Structure-based design of targeted covalent inhibitors von Lonsdale, Richard, Ward, Richard A

Volltext

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer von Cross, Darren A E, Ashton, Susan E, Ghiorghiu, Serban, Eberlein, Cath, Nebhan, Caroline A, Spitzler, Paula J, Orme, Jonathon P, Finlay, M Raymond V, Ward, Richard A, Mellor, Martine J, Hughes, Gareth, Rahi, Amar, Jacobs, Vivien N, Red Brewer, Monica, Ichihara, Eiki, Sun, Jing, Jin, Hailing, Ballard, Peter, Al-Kadhimi, Katherine, Rowlinson, Rachel, Klinowska, Teresa, Richmond, Graham H P, Cantarini, Mireille, Kim, Dong-Wan, Ranson, Malcolm R, Pao, William

Volltext

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions von Floc'h, Nicolas, Martin, Matthew J, Riess, Jonathan W, Orme, Jonathan P, Staniszewska, Anna D, Ménard, Ludovic, Cuomo, Maria Emanuela, O'Neill, Daniel J, Ward, Richard A, Finlay, M Raymond V, McKerrecher, Darren, Cheng, Mingshan, Vang, Daniel P, Burich, Rebekah A, Keck, James G, Gandara, David R, Mack, Philip C, Cross, Darren A E

Volltext

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR) von Ward, Richard A, Anderton, Mark J, Ashton, Susan, Bethel, Paul A, Box, Matthew, Butterworth, Sam, Colclough, Nicola, Chorley, Christopher G, Chuaqui, Claudio, Cross, Darren A. E, Dakin, Les A, Debreczeni, Judit É, Eberlein, Cath, Finlay, M. Raymond V, Hill, George B, Grist, Matthew, Klinowska, Teresa C. M, Lane, Clare, Martin, Scott, Orme, Jonathon P, Smith, Peter, Wang, Fengjiang, Waring, Michael J

Volltext

Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations von Avizienyte, Egle, Ward, Richard A, Garner, Andrew P

Volltext

Structural basis of the effect of activating mutations on the EGF receptor von Galdadas, Ioannis, Carlino, Luca, Ward, Richard A, Hughes, Samantha J, Haider, Shozeb, Gervasio, Francesco Luigi

Volltext

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily von Wrigley, Jonathan D, Gavory, Gerald, Simpson, Iain, Preston, Marian, Plant, Helen, Bradley, Jenna, Goeppert, Anne U, Rozycka, Ewelina, Davies, Gareth, Walsh, Jarrod, Valentine, Andrea, McClelland, Keeva, Odrzywol, Krzysztofa Ewa, Renshaw, Jonathan, Boros, Joanna, Tart, Jonathan, Leach, Lindsey, Nowak, Thorsten, Ward, Richard A, Harrison, Timothy, Andrews, David M

Volltext

Challenges and Opportunities in Cancer Drug Resistance von Ward, Richard A, Fawell, Stephen, Floc’h, Nicolas, Flemington, Vikki, McKerrecher, Darren, Smith, Paul D

Volltext

Re-Examining Neutrophil Participation in GN von Caster, Dawn J, Powell, David W, Miralda, Irina, Ward, Richard A, McLeish, Kenneth R

Volltext

Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst von Uriarte, Silvia M, Rane, Madhavi J, Luerman, Gregory C, Barati, Michelle T, Ward, Richard A, Nauseef, William M, McLeish, Kenneth R

Volltext

Proteomic Analysis of Human Neutrophil Granules von Lominadze, George, Powell, David W, Luerman, Greg C, Link, Andrew J, Ward, Richard A, McLeish, Kenneth R

Volltext

Extracorporeal Removal of Uremic Toxins: Can We Still Do Better? von Eloot, Sunny, PhD, Ledebo, Ingrid, PhD, Ward, Richard A., PhD

Volltext

Basic prerequisites for on‐line, high‐volume hemodiafiltration von Ward, Richard A.

Volltext

Hemodiafiltration to Address Unmet Medical Needs ESKD Patients von Canaud, Bernard, Vienken, Jörg, Ash, Stephen, Ward, Richard A

Volltext

Membrane innovation: closer to native kidneys von Storr, Markus, Ward, Richard A

Volltext

Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies von Zhai, Xiang, Ward, Richard A, Doig, Peter, Argyrou, Argyrides

Volltext

Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils von Creed, T. Michael, Tandon, Shweta, Ward, Richard A., McLeish, Kenneth R.

Volltext

Technical note: proteomic approaches to fundamental questions about neutrophil biology von McLeish, Kenneth R., Merchant, Michael L., Klein, Jon B., Ward, Richard A.

Volltext

Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats von Uriarte, Silvia M, Rane, Madhavi J, Merchant, Michael L, Jin, Shunying, Lentsch, Alex B, Ward, Richard A, McLeish, Kenneth R

Volltext

The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets von Jog, Neelakshi R, Rane, Madhavi J, Lominadze, George, Luerman, Gregory C, Ward, Richard A, McLeish, Kenneth R

Volltext