Therapeutic opportunities within the DNA damage response von Pearl, Laurence H., Schierz, Amanda C., Ward, Simon E., Al-Lazikani, Bissan, Pearl, Frances M. G.

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Beware of N -Benzoyloxybenzamides von Cubitt, Jonathan, Davies, Mari, Riseley, Ross, Evans, Gabrielle, Gardiner, Sian E, Kariuki, Benson M, Ward, Simon E, Lloyd-Evans, Emyr, Waller-Evans, Helen, Jones, D Heulyn

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Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan von Meisenberg, Cornelia, Gilbert, Duncan C, Chalmers, Anthony, Haley, Vikki, Gollins, Simon, Ward, Simon E, El-Khamisy, Sherif F

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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 von Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W, Oliver, Antony W

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Central Nervous System Targeted Protein Degraders von Thomas, Bedwyr ab Ion, Lewis, H. Lois, Jones, D. Heulyn, Ward, Simon E

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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein von Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte El, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica Jr, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances Mg, Oliver, Antony W

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d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity von Kirkwood, Nerissa K, O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J, Huckvale, Rosemary, van Netten, Sietse M, Ward, Simon E, Richardson, Guy P, Kros, Corné J

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Subtype Selective γ‑Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update von Maramai, Samuele, Benchekroun, Mohamed, Ward, Simon E, Atack, John R

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African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase von West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth, Ward, Simon E.

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Journal of Medicinal Chemistry Collection: Drug Discovery in the UK von Ward, Simon E., Demont, Emmanuel H.

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AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications von Ward, Simon E, Pennicott, Lewis E, Beswick, Paul

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Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity von Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, Goodyear, Richard J, Derudas, Marco, Cantillon, Daire M, Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N, Osgood, Richard T, Wilson, Charlotte Donald, Bull, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J, Richardson, Guy P

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Synthesis of Polyprenylated Acylphloroglucinols Using Bridgehead Lithiation:  The Total Synthesis of Racemic Clusianone and a Formal Synthesis of Racemic Garsubellin A von Ahmad, Nadia M, Rodeschini, Vincent, Simpkins, Nigel S, Ward, Simon E, Blake, Alexander J

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Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives von Derudas, Marco, O'Reilly, Molly, Kirkwood, Nerissa K, Kenyon, Emma J, Grimsey, Sybil, Kitcher, Siân R, Workman, Shawna, Bull, James C, Ward, Simon E, Kros, Corné J, Richardson, Guy P

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Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis von Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-san, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao-yiu, Sze-Lok Cheng, Alfred

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Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase von Koulouris, Chloe R., Gardiner, Sian E., Harris, Tessa K., Elvers, Karen T., Mark Roe, S., Gillespie, Jason A., Ward, Simon E., Grubisha, Olivera, Nicholls, Robert A., Atack, John R., Bax, Benjamin D.

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Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions von Henderson, Scott H., West, Ryan A., Ward, Simon E., Honey, Mark A.

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Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives von Zeng, Xuezhen, Ward, Simon E, Zhou, Jingying, Cheng, Alfred S L

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Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion von Cockerill, G. Stuart, Angell, Richard M, Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A, Good, James A. D, Harland, Rachel, Johnson, Sara M, Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S, Paradowski, Michael, Peeples, Mark E, Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E, Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth

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How Do Gepotidacin and Zoliflodacin Stabilize DNA-Cleavage Complexes with Bacterial Type IIA Topoisomerases? 2. A Single Moving Metal Mechanism von Nicholls, Robert A., Morgan, Harry, Warren, Anna J., Ward, Simon E., Long, Fei, Murshudov, Garib N., Sutormin, Dmitry, Bax, Benjamin D.

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