisa A, Snavely, Jeffrey D, Moch, J. Kathleen, Thomas, Alan W, Lanar, David E

Volltext

Purification, Characterization, and Immunogenicity of the Refolded Ectodomain of the Plasmodium falciparum Apical Membrane Antigen 1 Expressed in Escherichia coli von DUTTA, Sheetij, LALITHA, P. V, HAYNES, J. David, LANAR, David E, WARE, Lisa A, BARBOSA, Arnoldo, MOCH, J. Kathleen, VASSELL, Meredith A, FILETA, Bader B, KITOV, Svetlana, KOLODNY, Nelly, HEPPNER, D. Gray

Volltext

Merozoite Surface Protein 1 of Plasmodium vivax Induces a Protective Response against Plasmodium cynomolgi Challenge in Rhesus Monkeys von Dutta, Sheetij, Kaushal, Deep C, Ware, Lisa A, Puri, Sunil K, Kaushal, Nuzhat A, Narula, Atul, Upadhyaya, D. S, Lanar, David E

Volltext

Murine Immune Responses to Liver-Stage Antigen 1 Protein FMP011, a Malaria Vaccine Candidate, Delivered with Adjuvant AS01B or AS02A von Brando, Clara, Ware, Lisa A, Freyberger, Helen, Kathcart, April, Barbosa, Arnoldo, Cayphas, Sylvie, Demoitie, Marie-Ange, Mettens, Pascal, Heppner, D. Gray, Lanar, David E

Volltext

Low-dose dengue virus 3 human challenge model: a phase 1 open-label study von Waickman, Adam T., Newell, Krista, Lu, Joseph Q., Fang, HengSheng, Waldran, Mitchell, Gebo, Chad, Currier, Jeffrey R., Friberg, Heather, Jarman, Richard G., Klick, Michelle D., Ware, Lisa A., Endy, Timothy P., Thomas, Stephen J.

Volltext

Purification, Characterization, and Immunogenicity of a Disulfide Cross-Linked Plasmodium vivax Vaccine Candidate Antigen, Merozoite Surface Protein 1, Expressed in Escherichia col... von DUTTA, Sheetij, WARE, Lisa A, BARBOSA, Arnoldo, OCKENHOUSE, Christian F, LANAR, David E

Volltext

Production of the Subdomains of the Plasmodium falciparum Apical Membrane Antigen 1 Ectodomain and Analysis of the Immune Response von LALITHA, P. V, WARE, Lisa A, BARBOSA, Arnoldo, DUTTA, Sheetij, MOCH, J. Kathleen, HAYNES, J. David, FILETA, Bader B, WHITE, Charles E, LANAR, David E

Volltext

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experim... von Cummings, James F, Spring, Michele D, Schwenk, Robert J, Ockenhouse, Christian F, Kester, Kent E, Polhemus, Mark E, Walsh, Douglas S, Yoon, In-Kyu, Prosperi, Christine, Juompan, Laure Y, Lanar, David E, Krzych, Urszula, Hall, B. Ted, Ware, Lisa A, Stewart, V. Ann, Williams, Jack, Dowler, Megan, Nielsen, Robin K, Hillier, Collette J, Giersing, Birgitte K, Dubovsky, Filip, Malkin, Elissa, Tucker, Kathryn, Dubois, Marie-Claude, Cohen, Joe D, Ballou, W. Ripley, Jr, D. Gray Heppner

Volltext

Process development for the production of an E. coli produced clinical grade recombinant malaria vaccine for Plasmodium vivax von Bell, Brian A, Wood, James F, Bansal, Reeta, Ragab, Hatem, Cargo, John, Washington, Michael A, Wood, Chloe L, Ware, Lisa A, Ockenhouse, Christian F, Yadava, Anjali

Volltext

Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A von Stewart, V. Ann, McGrath, Shannon M., Walsh, Douglas S., Davis, Stacey, Hess, Aaron S., Ware, Lisa A., Kester, Kent E., Cummings, James F., Burge, J. Robert, Voss, Gerald, Delchambre, Martine, Garçon, Nathalie, Tang, Douglas B., Cohen, Joe D., Heppner, D. Gray

Volltext

Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walte... von Polhemus, Mark E, Magill, Alan J, Cummings, James F, Kester, Kent E, Ockenhouse, Chris F, Lanar, David E, Dutta, Sheetij, Barbosa, Arnoldo, Soisson, Lorraine, Diggs, Carter L, Robinson, Sally A, Haynes, John D, Stewart, V. Ann, Ware, Lisa A, Brando, Clara, Krzych, Urszula, Bowden, Robert A, Cohen, Joe D, Dubois, Marie-Claude, Ofori-Anyinam, Opokua, De-Kock, Els, Ballou, W. Ripley, Heppner, D. Gray

Volltext

Comparison of the immune responses induced by soluble and particulate Plasmodium vivax circumsporozoite vaccine candidates formulated in AS01 in rhesus macaques von Vanloubbeeck, Yannick, Pichyangkul, Sathit, Bayat, Babak, Yongvanitchit, Kosol, Bennett, Jason W, Sattabongkot, Jetsumon, Schaecher, Kurt, Ockenhouse, Christian F, Cohen, Joe, Yadava, Anjali

Volltext

Expression, purification and characterization of a functional region of the Plasmodium vivax Duffy binding protein von Dutta, Sheetij, Daugherty, Jon R, Ware, Lisa A, Lanar, David E, Ockenhouse, Christian F

Volltext

Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research von Heppner, D. Gray, Kester, Kent E., Ockenhouse, Christian F., Tornieporth, Nadia, Ofori, Opokua, Lyon, Jeffrey A., Stewart, V. Ann, Dubois, Patrice, Lanar, David E., Krzych, Urszula, Moris, Philippe, Angov, Evelina, Cummings, James F., Leach, Amanda, Hall, B. Ted, Dutta, Sheetij, Schwenk, Robert, Hillier, Collette, Barbosa, Arnoldo, Ware, Lisa A., Nair, Lalitha, Darko, Christian A., Withers, Mark R., Ogutu, Bernhards, Polhemus, Mark E., Fukuda, Mark, Pichyangkul, Sathit, Gettyacamin, Montip, Diggs, Carter, Soisson, Lorraine, Milman, Jessica, Dubois, Marie-Claude, Garçon, Nathalie, Tucker, Kathryn, Wittes, Janet, Plowe, Christopher V., Thera, Mahamadou A., Duombo, Ogobara K., Pau, Maria G., Goudsmit, Jaap, Ballou, W. Ripley, Cohen, Joe

Volltext

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01.sub.B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy von Bennett, Jason W, Yadava, Anjali, Tosh, Donna, Sattabongkot, Jetsumon, Komisar, Jack, Ware, Lisa A, McCarthy, William F, Cowden, Jessica J, Regules, Jason, Spring, Michele D, Paolino, Kristopher, Hartzell, Joshua D, Cummings, James F, Richie, Thomas L, Lumsden, Joanne, Kamau, Edwin, Murphy, Jittawadee, Lee, Cynthia, Parekh, Falgunee, Birkett, Ashley, Cohen, Joe, Ballou, W. Ripley, Polhemus, Mark E, Vanloubbeeck, Yannick F, Vekemans, Johan, Ockenhouse, Christian F

Volltext